UniProtKB - O70248 (APBA3_RAT)
Protein
Amyloid-beta A4 precursor protein-binding family A member 3
Gene
Apba3
Organism
Rattus norvegicus (Rat)
Status
Functioni
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).By similarity
GO - Molecular functioni
- amyloid-beta binding Source: RGD
- enzyme binding Source: RGD
- enzyme inhibitor activity Source: RGD
GO - Biological processi
- chemical synaptic transmission Source: RGD
- in utero embryonic development Source: RGD
- negative regulation of catalytic activity Source: RGD
- protein transport Source: UniProtKB-KW
- regulation of gene expression Source: RGD
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Amyloid-beta A4 precursor protein-binding family A member 3Alternative name(s): Adapter protein X11gamma Neuron-specific X11L2 protein Neuronal Munc18-1-interacting protein 3 Short name: Mint-3 |
Gene namesi | Name:Apba3 Synonyms:Mint3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620846, Apba3 |
Subcellular locationi
Other locations
- perinuclear region By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- dendritic spine Source: GO_Central
- perinuclear region of cytoplasm Source: RGD
- synapse Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064622 | 1 – 569 | Amyloid-beta A4 precursor protein-binding family A member 3Add BLAST | 569 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 367 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | O70248 |
PRIDEi | O70248 |
PTM databases
iPTMneti | O70248 |
PhosphoSitePlusi | O70248 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSRNOG00000020466, Expressed in liver and 21 other tissues |
Genevisiblei | O70248, RN |
Interactioni
Subunit structurei
Binds to the cytoplasmic domain of amyloid protein (APP).
Interacts with HIF1AN (via N-terminus) (By similarity).
Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN (By similarity).
By similarityGO - Molecular functioni
- enzyme binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249776, 1 interactor |
IntActi | O70248, 4 interactors |
MINTi | O70248 |
STRINGi | 10116.ENSRNOP00000027784 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 212 – 376 | PIDPROSITE-ProRule annotationAdd BLAST | 165 | |
Domaini | 389 – 475 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 480 – 554 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 75 |
Domaini
Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3605, Eukaryota |
GeneTreei | ENSGT00940000160384 |
HOGENOMi | CLU_013563_2_0_1 |
InParanoidi | O70248 |
OMAi | YPAPQEV |
OrthoDBi | 436779at2759 |
TreeFami | TF315245 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR030531, Apba3 IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
PANTHERi | PTHR12345:SF9, PTHR12345:SF9, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits SM00462, PTB, 1 hit |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits PS01179, PID, 1 hit |
i Sequence
Sequence statusi: Complete.
O70248-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFLPEPQHP PGPPTMDLEE PKGPEVPSED HPSNTQWALG PRGPDTLSEM
60 70 80 90 100
ELDTSSVRAL VQQLEALPSD LGGQFPDGAP CPLHIATGQG LATQENLDAG
110 120 130 140 150
GLLSAEAGGD NLLGLLRCEA SLPAQSVPPD PAQAAPRLLQ PPEDPGGDPG
160 170 180 190 200
WMEGTEPADN RSSSSSPELW LETAPLVTHR DPPVGTQSQE TLASCPAVSE
210 220 230 240 250
VPGPCGQEEL MDGVLFGAKY LGSTQLLSER NPPPSTRMGQ AQEAMDRVKA
260 270 280 290 300
PEGETQPMTE VDIFISTKRV KVLAADSQDA LMDHALQTIS YIADIGPVLV
310 320 330 340 350
LMARRRLAKR TTSQDRQRQL YKMLCHVFHS EDAQLIAQAI GQAFSIAYSQ
360 370 380 390 400
FLQENRIDPS QVGMQPSASA SHPHNGDLDH FCNSQNCREV CIQKRPGEGL
410 420 430 440 450
GVALVESGWG SLLPTAVIAN LLHGGPAERC GALSIGDRVT AINGTSLVGL
460 470 480 490 500
SLAACQAAVR EVRRHSSVTL SIIHCPPVTT AVIHRPHVRE QLGFCVENGI
510 520 530 540 550
ICSLLRGSAA ERGGVRVGHR IIEVNGQSVV AMPHARIIQL LTETREIHIK
560
TMPAATYRLL TGQEQPVYL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | W → G in AAC17978 (PubMed:9860131).Curated | 1 | |
Sequence conflicti | 255 | T → S in AAC17978 (PubMed:9860131).Curated | 1 | |
Sequence conflicti | 356 | R → G in AAC17978 (PubMed:9860131).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029109 mRNA Translation: AAC17978.1 CH474029 Genomic DNA Translation: EDL89170.1 BC161842 mRNA Translation: AAI61842.1 |
RefSeqi | NP_113969.1, NM_031781.1 XP_006241082.1, XM_006241020.2 |
Genome annotation databases
Ensembli | ENSRNOT00000027784; ENSRNOP00000027784; ENSRNOG00000020466 |
GeneIDi | 83611 |
KEGGi | rno:83611 |
UCSCi | RGD:620846, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029109 mRNA Translation: AAC17978.1 CH474029 Genomic DNA Translation: EDL89170.1 BC161842 mRNA Translation: AAI61842.1 |
RefSeqi | NP_113969.1, NM_031781.1 XP_006241082.1, XM_006241020.2 |
3D structure databases
SMRi | O70248 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249776, 1 interactor |
IntActi | O70248, 4 interactors |
MINTi | O70248 |
STRINGi | 10116.ENSRNOP00000027784 |
PTM databases
iPTMneti | O70248 |
PhosphoSitePlusi | O70248 |
Proteomic databases
PaxDbi | O70248 |
PRIDEi | O70248 |
Genome annotation databases
Ensembli | ENSRNOT00000027784; ENSRNOP00000027784; ENSRNOG00000020466 |
GeneIDi | 83611 |
KEGGi | rno:83611 |
UCSCi | RGD:620846, rat |
Organism-specific databases
CTDi | 9546 |
RGDi | 620846, Apba3 |
Phylogenomic databases
eggNOGi | KOG3605, Eukaryota |
GeneTreei | ENSGT00940000160384 |
HOGENOMi | CLU_013563_2_0_1 |
InParanoidi | O70248 |
OMAi | YPAPQEV |
OrthoDBi | 436779at2759 |
TreeFami | TF315245 |
Miscellaneous databases
PROi | PR:O70248 |
Gene expression databases
Bgeei | ENSRNOG00000020466, Expressed in liver and 21 other tissues |
Genevisiblei | O70248, RN |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR030531, Apba3 IPR001478, PDZ IPR036034, PDZ_sf IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom |
PANTHERi | PTHR12345:SF9, PTHR12345:SF9, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits PF00640, PID, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits SM00462, PTB, 1 hit |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits PS01179, PID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | APBA3_RAT | |
Accessioni | O70248Primary (citable) accession number: O70248 Secondary accession number(s): B1WBQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | April 18, 2012 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |