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Protein

ETS homologous factor

Gene

Ehf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi207 – 289ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS homologous factor
Alternative name(s):
ETS domain-containing transcription factor
Gene namesi
Name:EhfImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1270840 Ehf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002579701 – 300ETS homologous factorAdd BLAST300

Proteomic databases

MaxQBiO70273
PaxDbiO70273
PeptideAtlasiO70273
PRIDEiO70273

PTM databases

PhosphoSitePlusiO70273

Expressioni

Tissue specificityi

Highly expressed in kidney and lung, weakly in skeletal muscle, heart, and liver, and not detected in brain, spleen or testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000012350 Expressed in 154 organ(s), highest expression level in submandibular gland
CleanExiMM_EHF
ExpressionAtlasiO70273 baseline and differential
GenevisibleiO70273 MM

Interactioni

Protein-protein interaction databases

BioGridi199409, 1 interactor
STRINGi10090.ENSMUSP00000087961

Structurei

3D structure databases

ProteinModelPortaliO70273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 115PNTPROSITE-ProRule annotationAdd BLAST87

Domaini

The PNT domain acts as a transcriptional activator.1 Publication

Sequence similaritiesi

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000232188
HOVERGENiHBG074143
InParanoidiO70273
KOiK17102
OrthoDBiEOG091G0BE6
PhylomeDBiO70273
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033071 EHF
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF171 PTHR11849:SF171, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: O70273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MILEGSGVMN LNPANNLLHQ QPAWTDSYPT CNVSSGFFGS QWHEIHPQYW
60 70 80 90 100
TKYQVWEWLQ HLLDTNQLDA SCIPFQEFDI SGEHLCSMSL QEFTRAAGSA
110 120 130 140 150
GQLLYSNLQH LKWNGQCSSD LFQSAHNVIV KTEQTDPSIM NTWKEENYLY
160 170 180 190 200
DPSYGSTVDL LDSKTFCRAQ ISMTTSSHLP VAESPDMKKE QDHPVKSHTK
210 220 230 240 250
KHNPRGTHLW EFIRDILLSP DKNPGLIKWE DRSEGIFRFL KSEAVAQLWG
260 270 280 290 300
KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
Length:300
Mass (Da):34,903
Last modified:August 1, 1998 - v1
Checksum:i91D9477EFB874747
GO
Isoform 21 Publication (identifier: O70273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-93: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:285
Mass (Da):33,225
Checksum:i91398C527C65955F
GO
Isoform 31 Publication (identifier: O70273-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-211: KKHNPRGTHLWE → YFIIELLLSESR
     212-300: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:211
Mass (Da):24,139
Checksum:i54F8846761D533CD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2BIB5A2BIB5_MOUSE
ETS homologous factor
Ehf
277Annotation score:
B0S7M9B0S7M9_MOUSE
ETS homologous factor
Ehf
242Annotation score:
A2BIB6A2BIB6_MOUSE
ETS homologous factor
Ehf
127Annotation score:
A2BIB7A2BIB7_MOUSE
ETS homologous factor
Ehf
181Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05219179 – 93Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_052192200 – 211KKHNP…THLWE → YFIIELLLSESR in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_052193212 – 300Missing in isoform 3. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035527 mRNA Translation: AAC40119.1
BC005520 mRNA Translation: AAH05520.1
BC006789 mRNA Translation: AAH06789.1
BC008249 mRNA Translation: AAH08249.1
CCDSiCCDS16475.1 [O70273-1]
PIRiJW0048
RefSeqiNP_031940.1, NM_007914.3 [O70273-1]
XP_006498760.1, XM_006498697.2 [O70273-1]
XP_006498761.1, XM_006498698.3 [O70273-1]
XP_006498762.1, XM_006498699.1 [O70273-1]
XP_006498763.1, XM_006498700.3 [O70273-1]
XP_006498764.1, XM_006498701.3 [O70273-1]
XP_006498765.1, XM_006498702.3 [O70273-1]
UniGeneiMm.10724

Genome annotation databases

EnsembliENSMUST00000090475; ENSMUSP00000087961; ENSMUSG00000012350 [O70273-1]
ENSMUST00000111174; ENSMUSP00000106805; ENSMUSG00000012350 [O70273-1]
GeneIDi13661
KEGGimmu:13661
UCSCiuc008lio.1 mouse [O70273-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035527 mRNA Translation: AAC40119.1
BC005520 mRNA Translation: AAH05520.1
BC006789 mRNA Translation: AAH06789.1
BC008249 mRNA Translation: AAH08249.1
CCDSiCCDS16475.1 [O70273-1]
PIRiJW0048
RefSeqiNP_031940.1, NM_007914.3 [O70273-1]
XP_006498760.1, XM_006498697.2 [O70273-1]
XP_006498761.1, XM_006498698.3 [O70273-1]
XP_006498762.1, XM_006498699.1 [O70273-1]
XP_006498763.1, XM_006498700.3 [O70273-1]
XP_006498764.1, XM_006498701.3 [O70273-1]
XP_006498765.1, XM_006498702.3 [O70273-1]
UniGeneiMm.10724

3D structure databases

ProteinModelPortaliO70273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199409, 1 interactor
STRINGi10090.ENSMUSP00000087961

PTM databases

PhosphoSitePlusiO70273

Proteomic databases

MaxQBiO70273
PaxDbiO70273
PeptideAtlasiO70273
PRIDEiO70273

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090475; ENSMUSP00000087961; ENSMUSG00000012350 [O70273-1]
ENSMUST00000111174; ENSMUSP00000106805; ENSMUSG00000012350 [O70273-1]
GeneIDi13661
KEGGimmu:13661
UCSCiuc008lio.1 mouse [O70273-1]

Organism-specific databases

CTDi26298
MGIiMGI:1270840 Ehf

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000232188
HOVERGENiHBG074143
InParanoidiO70273
KOiK17102
OrthoDBiEOG091G0BE6
PhylomeDBiO70273
TreeFamiTF318679

Miscellaneous databases

PROiPR:O70273
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000012350 Expressed in 154 organ(s), highest expression level in submandibular gland
CleanExiMM_EHF
ExpressionAtlasiO70273 baseline and differential
GenevisibleiO70273 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033071 EHF
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF171 PTHR11849:SF171, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEHF_MOUSE
AccessioniPrimary (citable) accession number: O70273
Secondary accession number(s): Q922E8, Q922T6, Q99K12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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