Znf143

Functionⁱ

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	237 – 261	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	267 – 291	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	297 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	327 – 351	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	357 – 381	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	387 – 411	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	417 – 440	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

chromatin binding Source: MGI
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 14667815
metal ion binding Source: UniProtKB-KW
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of smooth muscle cell proliferation Source: MGI
positive regulation of transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6807505 RNA polymerase II transcribes snRNA genes R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Reactomeⁱ

R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 143 Short name: Zfp-143 Alternative name(s): Selenocysteine tRNA gene transcription-activating factor Short name: mStaf
Gene namesⁱ	Name:Znf143 Synonyms:Staf, Zfp143
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1277969 Zfp143

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000248071	1 – 638	Zinc finger protein 143Add BLAST		638

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Cross-linkⁱ	213	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	352	PhosphothreonineBy similarity	1
Cross-linkⁱ	406	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O70230
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O70230
PaxDbⁱ	O70230
PeptideAtlas More...PeptideAtlasⁱ	O70230
PRIDEⁱ	O70230

PTM databases

iPTMnetⁱ	O70230
PhosphoSitePlusⁱ	O70230

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000061079 Expressed in 273 organ(s), highest expression level in embryo
CleanExⁱ	MM_ZFP143
Genevisibleⁱ	O70230 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CHD8.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Sall4	Q8BX22	2	EBI-5691478,EBI-2312582

With

Entry

#Exp.

IntAct

Notes

Sall4

Q8BX22

2

EBI-5691478,EBI-2312582

Protein-protein interaction databases

BioGridⁱ	203516, 4 interactors
IntActⁱ	O70230, 3 interactors
STRINGⁱ	10090.ENSMUSP00000081778

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O70230
SMRⁱ	O70230
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	237 – 261	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	267 – 291	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	297 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	327 – 351	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	357 – 381	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	387 – 411	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	417 – 440	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000118073
HOVERGENⁱ	HBG053078
InParanoidⁱ	O70230
KEGG Orthology (KO) More...KOⁱ	K20828
OMAⁱ	KMQIVLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N38
PhylomeDBⁱ	O70230
TreeFamⁱ	TF333498

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O70230-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL 
        60         70         80         90        100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSTGDS 
       110        120        130        140        150
LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS SLQAVQLEDG TTAYIHHAVQ 
       160        170        180        190        200
VPQSDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSDGVT 
       210        220        230        240        250
STGMIGENEQ EKKMQIVLQG HATRVTPKSQ QSGEKAFRCK YDGCGKLYTT 
       260        270        280        290        300
AHHLKVHERS HTGDRPYQCE HSGCGKAFAT GYGLKSHFRT HTGEKPYRCS 
       310        320        330        340        350
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP IEGCGRSFTT SNIRKVHIRT 
       360        370        380        390        400
HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE 
       410        420        430        440        450
YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ 
       460        470        480        490        500
EAFFEPPPGQ GDDVLKGSQI TYVTGVDGED IVSTQVATVT QSGLSQQVTL 
       510        520        530        540        550
ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPTHDA VISSAGTHSV 
       560        570        580        590        600
AMVTAEGTEG QQVAIVAQDL AAFHTASSEM GHQQHSHHLV TTETRPLTLV 
       610        620        630 
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD

Length:638

Mass (Da):69,040

Last modified:May 5, 2009 - v2

Checksum:ⁱ9BDA0B6C0EBC0634

GO

Isoform 2 (identifier: O70230-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
97-98: TG → R

« Hide

        10         20         30         40         50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL 
        60         70         80         90        100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSRDSL 
       110        120        130        140        150
RLEDGQAVQL EDGTTAFIHH TSKDSYDQSS LQAVQLEDGT TAYIHHAVQV 
       160        170        180        190        200
PQSDTILAIQ ADGTVAGLHT GDATIDPDTI SALEQYAAKV SIDGSDGVTS 
       210        220        230        240        250
TGMIGENEQE KKMQIVLQGH ATRVTPKSQQ SGEKAFRCKY DGCGKLYTTA 
       260        270        280        290        300
HHLKVHERSH TGDRPYQCEH SGCGKAFATG YGLKSHFRTH TGEKPYRCSE 
       310        320        330        340        350
DNCTKSFKTS GDLQKHIRTH TGERPFKCPI EGCGRSFTTS NIRKVHIRTH 
       360        370        380        390        400
TGERPYYCTE PGCGRAFASA TNYKNHVRIH TGEKPYVCTV PGCDKRFTEY 
       410        420        430        440        450
SSLYKHHVVH THSKPYNCNH CGKTYKQIST LAMHKRTAHN DTEPIEEEQE 
       460        470        480        490        500
AFFEPPPGQG DDVLKGSQIT YVTGVDGEDI VSTQVATVTQ SGLSQQVTLI 
       510        520        530        540        550
SQDGTQHVNI SQADMQAIGN TITMVTQDGT PITVPTHDAV ISSAGTHSVA 
       560        570        580        590        600
MVTAEGTEGQ QVAIVAQDLA AFHTASSEMG HQQHSHHLVT TETRPLTLVA 
       610        620        630 
TSNGTQIAVQ LGEQPSLEEA IRIASRIQQG ETPGLDD

