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Protein

Splicing factor ESS-2 homolog

Gene

Ess2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in pre-mRNA splicing.By similarity

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • nervous system development Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor ESS-2 homolog
Alternative name(s):
ES2 protein
Expressed sequence 2 embryonic lethal
Gene namesi
Name:Ess2
Synonyms:Dgcr14, Dgsi, Es2, Es2el
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107854 Ess2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798771 – 479Splicing factor ESS-2 homologAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphothreonineBy similarity1
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei295PhosphoserineBy similarity1
Modified residuei389PhosphothreonineBy similarity1
Modified residuei394PhosphoserineCombined sources1
Modified residuei398PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO70279
MaxQBiO70279
PaxDbiO70279
PeptideAtlasiO70279
PRIDEiO70279

PTM databases

iPTMnetiO70279
PhosphoSitePlusiO70279

Expressioni

Tissue specificityi

In the adult, widely expressed with highest expression in the testis and brain. Also widely expressed in the embryo with highest levels in the anterior pons.

Developmental stagei

Highly expressed during embryogenesis from E7 onwards.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003621

Family & Domainsi

Sequence similaritiesi

Belongs to the ESS2 family.Curated

Phylogenomic databases

eggNOGiKOG2627 Eukaryota
ENOG410YVA8 LUCA
GeneTreeiENSGT00390000009387
HOVERGENiHBG051342
InParanoidiO70279
KOiK13118

Family and domain databases

InterProiView protein in InterPro
IPR019148 Nuclear_protein_DGCR14_ESS-2
PANTHERiPTHR12940 PTHR12940, 1 hit
PfamiView protein in Pfam
PF09751 Es2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTPGTSAGA LFLSSASAPS RKRAAGEAGE AGVARSRQRV LDEEEYIEGL
60 70 80 90 100
QTVIQRDFFP DVEKLQAQKE YLEAEENGDL ERMRQIAIKF GSALGKISRE
110 120 130 140 150
PPPPYVTPAT FETPEVHPGS AVLGNKPRPQ GRDLDDGEAG EEEEKEPLPS
160 170 180 190 200
LDVFLSQYTS EDNASFQEIM EVAKEKSHAR HAWLYQAEEE FEKRQKDNLE
210 220 230 240 250
LPSAEHQAIE SSQAGVETWK YKAKNSLMYY PEGVPDEEQL FKKPRQIVHK
260 270 280 290 300
NTRFLRDPFS QALSRSQLQQ AAALNAQHKQ GKVGPDGKEL IPQESPRVGG
310 320 330 340 350
FGFVATPSPA PGVNESPLMT WGEVENTPLR VEGSESPYVD RTPGPTFKIL
360 370 380 390 400
EPGRRERLGL KMANEAAAKN RAKKQEALRR VTENLASLTP KGLSPAMSPA
410 420 430 440 450
LQRLVSRTAS KYTDRALRAS YTPSPARSSH LKTPAGGPQT PTSTPAPGSA
460 470
TRTPLTQDPA SITDNLLQLP ARRKASDFF
Length:479
Mass (Da):52,604
Last modified:January 17, 2003 - v2
Checksum:iA7BC852063D146A1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UFM6Q3UFM6_MOUSE
Expressed sequence 2 embryonic leth...
Ess2 Dgcr14, Es2el, mCG_131831
480Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84R → P in AAC40077 (PubMed:9499415).Curated1
Sequence conflicti136D → DA in AAC40077 (PubMed:9499415).Curated1
Sequence conflicti416 – 417AL → PV in AAC40077 (PubMed:9499415).Curated2
Sequence conflicti449S → F in BAC40400 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004412 Genomic DNA No translation available.
AF037256 mRNA Translation: AAC40077.1
AK088520 mRNA Translation: BAC40400.1
BC013711 mRNA Translation: AAH13711.1
RefSeqiNP_001075102.1, NM_001081633.1
UniGeneiMm.256480

Genome annotation databases

EnsembliENSMUST00000232423; ENSMUSP00000156085; ENSMUSG00000003527
GeneIDi27886
KEGGimmu:27886
UCSCiuc007ymn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004412 Genomic DNA No translation available.
AF037256 mRNA Translation: AAC40077.1
AK088520 mRNA Translation: BAC40400.1
BC013711 mRNA Translation: AAH13711.1
RefSeqiNP_001075102.1, NM_001081633.1
UniGeneiMm.256480

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003621

PTM databases

iPTMnetiO70279
PhosphoSitePlusiO70279

Proteomic databases

EPDiO70279
MaxQBiO70279
PaxDbiO70279
PeptideAtlasiO70279
PRIDEiO70279

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000232423; ENSMUSP00000156085; ENSMUSG00000003527
GeneIDi27886
KEGGimmu:27886
UCSCiuc007ymn.1 mouse

Organism-specific databases

CTDi8220
MGIiMGI:107854 Ess2

Phylogenomic databases

eggNOGiKOG2627 Eukaryota
ENOG410YVA8 LUCA
GeneTreeiENSGT00390000009387
HOVERGENiHBG051342
InParanoidiO70279
KOiK13118

Miscellaneous databases

ChiTaRSiDgcr14 mouse
PROiPR:O70279
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR019148 Nuclear_protein_DGCR14_ESS-2
PANTHERiPTHR12940 PTHR12940, 1 hit
PfamiView protein in Pfam
PF09751 Es2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESS2_MOUSE
AccessioniPrimary (citable) accession number: O70279
Secondary accession number(s): Q91YX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 17, 2003
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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