Wnt2b

Functionⁱ

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Plays a redundant role in embryonic lung development (PubMed:19686689).Curated1 Publication

GO - Molecular functionⁱ

frizzled binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: MGI
Traceable author statementⁱ
- 9889131

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ morphogenesis
Source: MGI
Traceable author statementⁱ
- 9889131
canonical Wnt signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 19686689
cell-cell signaling
Source: MGI
Traceable author statementⁱ
- 9889131
cell fate commitment
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to starvation
Source: MGI
Inferred from expression patternⁱ
- 23260145
chondrocyte differentiation Source: Ensembl
forebrain regionalization
Source: UniProtKB
Inferred from expression patternⁱ
- 15164427
hematopoietic stem cell proliferation Source: MGI
lung induction
Source: MGI
Inferred from genetic interactionⁱ
- 19686689
male gonad development Source: Ensembl
mesenchymal-epithelial cell signaling
Source: MGI
Inferred from direct assayⁱ
- 11507767
neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of branching involved in ureteric bud morphogenesis
Source: MGI
Inferred from direct assayⁱ
- 11507767
signal transduction
Source: MGI
Traceable author statementⁱ
- 9889131
Wnt signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3238698 WNT ligand biogenesis and trafficking

Reactomeⁱ

R-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Wnt-2b Alternative name(s): Protein Wnt-131 Publication
Gene namesⁱ	Name:Wnt2b Synonyms:Wnt131 Publication
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1261834 Wnt2b

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Disruption phenotypeⁱ

No visible phenotype at birth (PubMed:19686689). Combined disruption of Wnt2 and Wnt2b leads to lung agenesis (PubMed:19686689).1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000041414	? – 389	Protein Wnt-2b
Signal peptideⁱ	1 – ?	Sequence analysis

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	105 ↔ 116	By similarity
Glycosylationⁱ	115	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	156 ↔ 164	By similarity
Disulfide bondⁱ	166 ↔ 186	By similarity
Disulfide bondⁱ	235 ↔ 249	By similarity
Disulfide bondⁱ	237 ↔ 244	By similarity
Lipidationⁱ	241	O-palmitoleoyl serine; by PORCNBy similarity	1
Glycosylationⁱ	281	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	323 ↔ 338	By similarity
Disulfide bondⁱ	353 ↔ 368	By similarity
Disulfide bondⁱ	355 ↔ 365	By similarity
Disulfide bondⁱ	360 ↔ 361	By similarity

Post-translational modificationⁱ

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O70283
PaxDbⁱ	O70283
PRIDEⁱ	O70283

PTM databases

iPTMnetⁱ	O70283
PhosphoSitePlusⁱ	O70283

Expressionⁱ

Developmental stageⁱ

Detected at the dorsal midline at the level of the diencephalon and mesencephalon at 9.5 dpc. Detected at the level of the optic and otic vesicles at 9.5 dpc (PubMed:9545553). Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut at 9.5 dpc (PubMed:19686689). Detected in the mesothelium encasing the lung, and at lower levels in the distal mesenchyme from E12.5 to E14.5 dpc (PubMed:19686689).2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000027840 Expressed in 115 organ(s), highest expression level in embryo
CleanExⁱ	MM_WNT2B
Genevisibleⁱ	O70283 MM

Interactionⁱ

Subunit structureⁱ

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD4 and FZD5 (By similarity).By similarity

GO - Molecular functionⁱ

frizzled binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: MGI
Traceable author statementⁱ
- 9889131

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204573, 1 interactor
STRINGⁱ	10090.ENSMUSP00000029429

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O70283
SMRⁱ	O70283
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Wnt family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118943
HOGENOMⁱ	HOG000039529
HOVERGENⁱ	HBG001595
InParanoidⁱ	O70283
KEGG Orthology (KO) More...KOⁱ	K00182
OMAⁱ	DYCVMDK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OFF
TreeFamⁱ	TF105310