Show »

Length:637

Mass (Da):69,038

Checksum:ⁱAF55892CDA7BD887

GO

Isoform 3 (identifier: O70230-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
97-125: TGDSLRLEDGQAVQLEDGTTAFIHHTSKD → N

« Hide

        10         20         30         40         50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL 
        60         70         80         90        100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSNSYD 
       110        120        130        140        150
QSSLQAVQLE DGTTAYIHHA VQVPQSDTIL AIQADGTVAG LHTGDATIDP 
       160        170        180        190        200
DTISALEQYA AKVSIDGSDG VTSTGMIGEN EQEKKMQIVL QGHATRVTPK 
       210        220        230        240        250
SQQSGEKAFR CKYDGCGKLY TTAHHLKVHE RSHTGDRPYQ CEHSGCGKAF 
       260        270        280        290        300
ATGYGLKSHF RTHTGEKPYR CSEDNCTKSF KTSGDLQKHI RTHTGERPFK 
       310        320        330        340        350
CPIEGCGRSF TTSNIRKVHI RTHTGERPYY CTEPGCGRAF ASATNYKNHV 
       360        370        380        390        400
RIHTGEKPYV CTVPGCDKRF TEYSSLYKHH VVHTHSKPYN CNHCGKTYKQ 
       410        420        430        440        450
ISTLAMHKRT AHNDTEPIEE EQEAFFEPPP GQGDDVLKGS QITYVTGVDG 
       460        470        480        490        500
EDIVSTQVAT VTQSGLSQQV TLISQDGTQH VNISQADMQA IGNTITMVTQ 
       510        520        530        540        550
DGTPITVPTH DAVISSAGTH SVAMVTAEGT EGQQVAIVAQ DLAAFHTASS 
       560        570        580        590        600
EMGHQQHSHH LVTTETRPLT LVATSNGTQI AVQLGEQPSL EEAIRIASRI 
       610
QQGETPGLDD

Show »

Length:610

Mass (Da):66,030

Checksum:ⁱ3E608E4FA31A3CDE

GO

Sequence cautionⁱ

The sequence AAC16899 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH37658 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAC25726 differs from that shown. Reason: Frameshift at position 5.Curated

The sequence BAC26281 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAC17144 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	190	K → T in BAC25726 (PubMed:16141072).Curated	1
Sequence conflictⁱ	250	T → K in BAC25726 (PubMed:16141072).Curated	1
Sequence conflictⁱ	261	H → D in BAC25726 (PubMed:16141072).Curated	1
Sequence conflictⁱ	342	N → T in BAC25726 (PubMed:16141072).Curated	1
Sequence conflictⁱ	508	H → N in BAC25726 (PubMed:16141072).Curated	1
Sequence conflictⁱ	528	Q → K in BAC25726 (PubMed:16141072).Curated	1
Sequence conflictⁱ	618	L → V in BAC25726 (PubMed:16141072).Curated	1
Sequence conflictⁱ	634	P → A in BAC25726 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_036979	97 – 125	TGDSL…HTSKD → N in isoform 3. 1 PublicationAdd BLAST		29
Alternative sequenceⁱVSP_036980	97 – 98	TG → R in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011758 mRNA Translation: AAC16899.1 Different initiation. AJ278435 Genomic DNA Translation: CAC17144.1 Different initiation. AK028056 mRNA Translation: BAC25726.1 Frameshift. AK029078 mRNA Translation: BAC26281.1 Different initiation. AK029926 mRNA Translation: BAC26682.1 BC037658 mRNA Translation: AAH37658.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS57580.1 [O70230-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_033307.2, NM_009281.3 [O70230-2] XP_006507595.1, XM_006507532.2 [O70230-1]
UniGeneⁱ	Mm.10815

