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Protein

Amyloid-beta A4 precursor protein-binding family A member 3

Gene

Apba3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).By similarity

GO - Molecular functioni

  • amyloid-beta binding Source: RGD
  • enzyme binding Source: Ensembl
  • enzyme inhibitor activity Source: Ensembl

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family A member 3
Alternative name(s):
Adapter protein X11gamma
Neuron-specific X11L2 protein
Neuronal Munc18-1-interacting protein 3
Short name:
Mint-3
Gene namesi
Name:Apba3
Synonyms:Mint3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620846 Apba3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646221 – 569Amyloid-beta A4 precursor protein-binding family A member 3Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei166PhosphoserineCombined sources1
Modified residuei367PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70248
PRIDEiO70248

PTM databases

iPTMnetiO70248
PhosphoSitePlusiO70248

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000020466 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO70248 RN

Interactioni

Subunit structurei

Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity). Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249776, 1 interactor
MINTiO70248
STRINGi10116.ENSRNOP00000027784

Structurei

3D structure databases

ProteinModelPortaliO70248
SMRiO70248
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 376PIDPROSITE-ProRule annotationAdd BLAST165
Domaini389 – 475PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini480 – 554PDZ 2PROSITE-ProRule annotationAdd BLAST75

Domaini

Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3605 Eukaryota
ENOG410XSBD LUCA
GeneTreeiENSGT00390000013578
HOGENOMiHOG000033981
HOVERGENiHBG050523
InParanoidiO70248
OMAiLYKMICH
OrthoDBiEOG091G0PDJ
TreeFamiTF315245

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030531 Apba3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR12345:SF9 PTHR12345:SF9, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit

Sequencei

Sequence statusi: Complete.

O70248-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFLPEPQHP PGPPTMDLEE PKGPEVPSED HPSNTQWALG PRGPDTLSEM
60 70 80 90 100
ELDTSSVRAL VQQLEALPSD LGGQFPDGAP CPLHIATGQG LATQENLDAG
110 120 130 140 150
GLLSAEAGGD NLLGLLRCEA SLPAQSVPPD PAQAAPRLLQ PPEDPGGDPG
160 170 180 190 200
WMEGTEPADN RSSSSSPELW LETAPLVTHR DPPVGTQSQE TLASCPAVSE
210 220 230 240 250
VPGPCGQEEL MDGVLFGAKY LGSTQLLSER NPPPSTRMGQ AQEAMDRVKA
260 270 280 290 300
PEGETQPMTE VDIFISTKRV KVLAADSQDA LMDHALQTIS YIADIGPVLV
310 320 330 340 350
LMARRRLAKR TTSQDRQRQL YKMLCHVFHS EDAQLIAQAI GQAFSIAYSQ
360 370 380 390 400
FLQENRIDPS QVGMQPSASA SHPHNGDLDH FCNSQNCREV CIQKRPGEGL
410 420 430 440 450
GVALVESGWG SLLPTAVIAN LLHGGPAERC GALSIGDRVT AINGTSLVGL
460 470 480 490 500
SLAACQAAVR EVRRHSSVTL SIIHCPPVTT AVIHRPHVRE QLGFCVENGI
510 520 530 540 550
ICSLLRGSAA ERGGVRVGHR IIEVNGQSVV AMPHARIIQL LTETREIHIK
560
TMPAATYRLL TGQEQPVYL
Length:569
Mass (Da):60,882
Last modified:April 18, 2012 - v2
Checksum:iA3DA45F4B2BBB338
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37W → G in AAC17978 (PubMed:9860131).Curated1
Sequence conflicti255T → S in AAC17978 (PubMed:9860131).Curated1
Sequence conflicti356R → G in AAC17978 (PubMed:9860131).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029109 mRNA Translation: AAC17978.1
CH474029 Genomic DNA Translation: EDL89170.1
BC161842 mRNA Translation: AAI61842.1
RefSeqiNP_113969.1, NM_031781.1
XP_006241082.1, XM_006241020.2
UniGeneiRn.6924

Genome annotation databases

EnsembliENSRNOT00000027784; ENSRNOP00000027784; ENSRNOG00000020466
GeneIDi83611
KEGGirno:83611
UCSCiRGD:620846 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029109 mRNA Translation: AAC17978.1
CH474029 Genomic DNA Translation: EDL89170.1
BC161842 mRNA Translation: AAI61842.1
RefSeqiNP_113969.1, NM_031781.1
XP_006241082.1, XM_006241020.2
UniGeneiRn.6924

3D structure databases

ProteinModelPortaliO70248
SMRiO70248
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249776, 1 interactor
MINTiO70248
STRINGi10116.ENSRNOP00000027784

PTM databases

iPTMnetiO70248
PhosphoSitePlusiO70248

Proteomic databases

PaxDbiO70248
PRIDEiO70248

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027784; ENSRNOP00000027784; ENSRNOG00000020466
GeneIDi83611
KEGGirno:83611
UCSCiRGD:620846 rat

Organism-specific databases

CTDi9546
RGDi620846 Apba3

Phylogenomic databases

eggNOGiKOG3605 Eukaryota
ENOG410XSBD LUCA
GeneTreeiENSGT00390000013578
HOGENOMiHOG000033981
HOVERGENiHBG050523
InParanoidiO70248
OMAiLYKMICH
OrthoDBiEOG091G0PDJ
TreeFamiTF315245

Miscellaneous databases

PROiPR:O70248

Gene expression databases

BgeeiENSRNOG00000020466 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO70248 RN

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030531 Apba3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR12345:SF9 PTHR12345:SF9, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPBA3_RAT
AccessioniPrimary (citable) accession number: O70248
Secondary accession number(s): B1WBQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 18, 2012
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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