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Protein

Heme oxygenase 2

Gene

Hmox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • heme binding Source: GO_Central
  • heme oxygenase (decyclizing) activity Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.99.3 3474
ReactomeiR-MMU-189483 Heme degradation
R-MMU-6798695 Neutrophil degranulation
R-MMU-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 2 (EC:1.14.14.18By similarity)
Short name:
HO-2
Gene namesi
Name:Hmox2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:109373 Hmox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002096922 – 315Heme oxygenase 2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70252
PaxDbiO70252
PeptideAtlasiO70252
PRIDEiO70252

PTM databases

iPTMnetiO70252
PhosphoSitePlusiO70252
SwissPalmiO70252

Expressioni

Gene expression databases

BgeeiENSMUSG00000004070 Expressed in 311 organ(s), highest expression level in testis
CleanExiMM_HMOX2
ExpressionAtlasiO70252 baseline and differential
GenevisibleiO70252 MM

Interactioni

Protein-protein interaction databases

IntActiO70252, 3 interactors
MINTiO70252
STRINGi10090.ENSMUSP00000004172

Structurei

3D structure databases

ProteinModelPortaliO70252
SMRiO70252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati263 – 268HRM 16
Repeati280 – 285HRM 26

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4480 Eukaryota
COG5398 LUCA
GeneTreeiENSGT00390000017673
HOGENOMiHOG000233221
HOVERGENiHBG005982
InParanoidiO70252
KOiK21418
OMAiKENHTRM
OrthoDBiEOG091G0AS0
PhylomeDBiO70252
TreeFamiTF314786

Family and domain databases

CDDicd00232 HemeO, 1 hit
Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR002051 Haem_Oase
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR018207 Haem_oxygenase_CS
PANTHERiPTHR10720 PTHR10720, 1 hit
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
PIRSFiPIRSF000343 Haem_Oase, 1 hit
PRINTSiPR00088 HAEMOXYGNASE
SUPFAMiSSF48613 SSF48613, 1 hit
PROSITEiView protein in PROSITE
PS00593 HEME_OXYGENASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O70252-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEVETSEG VDESEKNSMA PEKENHTKMA DLSELLKEGT KEAHDRAENT
60 70 80 90 100
QFVKDFLKGN IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT
110 120 130 140 150
ELHRKAALIK DMKYFFGENW EEQVKCSEAA QKYVDRIHYV GQNEPELLVA
160 170 180 190 200
HAYTRYMGDL SGGQVLKKVA QRALKLPSTG EGTQFYLFEH VDNAQQFKQF
210 220 230 240 250
YRARMNALDL NLKTKERIVE EANKAFEYNM QIFSELDQAG SMLARETLED
260 270 280 290 300
GLPVHDGKGD IRKCPFYAAQ PDKGTLGGSN CPFQTTVAVL RKPSLQLILA
310
ASVALVAGLL AWYYM
Length:315
Mass (Da):35,739
Last modified:August 1, 1998 - v1
Checksum:iEA382EB2C7CED6D1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YX62D3YX62_MOUSE
Heme oxygenase 2
Hmox2
228Annotation score:
D3Z4A2D3Z4A2_MOUSE
Heme oxygenase 2
Hmox2
65Annotation score:
D3YXN4D3YXN4_MOUSE
Heme oxygenase 2
Hmox2
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172 – 174RAL → SSS in AAC82364 (PubMed:9795203).Curated3
Sequence conflicti172 – 174RAL → SSS in AAC82363 (PubMed:9795203).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029874 mRNA Translation: AAC17981.1
AF054670 mRNA Translation: AAC82364.1
AF054669 mRNA Translation: AAC82363.1
BC002011 mRNA Translation: AAH02011.1
CCDSiCCDS27924.1
PIRiJC5149
RefSeqiNP_001129538.1, NM_001136066.2
NP_034573.2, NM_010443.2
UniGeneiMm.272866

Genome annotation databases

EnsembliENSMUST00000004172; ENSMUSP00000004172; ENSMUSG00000004070
ENSMUST00000118885; ENSMUSP00000113110; ENSMUSG00000004070
ENSMUST00000120232; ENSMUSP00000112397; ENSMUSG00000004070
GeneIDi15369
KEGGimmu:15369
UCSCiuc007yag.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029874 mRNA Translation: AAC17981.1
AF054670 mRNA Translation: AAC82364.1
AF054669 mRNA Translation: AAC82363.1
BC002011 mRNA Translation: AAH02011.1
CCDSiCCDS27924.1
PIRiJC5149
RefSeqiNP_001129538.1, NM_001136066.2
NP_034573.2, NM_010443.2
UniGeneiMm.272866

3D structure databases

ProteinModelPortaliO70252
SMRiO70252
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70252, 3 interactors
MINTiO70252
STRINGi10090.ENSMUSP00000004172

PTM databases

iPTMnetiO70252
PhosphoSitePlusiO70252
SwissPalmiO70252

Proteomic databases

EPDiO70252
PaxDbiO70252
PeptideAtlasiO70252
PRIDEiO70252

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004172; ENSMUSP00000004172; ENSMUSG00000004070
ENSMUST00000118885; ENSMUSP00000113110; ENSMUSG00000004070
ENSMUST00000120232; ENSMUSP00000112397; ENSMUSG00000004070
GeneIDi15369
KEGGimmu:15369
UCSCiuc007yag.2 mouse

Organism-specific databases

CTDi3163
MGIiMGI:109373 Hmox2

Phylogenomic databases

eggNOGiKOG4480 Eukaryota
COG5398 LUCA
GeneTreeiENSGT00390000017673
HOGENOMiHOG000233221
HOVERGENiHBG005982
InParanoidiO70252
KOiK21418
OMAiKENHTRM
OrthoDBiEOG091G0AS0
PhylomeDBiO70252
TreeFamiTF314786

Enzyme and pathway databases

BRENDAi1.14.99.3 3474
ReactomeiR-MMU-189483 Heme degradation
R-MMU-6798695 Neutrophil degranulation
R-MMU-917937 Iron uptake and transport

Miscellaneous databases

PROiPR:O70252
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004070 Expressed in 311 organ(s), highest expression level in testis
CleanExiMM_HMOX2
ExpressionAtlasiO70252 baseline and differential
GenevisibleiO70252 MM

Family and domain databases

CDDicd00232 HemeO, 1 hit
Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR002051 Haem_Oase
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR018207 Haem_oxygenase_CS
PANTHERiPTHR10720 PTHR10720, 1 hit
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
PIRSFiPIRSF000343 Haem_Oase, 1 hit
PRINTSiPR00088 HAEMOXYGNASE
SUPFAMiSSF48613 SSF48613, 1 hit
PROSITEiView protein in PROSITE
PS00593 HEME_OXYGENASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMOX2_MOUSE
AccessioniPrimary (citable) accession number: O70252
Secondary accession number(s): O70626
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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