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UniProtKB - O70230 (ZN143_MOUSE)
Protein
Zinc finger protein 143
Gene
Znf143
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 237 – 261 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 267 – 291 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 297 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 327 – 351 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 357 – 381 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 387 – 411 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 417 – 440 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- positive regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of snRNA transcription by RNA polymerase II Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 143Short name: Zfp-143 Alternative name(s): Selenocysteine tRNA gene transcription-activating factor Short name: mStaf |
Gene namesi | Name:Znf143 Synonyms:Staf, Zfp143 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1277969, Zfp143 |
VEuPathDBi | HostDB:ENSMUSG00000061079 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: MGI
- PcG protein complex Source: GO_Central
Other locations
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248071 | 1 – 638 | Zinc finger protein 143Add BLAST | 638 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Cross-linki | 213 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 352 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 406 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O70230 |
MaxQBi | O70230 |
PaxDbi | O70230 |
PeptideAtlasi | O70230 |
PRIDEi | O70230 |
ProteomicsDBi | 274999 [O70230-1] 275000 [O70230-2] 275001 [O70230-3] |
PTM databases
iPTMneti | O70230 |
PhosphoSitePlusi | O70230 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000061079, Expressed in embryo and 296 other tissues |
Genevisiblei | O70230, MM |
Interactioni
Subunit structurei
Interacts with CHD8.
By similarityBinary interactionsi
O70230
With | #Exp. | IntAct |
---|---|---|
Sall4 [Q8BX22] | 2 | EBI-5691478,EBI-2312582 |
Protein-protein interaction databases
BioGRIDi | 203516, 7 interactors |
IntActi | O70230, 4 interactors |
MINTi | O70230 |
STRINGi | 10090.ENSMUSP00000081778 |
Miscellaneous databases
RNActi | O70230, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 237 – 261 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 267 – 291 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 297 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 327 – 351 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 357 – 381 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 387 – 411 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 417 – 440 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157584 |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | O70230 |
OMAi | SEMGHQP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O70230 |
TreeFami | TF333498 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O70230-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL
60 70 80 90 100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSTGDS
110 120 130 140 150
LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS SLQAVQLEDG TTAYIHHAVQ
160 170 180 190 200
VPQSDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSDGVT
210 220 230 240 250
STGMIGENEQ EKKMQIVLQG HATRVTPKSQ QSGEKAFRCK YDGCGKLYTT
260 270 280 290 300
AHHLKVHERS HTGDRPYQCE HSGCGKAFAT GYGLKSHFRT HTGEKPYRCS
310 320 330 340 350
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP IEGCGRSFTT SNIRKVHIRT
360 370 380 390 400
HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE
410 420 430 440 450
YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ
460 470 480 490 500
EAFFEPPPGQ GDDVLKGSQI TYVTGVDGED IVSTQVATVT QSGLSQQVTL
510 520 530 540 550
ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPTHDA VISSAGTHSV
560 570 580 590 600
AMVTAEGTEG QQVAIVAQDL AAFHTASSEM GHQQHSHHLV TTETRPLTLV
610 620 630
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD
Sequence cautioni
The sequence AAC16899 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH37658 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC25726 differs from that shown. Reason: Frameshift.Curated
