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Protein

Phosphoglycerate mutase 2

Gene

Pgam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.By similarity
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Tele-phosphohistidine intermediateBy similarity1
Binding sitei62SubstrateBy similarity1
Active sitei89Proton donor/acceptorBy similarity1
Binding sitei100SubstrateBy similarity1
Sitei186Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Isomerase
Biological processGlycolysis

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate mutase 2 (EC:5.4.2.11By similarity, EC:5.4.2.4By similarity)
Alternative name(s):
BPG-dependent PGAM 2
Muscle-specific phosphoglycerate mutase
Phosphoglycerate mutase isozyme M
Short name:
PGAM-M
Gene namesi
Name:Pgam2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1933118 Pgam2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001798301 – 253Phosphoglycerate mutase 2Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei118PhosphoserineCombined sources1
Modified residuei121PhosphothreonineBy similarity1
Modified residuei132PhosphotyrosineBy similarity1
Modified residuei133PhosphotyrosineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei152PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70250
PeptideAtlasiO70250
PRIDEiO70250

2D gel databases

SWISS-2DPAGEiO70250

PTM databases

iPTMnetiO70250
PhosphoSitePlusiO70250
SwissPalmiO70250

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000020475 Expressed in 207 organ(s), highest expression level in triceps surae
CleanExiMM_PGAM2
ExpressionAtlasiO70250 baseline and differential
GenevisibleiO70250 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with ENO1 (PubMed:23446454).By similarity1 Publication

Protein-protein interaction databases

BioGridi207767, 3 interactors
IntActiO70250, 3 interactors
MINTiO70250
STRINGi10090.ENSMUSP00000020768

Structurei

3D structure databases

ProteinModelPortaliO70250
SMRiO70250
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 17Substrate bindingBy similarity8
Regioni23 – 24Substrate bindingBy similarity2
Regioni89 – 92Substrate bindingBy similarity4
Regioni116 – 117Substrate bindingBy similarity2
Regioni187 – 188Substrate bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Pro4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0235 Eukaryota
COG0588 LUCA
GeneTreeiENSGT00390000016700
HOGENOMiHOG000221682
HOVERGENiHBG027528
InParanoidiO70250
KOiK01834
OMAiWTILDGT
OrthoDBiEOG091G0GIS
PhylomeDBiO70250
TreeFamiTF300007

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

O70250-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTHRLVMVR HGESLWNQEN RFCGWFDAEL SEKGAEEAKR GATAIKDAKI
60 70 80 90 100
EFDICYTSVL KRAIRTLWTI LDVTDQMWVP VVRTWRLNER HYGGLTGLNK
110 120 130 140 150
AETAAKHGEE QVKIWRRSFD TPPPPMDEKH NYYTSISKDR RYAGLKPEEL
160 170 180 190 200
PTCESLKDTI ARALPFWNEE IAPKIKAGQR VLIAAHGNSL RGIVKHLEGM
210 220 230 240 250
SDQAIMELNL PTGIPIVYEL DQNLKPTKPM RFLGDEETVR KAMEAVAAQG

KAK
Length:253
Mass (Da):28,827
Last modified:January 23, 2007 - v3
Checksum:i477AF9EC59A15B86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029843 mRNA Translation: AAC13263.1
AF317587 Genomic DNA Translation: AAK06662.1
BC010750 mRNA Translation: AAH10750.1
CCDSiCCDS24404.1
RefSeqiNP_061358.1, NM_018870.3
UniGeneiMm.219627

Genome annotation databases

EnsembliENSMUST00000020768; ENSMUSP00000020768; ENSMUSG00000020475
GeneIDi56012
KEGGimmu:56012
UCSCiuc007hxe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029843 mRNA Translation: AAC13263.1
AF317587 Genomic DNA Translation: AAK06662.1
BC010750 mRNA Translation: AAH10750.1
CCDSiCCDS24404.1
RefSeqiNP_061358.1, NM_018870.3
UniGeneiMm.219627

3D structure databases

ProteinModelPortaliO70250
SMRiO70250
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207767, 3 interactors
IntActiO70250, 3 interactors
MINTiO70250
STRINGi10090.ENSMUSP00000020768

PTM databases

iPTMnetiO70250
PhosphoSitePlusiO70250
SwissPalmiO70250

2D gel databases

SWISS-2DPAGEiO70250

Proteomic databases

PaxDbiO70250
PeptideAtlasiO70250
PRIDEiO70250

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020768; ENSMUSP00000020768; ENSMUSG00000020475
GeneIDi56012
KEGGimmu:56012
UCSCiuc007hxe.2 mouse

Organism-specific databases

CTDi5224
MGIiMGI:1933118 Pgam2

Phylogenomic databases

eggNOGiKOG0235 Eukaryota
COG0588 LUCA
GeneTreeiENSGT00390000016700
HOGENOMiHOG000221682
HOVERGENiHBG027528
InParanoidiO70250
KOiK01834
OMAiWTILDGT
OrthoDBiEOG091G0GIS
PhylomeDBiO70250
TreeFamiTF300007

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis

Miscellaneous databases

ChiTaRSiPgam2 mouse
PROiPR:O70250
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020475 Expressed in 207 organ(s), highest expression level in triceps surae
CleanExiMM_PGAM2
ExpressionAtlasiO70250 baseline and differential
GenevisibleiO70250 MM

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGAM2_MOUSE
AccessioniPrimary (citable) accession number: O70250
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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