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR009140 Wnt2 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01842 WNT2PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O70283-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLKLQGEDEA AQLAPRRARV PVPRPTAPDV SPSSARLGLA CLLLLLLLTL 
        60         70         80         90        100
PARVDTSWWY IGALGARVIC DNIPGLVSRQ RQLCQRYPDI MRSVGEGARE 
       110        120        130        140        150
WIRECQHQFR HHRWNCTTLD RDHTVFGRAM LRSSREAAFV YAISSAGVVH 
       160        170        180        190        200
AITRACSQGE LSVCSCDPYT RGRHHDQRGD FDWGGCSDNI HYGVRFAKAF 
       210        220        230        240        250
VDAKEKRLKD ARALMNLHNN RCGRTAVRRF LKLECKCHGV SGSCTLRTCW 
       260        270        280        290        300
RALSDFRRTG DYLRRRYDGA VQVTATQDGA NFTAARQGYR HATRTDLVYF 
       310        320        330        340        350
DNSPDYCVLD KAAGSLGTAG RVCSKTSKGT DGCEIMCCGR GYDTTRVTRV 
       360        370        380 
TQCECKFHWC CAVRCKECRN TVDVHTCKAP KKAEWLDQT

Length:389

Mass (Da):43,753

Last modified:July 27, 2011 - v3

Checksum:ⁱ64F956BB9A00CEEB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	313	A → S in AAC25397 (PubMed:9545553).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF070988 mRNA Translation: AAC25397.1 AK035653 mRNA Translation: BAC29139.1 CH466608 Genomic DNA Translation: EDL07557.1 BC119276 mRNA Translation: AAI19277.1 BC119278 mRNA Translation: AAI19279.1 AF038384 mRNA Translation: AAC40123.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17706.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033546.2, NM_009520.3
UniGeneⁱ	Mm.10740

Genome annotation databases

Ensemblⁱ	ENSMUST00000029429; ENSMUSP00000029429; ENSMUSG00000027840
GeneIDⁱ	22414
KEGGⁱ	mmu:22414
UCSC genome browser More...UCSCⁱ	uc008qut.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O70283	Protein Wnt-2b		HUMAN		391	UniRef90_O70283
Protein Wnt		ERIEU		398
Protein Wnt		MONDO		398
Protein Wnt		DELLE		397
Protein Wnt		RABIT		397
+108

Protein	Similar proteins		Species	Score	Length	Source
O70283	Protein Wnt-2		HUMAN		360	UniRef50_P09544
Protein Wnt-2		AOTNA		360
Protein Wnt-2		CALJA		360
Protein Wnt-2		ATEGE		360
Protein Wnt-2		PLEMO		360
+543

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF070988 mRNA Translation: AAC25397.1 AK035653 mRNA Translation: BAC29139.1 CH466608 Genomic DNA Translation: EDL07557.1 BC119276 mRNA Translation: AAI19277.1 BC119278 mRNA Translation: AAI19279.1 AF038384 mRNA Translation: AAC40123.1
CCDSⁱ	CCDS17706.1
RefSeqⁱ	NP_033546.2, NM_009520.3
UniGeneⁱ	Mm.10740

3D structure databases

ProteinModelPortalⁱ	O70283
SMRⁱ	O70283
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204573, 1 interactor
STRINGⁱ	10090.ENSMUSP00000029429

PTM databases

iPTMnetⁱ	O70283
PhosphoSitePlusⁱ	O70283

Proteomic databases

MaxQBⁱ	O70283
PaxDbⁱ	O70283
PRIDEⁱ	O70283

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000029429; ENSMUSP00000029429; ENSMUSG00000027840
GeneIDⁱ	22414
KEGGⁱ	mmu:22414
UCSCⁱ	uc008qut.1 mouse

Organism-specific databases

CTDⁱ	7482
MGIⁱ	MGI:1261834 Wnt2b

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
GeneTreeⁱ	ENSGT00760000118943
HOGENOMⁱ	HOG000039529
HOVERGENⁱ	HBG001595
InParanoidⁱ	O70283
KOⁱ	K00182
OMAⁱ	DYCVMDK
OrthoDBⁱ	EOG091G0OFF
TreeFamⁱ	TF105310

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3238698 WNT ligand biogenesis and trafficking

Reactomeⁱ

R-MMU-3238698 WNT ligand biogenesis and trafficking

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O70283
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027840 Expressed in 115 organ(s), highest expression level in embryo
CleanExⁱ	MM_WNT2B
Genevisibleⁱ	O70283 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR009140 Wnt2 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01842 WNT2PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WNT2B_MOUSE
Accessionⁱ	O70283Primary (citable) accession number: O70283 Secondary accession number(s): O88530, Q544L3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O70283 (WNT2B_MOUSE)

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Protein Wnt-2b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