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Protein

Protein Wnt-2b

Gene

Wnt2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Plays a redundant role in embryonic lung development (PubMed:19686689).Curated1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell-cell signaling Source: MGI
  • cell fate commitment Source: GO_Central
  • cellular response to starvation Source: MGI
  • chondrocyte differentiation Source: Ensembl
  • forebrain regionalization Source: UniProtKB
  • hematopoietic stem cell proliferation Source: MGI
  • lung induction Source: MGI
  • male gonad development Source: Ensembl
  • mesenchymal-epithelial cell signaling Source: MGI
  • neuron differentiation Source: GO_Central
  • positive regulation of branching involved in ureteric bud morphogenesis Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • signal transduction Source: MGI
  • Wnt signaling pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2b
Alternative name(s):
Protein Wnt-131 Publication
Gene namesi
Name:Wnt2b
Synonyms:Wnt131 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1261834 Wnt2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

No visible phenotype at birth (PubMed:19686689). Combined disruption of Wnt2 and Wnt2b leads to lung agenesis (PubMed:19686689).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000041414? – 389Protein Wnt-2b
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 116By similarity
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 164By similarity
Disulfide bondi166 ↔ 186By similarity
Disulfide bondi235 ↔ 249By similarity
Disulfide bondi237 ↔ 244By similarity
Lipidationi241O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi323 ↔ 338By similarity
Disulfide bondi353 ↔ 368By similarity
Disulfide bondi355 ↔ 365By similarity
Disulfide bondi360 ↔ 361By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiO70283
PaxDbiO70283
PRIDEiO70283

PTM databases

iPTMnetiO70283
PhosphoSitePlusiO70283

Expressioni

Developmental stagei

Detected at the dorsal midline at the level of the diencephalon and mesencephalon at 9.5 dpc. Detected at the level of the optic and otic vesicles at 9.5 dpc (PubMed:9545553). Detected in the lateral plate mesoderm surrounding the ventral aspect of the anterior foregut at 9.5 dpc (PubMed:19686689). Detected in the mesothelium encasing the lung, and at lower levels in the distal mesenchyme from E12.5 to E14.5 dpc (PubMed:19686689).2 Publications

Gene expression databases

BgeeiENSMUSG00000027840
CleanExiMM_WNT2B
GenevisibleiO70283 MM

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD4 and FZD5 (By similarity).By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: MGI

Protein-protein interaction databases

BioGridi204573, 1 interactor
STRINGi10090.ENSMUSP00000029429

Structurei

3D structure databases

ProteinModelPortaliO70283
SMRiO70283
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO70283
KOiK00182
OMAiDYCVMDK
OrthoDBiEOG091G0OFF
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009140 Wnt2
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01842 WNT2PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLQGEDEA AQLAPRRARV PVPRPTAPDV SPSSARLGLA CLLLLLLLTL
60 70 80 90 100
PARVDTSWWY IGALGARVIC DNIPGLVSRQ RQLCQRYPDI MRSVGEGARE
110 120 130 140 150
WIRECQHQFR HHRWNCTTLD RDHTVFGRAM LRSSREAAFV YAISSAGVVH
160 170 180 190 200
AITRACSQGE LSVCSCDPYT RGRHHDQRGD FDWGGCSDNI HYGVRFAKAF
210 220 230 240 250
VDAKEKRLKD ARALMNLHNN RCGRTAVRRF LKLECKCHGV SGSCTLRTCW
260 270 280 290 300
RALSDFRRTG DYLRRRYDGA VQVTATQDGA NFTAARQGYR HATRTDLVYF
310 320 330 340 350
DNSPDYCVLD KAAGSLGTAG RVCSKTSKGT DGCEIMCCGR GYDTTRVTRV
360 370 380
TQCECKFHWC CAVRCKECRN TVDVHTCKAP KKAEWLDQT
Length:389
Mass (Da):43,753
Last modified:July 27, 2011 - v3
Checksum:i64F956BB9A00CEEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313A → S in AAC25397 (PubMed:9545553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070988 mRNA Translation: AAC25397.1
AK035653 mRNA Translation: BAC29139.1
CH466608 Genomic DNA Translation: EDL07557.1
BC119276 mRNA Translation: AAI19277.1
BC119278 mRNA Translation: AAI19279.1
AF038384 mRNA Translation: AAC40123.1
CCDSiCCDS17706.1
RefSeqiNP_033546.2, NM_009520.3
UniGeneiMm.10740

Genome annotation databases

EnsembliENSMUST00000029429; ENSMUSP00000029429; ENSMUSG00000027840
GeneIDi22414
KEGGimmu:22414
UCSCiuc008qut.1 mouse

Similar proteinsi

Entry informationi

Entry nameiWNT2B_MOUSE
AccessioniPrimary (citable) accession number: O70283
Secondary accession number(s): O88530, Q544L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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