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Protein

Protein tyrosine phosphatase type IVA 2

Gene

Ptp4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Activity regulationi

Inhibited by sodium orthovanadate and pentamidine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Proton donorBy similarity1
Active sitei101Phosphocysteine intermediateBy similarity1
Binding sitei107SubstrateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 2 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4a2
Protein-tyrosine phosphatase of regenerating liver 2
Short name:
PRL-2
Gene namesi
Name:Ptp4a2
Synonyms:Prl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1277117 Ptp4a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi164 – 167Missing : Locates in the nucleus. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947861 – 164Protein tyrosine phosphatase type IVA 2Add BLAST164
PropeptideiPRO_0000396732165 – 167Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 101By similarity
Modified residuei164Cysteine methyl esterCurated1
Lipidationi164S-farnesyl cysteine1 Publication1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO70274
MaxQBiO70274
PaxDbiO70274
PeptideAtlasiO70274
PRIDEiO70274

PTM databases

iPTMnetiO70274
PhosphoSitePlusiO70274

Expressioni

Tissue specificityi

Expressed in skeletal muscle, and at lower levels in liver, lung, heart, kidney, brain, testis and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000028788 Expressed in 313 organ(s), highest expression level in hindlimb zeugopod muscle
CleanExiMM_PTP4A2
GenevisibleiO70274 MM

Interactioni

Subunit structurei

In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB (By similarity).By similarity

Protein-protein interaction databases

BioGridi202474, 1 interactor
IntActiO70274, 1 interactor
MINTiO70274
STRINGi10090.ENSMUSP00000030578

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO70274
SMRiO70274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 145Tyrosine-protein phosphataseAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 107Phosphate bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836 Eukaryota
ENOG4111I7J LUCA
GeneTreeiENSGT00390000009788
HOGENOMiHOG000231265
HOVERGENiHBG071295
InParanoidiO70274
KOiK18041
OMAiAPIEKEG
OrthoDBiEOG091G0MYM
PhylomeDBiO70274
TreeFamiTF313384

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70274-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY
60 70 80 90 100
DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH
110 120 130 140 150
CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR
160
PKMRLRFRDT NGHCCVQ
Length:167
Mass (Da):19,127
Last modified:August 1, 1998 - v1
Checksum:iE97B88BF87B87943
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035644 mRNA Translation: AAC15874.1
AK033092 mRNA Translation: BAC28149.1
AK045093 mRNA Translation: BAC32217.1
AK155895 mRNA Translation: BAE33489.1
BC086794 mRNA Translation: AAH86794.1
BC087551 mRNA Translation: AAH87551.1
CCDSiCCDS18704.1
PIRiJC5981
RefSeqiNP_001158217.1, NM_001164745.1
NP_033000.1, NM_008974.4
XP_017175534.1, XM_017320045.1
UniGeneiMm.193688

Genome annotation databases

EnsembliENSMUST00000030578; ENSMUSP00000030578; ENSMUSG00000028788
ENSMUST00000165853; ENSMUSP00000125901; ENSMUSG00000028788
GeneIDi19244
KEGGimmu:19244
UCSCiuc008uyf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035644 mRNA Translation: AAC15874.1
AK033092 mRNA Translation: BAC28149.1
AK045093 mRNA Translation: BAC32217.1
AK155895 mRNA Translation: BAE33489.1
BC086794 mRNA Translation: AAH86794.1
BC087551 mRNA Translation: AAH87551.1
CCDSiCCDS18704.1
PIRiJC5981
RefSeqiNP_001158217.1, NM_001164745.1
NP_033000.1, NM_008974.4
XP_017175534.1, XM_017320045.1
UniGeneiMm.193688

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K24X-ray3.10A/B1-163[»]
ProteinModelPortaliO70274
SMRiO70274
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202474, 1 interactor
IntActiO70274, 1 interactor
MINTiO70274
STRINGi10090.ENSMUSP00000030578

PTM databases

iPTMnetiO70274
PhosphoSitePlusiO70274

Proteomic databases

EPDiO70274
MaxQBiO70274
PaxDbiO70274
PeptideAtlasiO70274
PRIDEiO70274

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030578; ENSMUSP00000030578; ENSMUSG00000028788
ENSMUST00000165853; ENSMUSP00000125901; ENSMUSG00000028788
GeneIDi19244
KEGGimmu:19244
UCSCiuc008uyf.2 mouse

Organism-specific databases

CTDi8073
MGIiMGI:1277117 Ptp4a2

Phylogenomic databases

eggNOGiKOG2836 Eukaryota
ENOG4111I7J LUCA
GeneTreeiENSGT00390000009788
HOGENOMiHOG000231265
HOVERGENiHBG071295
InParanoidiO70274
KOiK18041
OMAiAPIEKEG
OrthoDBiEOG091G0MYM
PhylomeDBiO70274
TreeFamiTF313384

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiPtp4a2 mouse
PROiPR:O70274
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028788 Expressed in 313 organ(s), highest expression level in hindlimb zeugopod muscle
CleanExiMM_PTP4A2
GenevisibleiO70274 MM

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTP4A2_MOUSE
AccessioniPrimary (citable) accession number: O70274
Secondary accession number(s): Q3U1K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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