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Protein

Elongation factor 1-beta

Gene

Eef1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.By similarity

GO - Molecular functioni

  • translation elongation factor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-beta
Short name:
EF-1-beta
Gene namesi
Name:Eef1b
Synonyms:Eef1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929520 Eef1b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001550222 – 225Elongation factor 1-betaAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N6-acetyllysineBy similarity1
Modified residuei42PhosphoserineBy similarity1
Modified residuei83PhosphoserineCombined sources1
Modified residuei88PhosphothreonineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei174PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO70251
MaxQBiO70251
PaxDbiO70251
PeptideAtlasiO70251
PRIDEiO70251
TopDownProteomicsiO70251

PTM databases

iPTMnetiO70251
PhosphoSitePlusiO70251
SwissPalmiO70251

Expressioni

Gene expression databases

BgeeiENSMUSG00000025967 Expressed in 57 organ(s), highest expression level in thymus
CleanExiMM_EEF1B2
ExpressionAtlasiO70251 baseline and differential
GenevisibleiO70251 MM

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.By similarity

Protein-protein interaction databases

BioGridi207744, 7 interactors
DIPiDIP-32121N
IntActiO70251, 7 interactors
MINTiO70251
STRINGi10090.ENSMUSP00000116492

Structurei

3D structure databases

ProteinModelPortaliO70251
SMRiO70251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 90GST C-terminalAdd BLAST89

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGiKOG1668 Eukaryota
COG2092 LUCA
GeneTreeiENSGT00390000011747
HOGENOMiHOG000207273
HOVERGENiHBG000787
InParanoidiO70251
KOiK03232
OMAiKICKFPG
OrthoDBiEOG091G0P0Z
PhylomeDBiO70251
TreeFamiTF313134

Family and domain databases

CDDicd00292 EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR036282 Glutathione-S-Trfase_C_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF54984 SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

O70251-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFGDLKTPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSGPPPADLC
60 70 80 90 100
HALRWYNHIK SYEKEKASLP GVKKSLGKYG PSSVEDTTGS GAADAKDDDD
110 120 130 140 150
IDLFGSDDEE ESEEAKKLRE ERLAQYESKK AKKPAVVAKS SILLDVKPWD
160 170 180 190 200
DETDMTKLEE CVRSIQADGL VWGSSKLVPV GYGIKKLQIQ CVVEDDKVGT
210 220
DMLEEQITAF EDYVQSMDVA AFNKI
Length:225
Mass (Da):24,694
Last modified:January 23, 2007 - v5
Checksum:i6E497150AD88F887
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WS46A0A087WS46_MOUSE
Eukaryotic translation elongation f...
Eef1b2
184Annotation score:
M0QW60M0QW60_MOUSE
Eukaryotic translation elongation f...
Eef1b2
68Annotation score:
G3UX43G3UX43_MOUSE
Eukaryotic translation elongation f...
Eef1b2
68Annotation score:
M0QWH8M0QWH8_MOUSE
Eukaryotic translation elongation f...
Eef1b2
48Annotation score:
G3UZ47G3UZ47_MOUSE
Eukaryotic translation elongation f...
Eef1b2
94Annotation score:
M0QWK5M0QWK5_MOUSE
Eukaryotic translation elongation f...
Eef1b2
43Annotation score:

Sequence cautioni

The sequence AAH39635 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113E → G in BAB28447 (PubMed:16141072).Curated1
Sequence conflicti116K → E in AAC13264 (Ref. 1) Curated1
Sequence conflicti136V → I in AAC13264 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029844 mRNA Translation: AAC13264.2
AK012756 mRNA Translation: BAB28447.1
AK027911 mRNA Translation: BAC25661.1
AK168191 mRNA Translation: BAE40151.1
AL645950 Genomic DNA No translation available.
BC003899 mRNA Translation: AAH03899.1
BC023139 mRNA Translation: AAH23139.1
BC039635 mRNA Translation: AAH39635.1 Different initiation.
CCDSiCCDS14997.1
PIRiPC7074
RefSeqiNP_061266.2, NM_018796.3
UniGeneiMm.2718

Genome annotation databases

EnsembliENSMUST00000129339; ENSMUSP00000116492; ENSMUSG00000025967
GeneIDi55949
KEGGimmu:55949
UCSCiuc007bfz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029844 mRNA Translation: AAC13264.2
AK012756 mRNA Translation: BAB28447.1
AK027911 mRNA Translation: BAC25661.1
AK168191 mRNA Translation: BAE40151.1
AL645950 Genomic DNA No translation available.
BC003899 mRNA Translation: AAH03899.1
BC023139 mRNA Translation: AAH23139.1
BC039635 mRNA Translation: AAH39635.1 Different initiation.
CCDSiCCDS14997.1
PIRiPC7074
RefSeqiNP_061266.2, NM_018796.3
UniGeneiMm.2718

3D structure databases

ProteinModelPortaliO70251
SMRiO70251
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207744, 7 interactors
DIPiDIP-32121N
IntActiO70251, 7 interactors
MINTiO70251
STRINGi10090.ENSMUSP00000116492

PTM databases

iPTMnetiO70251
PhosphoSitePlusiO70251
SwissPalmiO70251

Proteomic databases

EPDiO70251
MaxQBiO70251
PaxDbiO70251
PeptideAtlasiO70251
PRIDEiO70251
TopDownProteomicsiO70251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000129339; ENSMUSP00000116492; ENSMUSG00000025967
GeneIDi55949
KEGGimmu:55949
UCSCiuc007bfz.2 mouse

Organism-specific databases

CTDi1933
MGIiMGI:1929520 Eef1b2

Phylogenomic databases

eggNOGiKOG1668 Eukaryota
COG2092 LUCA
GeneTreeiENSGT00390000011747
HOGENOMiHOG000207273
HOVERGENiHBG000787
InParanoidiO70251
KOiK03232
OMAiKICKFPG
OrthoDBiEOG091G0P0Z
PhylomeDBiO70251
TreeFamiTF313134

Miscellaneous databases

ChiTaRSiEef1b2 mouse
PROiPR:O70251
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025967 Expressed in 57 organ(s), highest expression level in thymus
CleanExiMM_EEF1B2
ExpressionAtlasiO70251 baseline and differential
GenevisibleiO70251 MM

Family and domain databases

CDDicd00292 EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR036282 Glutathione-S-Trfase_C_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF54984 SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEF1B_MOUSE
AccessioniPrimary (citable) accession number: O70251
Secondary accession number(s): Q3THP5
, Q5SUH1, Q8CHS1, Q99L22, Q9CZD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 156 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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