The sequence BAC26281 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC17144 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 190 | K → T in BAC25726 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 250 | T → K in BAC25726 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 261 | H → D in BAC25726 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 342 | N → T in BAC25726 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 508 | H → N in BAC25726 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 528 | Q → K in BAC25726 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 618 | L → V in BAC25726 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 634 | P → A in BAC25726 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036979 | 97 – 125 | TGDSL…HTSKD → N in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_036980 | 97 – 98 | TG → R in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF011758 mRNA Translation: AAC16899.1 Different initiation. AJ278435 Genomic DNA Translation: CAC17144.1 Different initiation. AK028056 mRNA Translation: BAC25726.1 Frameshift. AK029078 mRNA Translation: BAC26281.1 Different initiation. AK029926 mRNA Translation: BAC26682.1 BC037658 mRNA Translation: AAH37658.1 Different initiation. |
CCDSi | CCDS57580.1 [O70230-2] CCDS90307.1 [O70230-1] |
RefSeqi | NP_033307.2, NM_009281.3 [O70230-2] XP_006507595.1, XM_006507532.2 |
Genome annotation databases
Ensembli | ENSMUST00000084727; ENSMUSP00000081778; ENSMUSG00000061079 [O70230-1] ENSMUST00000169638; ENSMUSP00000126015; ENSMUSG00000061079 [O70230-3] ENSMUST00000209505; ENSMUSP00000147673; ENSMUSG00000061079 [O70230-2] ENSMUST00000211798; ENSMUSP00000148235; ENSMUSG00000061079 [O70230-2] |
GeneIDi | 20841 |
KEGGi | mmu:20841 |
UCSCi | uc009jew.1, mouse [O70230-2] uc009jex.1, mouse [O70230-1] uc012fse.1, mouse [O70230-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF011758 mRNA Translation: AAC16899.1 Different initiation. AJ278435 Genomic DNA Translation: CAC17144.1 Different initiation. AK028056 mRNA Translation: BAC25726.1 Frameshift. AK029078 mRNA Translation: BAC26281.1 Different initiation. AK029926 mRNA Translation: BAC26682.1 BC037658 mRNA Translation: AAH37658.1 Different initiation. |
CCDSi | CCDS57580.1 [O70230-2] CCDS90307.1 [O70230-1] |
RefSeqi | NP_033307.2, NM_009281.3 [O70230-2] XP_006507595.1, XM_006507532.2 |
3D structure databases
SMRi | O70230 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203516, 7 interactors |
IntActi | O70230, 4 interactors |
MINTi | O70230 |
STRINGi | 10090.ENSMUSP00000081778 |
PTM databases
iPTMneti | O70230 |
PhosphoSitePlusi | O70230 |
Proteomic databases
EPDi | O70230 |
MaxQBi | O70230 |
PaxDbi | O70230 |
PeptideAtlasi | O70230 |
PRIDEi | O70230 |
ProteomicsDBi | 274999 [O70230-1] 275000 [O70230-2] 275001 [O70230-3] |
Protocols and materials databases
Antibodypediai | 927, 86 antibodies from 24 providers |
DNASUi | 20841 |
Genome annotation databases
Ensembli | ENSMUST00000084727; ENSMUSP00000081778; ENSMUSG00000061079 [O70230-1] ENSMUST00000169638; ENSMUSP00000126015; ENSMUSG00000061079 [O70230-3] ENSMUST00000209505; ENSMUSP00000147673; ENSMUSG00000061079 [O70230-2] ENSMUST00000211798; ENSMUSP00000148235; ENSMUSG00000061079 [O70230-2] |
GeneIDi | 20841 |
KEGGi | mmu:20841 |
UCSCi | uc009jew.1, mouse [O70230-2] uc009jex.1, mouse [O70230-1] uc012fse.1, mouse [O70230-3] |
Organism-specific databases
CTDi | 20841 |
MGIi | MGI:1277969, Zfp143 |
VEuPathDBi | HostDB:ENSMUSG00000061079 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157584 |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | O70230 |
OMAi | SEMGHQP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O70230 |
TreeFami | TF333498 |
Miscellaneous databases
BioGRID-ORCSi | 20841, 2 hits in 64 CRISPR screens |
ChiTaRSi | Zfp143, mouse |
PROi | PR:O70230 |
RNActi | O70230, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000061079, Expressed in embryo and 296 other tissues |
Genevisiblei | O70230, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN143_MOUSE | |
Accessioni | O70230Primary (citable) accession number: O70230 Secondary accession number(s): Q8BGB0, Q8CEI6, Q8CI27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families