Genome annotation databases

Ensemblⁱ	ENSMUST00000084727; ENSMUSP00000081778; ENSMUSG00000061079 [O70230-1] ENSMUST00000169638; ENSMUSP00000126015; ENSMUSG00000061079 [O70230-3] ENSMUST00000209505; ENSMUSP00000147673; ENSMUSG00000061079 [O70230-2] ENSMUST00000211798; ENSMUSP00000148235; ENSMUSG00000061079 [O70230-2]
GeneIDⁱ	20841
KEGGⁱ	mmu:20841
UCSC genome browser More...UCSCⁱ	uc009jew.1 mouse [O70230-2] uc009jex.1 mouse [O70230-1] uc012fse.1 mouse [O70230-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O70230	Zinc finger protein 143		HUMAN		638	UniRef90_P52747
Zinc finger protein 143		RAT		638
Uncharacterized protein		AOTNA		729
ZNF143 isoform 8 (Fragment)		PONAB		190
ZNF143 (Fragment)		CEREH		102
+358
O70230-3	Zinc finger protein 143		BOVIN		613	UniRef90_O70230-3
Uncharacterized protein		PANPA		611
Uncharacterized protein		CAVPO		611
Zinc finger protein 143		HUMAN		610
ZNF143 isoform 2		PANTR		610
+35

Protein	Similar proteins		Species	Score	Length	Source
O70230	Zinc finger protein 143		HUMAN		638	UniRef50_P52747
Zinc finger protein 143		RAT		638
Zinc finger protein 143		DANRE		623
Zinc finger protein 143		BOVIN		613
Zinc finger protein 143		XENLA		565
+749

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF011758 mRNA Translation: AAC16899.1 Different initiation. AJ278435 Genomic DNA Translation: CAC17144.1 Different initiation. AK028056 mRNA Translation: BAC25726.1 Frameshift. AK029078 mRNA Translation: BAC26281.1 Different initiation. AK029926 mRNA Translation: BAC26682.1 BC037658 mRNA Translation: AAH37658.1 Different initiation.
CCDSⁱ	CCDS57580.1 [O70230-2]
RefSeqⁱ	NP_033307.2, NM_009281.3 [O70230-2] XP_006507595.1, XM_006507532.2 [O70230-1]
UniGeneⁱ	Mm.10815

3D structure databases

ProteinModelPortalⁱ	O70230
SMRⁱ	O70230
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203516, 4 interactors
IntActⁱ	O70230, 3 interactors
STRINGⁱ	10090.ENSMUSP00000081778

PTM databases

iPTMnetⁱ	O70230
PhosphoSitePlusⁱ	O70230

Proteomic databases

EPDⁱ	O70230
MaxQBⁱ	O70230
PaxDbⁱ	O70230
PeptideAtlasⁱ	O70230
PRIDEⁱ	O70230

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000084727; ENSMUSP00000081778; ENSMUSG00000061079 [O70230-1] ENSMUST00000169638; ENSMUSP00000126015; ENSMUSG00000061079 [O70230-3] ENSMUST00000209505; ENSMUSP00000147673; ENSMUSG00000061079 [O70230-2] ENSMUST00000211798; ENSMUSP00000148235; ENSMUSG00000061079 [O70230-2]
GeneIDⁱ	20841
KEGGⁱ	mmu:20841
UCSCⁱ	uc009jew.1 mouse [O70230-2] uc009jex.1 mouse [O70230-1] uc012fse.1 mouse [O70230-3]

Organism-specific databases

CTDⁱ	20841
MGIⁱ	MGI:1277969 Zfp143

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144040
HOGENOMⁱ	HOG000118073
HOVERGENⁱ	HBG053078
InParanoidⁱ	O70230
KOⁱ	K20828
OMAⁱ	KMQIVLQ
OrthoDBⁱ	EOG091G0N38
PhylomeDBⁱ	O70230
TreeFamⁱ	TF333498

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6807505 RNA polymerase II transcribes snRNA genes R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Reactomeⁱ

R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O70230
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000061079 Expressed in 273 organ(s), highest expression level in embryo
CleanExⁱ	MM_ZFP143
Genevisibleⁱ	O70230 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN143_MOUSE
Accessionⁱ	O70230Primary (citable) accession number: O70230 Secondary accession number(s): Q8BGB0, Q8CEI6, Q8CI27
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
	Last sequence update:	May 5, 2009
	Last modified:	October 10, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O70230 (ZN143_MOUSE)

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Zinc finger protein 143

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