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Protein

Persephin

Gene

Pspn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.

GO - Molecular functioni

  • growth factor activity Source: UniProtKB-KW
  • signaling receptor binding Source: MGI

GO - Biological processi

  • branching involved in ureteric bud morphogenesis Source: MGI

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Persephin
Short name:
PSP
Gene namesi
Name:Pspn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1201684 Pspn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003401522 – 156PersephinAdd BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 124By similarity
Disulfide bondi93 ↔ 152By similarity
Disulfide bondi97 ↔ 154By similarity
Disulfide bondi123InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO70300
PRIDEiO70300

PTM databases

PhosphoSitePlusiO70300

Expressioni

Gene expression databases

CleanExiMM_PSPN

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002740

Structurei

3D structure databases

ProteinModelPortaliO70300
SMRiO70300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J061 Eukaryota
ENOG4111Y7H LUCA
HOGENOMiHOG000220877
HOVERGENiHBG008316
InParanoidiO70300
PhylomeDBiO70300

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGRLRILC LLLLSLHPSL GWVLDLQEAS VADKLSFGKM AETRGTWTPH
60 70 80 90 100
QGNNHVRLPR ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE
110 120 130 140 150
ARTQHSLVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA

ACGCGG
Length:156
Mass (Da):17,031
Last modified:August 1, 1998 - v1
Checksum:i7DC6DD98132E041B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1L3Q1A1L3Q1_MOUSE
Persephin
Pspn mCG_5585
156Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040960 mRNA Translation: AAC40057.1
CCDSiCCDS28922.1
UniGeneiMm.86487

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040960 mRNA Translation: AAC40057.1
CCDSiCCDS28922.1
UniGeneiMm.86487

3D structure databases

ProteinModelPortaliO70300
SMRiO70300
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002740

PTM databases

PhosphoSitePlusiO70300

Proteomic databases

PaxDbiO70300
PRIDEiO70300

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1201684 Pspn

Phylogenomic databases

eggNOGiENOG410J061 Eukaryota
ENOG4111Y7H LUCA
HOGENOMiHOG000220877
HOVERGENiHBG008316
InParanoidiO70300
PhylomeDBiO70300

Miscellaneous databases

PROiPR:O70300
SOURCEiSearch...

Gene expression databases

CleanExiMM_PSPN

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSPN_MOUSE
AccessioniPrimary (citable) accession number: O70300
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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