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Protein

Probable phospholipid-transporting ATPase IIA

Gene

Atp9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3914-aspartylphosphate intermediateBy similarity1
Metal bindingi785MagnesiumBy similarity1
Metal bindingi789MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IIA (EC:7.6.2.1)
Alternative name(s):
ATPase class II type 9A
Gene namesi
Name:Atp9a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1330826 Atp9a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 69CytoplasmicSequence analysisAdd BLAST68
Transmembranei70 – 91HelicalSequence analysisAdd BLAST22
Topological domaini92 – 96ExtracellularSequence analysis5
Transmembranei97 – 119HelicalSequence analysisAdd BLAST23
Topological domaini120 – 303CytoplasmicSequence analysisAdd BLAST184
Transmembranei304 – 325HelicalSequence analysisAdd BLAST22
Topological domaini326 – 332ExtracellularSequence analysis7
Transmembranei333 – 354HelicalSequence analysisAdd BLAST22
Topological domaini355 – 841CytoplasmicSequence analysisAdd BLAST487
Transmembranei842 – 862HelicalSequence analysisAdd BLAST21
Topological domaini863 – 874ExtracellularSequence analysisAdd BLAST12
Transmembranei875 – 893HelicalSequence analysisAdd BLAST19
Topological domaini894 – 923CytoplasmicSequence analysisAdd BLAST30
Transmembranei924 – 942HelicalSequence analysisAdd BLAST19
Topological domaini943 – 949ExtracellularSequence analysis7
Transmembranei950 – 972HelicalSequence analysisAdd BLAST23
Topological domaini973 – 978CytoplasmicSequence analysis6
Transmembranei979 – 999HelicalSequence analysisAdd BLAST21
Topological domaini1000 – 1006ExtracellularSequence analysis7
Transmembranei1007 – 1030HelicalSequence analysisAdd BLAST24
Topological domaini1031 – 1047CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000463762 – 1047Probable phospholipid-transporting ATPase IIAAdd BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO70228
PaxDbiO70228
PRIDEiO70228

PTM databases

iPTMnetiO70228
PhosphoSitePlusiO70228
SwissPalmiO70228

Expressioni

Tissue specificityi

Found in most tissues except spleen. Most abundant in brain. Also detected in fetal tissues.

Gene expression databases

BgeeiENSMUSG00000027546 Expressed in 294 organ(s), highest expression level in prefrontal cortex
CleanExiMM_ATP9A
ExpressionAtlasiO70228 baseline and differential
GenevisibleiO70228 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029060

Structurei

3D structure databases

ProteinModelPortaliO70228
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0210 Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00550000074723
HOGENOMiHOG000201571
HOVERGENiHBG050617
InParanoidiO70228
KOiK01530
PhylomeDBiO70228

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030356 ATP9A
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF49 PTHR24092:SF49, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O70228-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSIPLQPV RHKKRVDSRP RAGCCEWLRC CGGGEPRPRT VWLGHPEKRD
60 70 80 90 100
QRYPRNVINN QKYNFFTFLP GVLFSQFRYF FNFYFLLLAC SQFVPEMRLG
110 120 130 140 150
ALYTYWVPLG FVLAVTIIRE AVEEIRCYVR DKEMNSQVYS RLTSRGTVKV
160 170 180 190 200
KSSNIQVGDL ILVEKNQRVP ADMIFLRTSE KNGSCFLRTD QLDGETDWKL
210 220 230 240 250
RLPVACTQRL PTAADLLQIR SYVYAEEPNI DIHNFLGTFT REDSDPPISE
260 270 280 290 300
SLSIENTLWA GTVIASGTVV GVVLYTGREL RSVMNTSDPR SKIGLFDLEV
310 320 330 340 350
NCLTKILFGA LVVVSLVMVA LQHFAGRWYL QIIRFLLLFS NIIPISLRVN
360 370 380 390 400
LDMGKIVYSW VIRRDSKIPG TVVRSSTIPE QLGRISYLLT DKTGTLTQNE
410 420 430 440 450
MVFKRLHLGT VAYGLDSMDE VQSHIFSIYT QQSQDPPAQK GPTVTTKVRR
460 470 480 490 500
TMSSRVHEAV KAIALCHNVT PVYESNGVTD QAEAEKQFED SCRVYQASSP
510 520 530 540 550
DEVALVQWTE SVGLTLVGRD QSSMQLRTPG DQVLNLTILQ VFPFTYESKR
560 570 580 590 600
MGIIVRDEST GEITFYMKGA DVVMAGIVQY NDWLEEECGN MAREGLRVLV
610 620 630 640 650
VAKKSLTEEQ YQDFEARYVQ AKLSVHDRSL KVATVIESLE MEMELLCLTG
660 670 680 690 700
VEDQLQADVR PTLETLRNAG IKVWMLTGDK LETATCTAKN AHLVTRNQDI
710 720 730 740 750
HVFRLVTNRG EAHLELNAFR RKHDCALVIS GDSLEVCLKY YEYEFMELAC
760 770 780 790 800
QCPAVVCCRC APTQKAQIVR LLQERTGKLT CAVGDGGNDV SMIQESDCGV
810 820 830 840 850
GVEGKEGKQA SLAADFSITQ FKHLGRLLMV HGRNSYKRSA ALSQFVIHRS
860 870 880 890 900
LCISTMQAVF SSVFYFASVP LYQGFLIIGY STIYTMFPVF SLVLDKDVKS
910 920 930 940 950
EVAMLYPELY KDLLKGRPLS YKTFLIWVLI SIYQGSTIMY GALLLFESEF
960 970 980 990 1000
VHIVAISFTS LILTELLMVA LTIQTWHWLM TVAELLSLAC YIASLVFLHE
1010 1020 1030 1040
FIDVYFIATL SFLWKVSVIT LVSCLPLYVL KYLRRRFSPP SYSKLTS
Length:1,047
Mass (Da):118,609
Last modified:May 5, 2009 - v3
Checksum:i5CCFAB1A83A7B966
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AQC3A2AQC3_MOUSE
Phospholipid-transporting ATPase
Atp9a
1,105Annotation score:
Q8C288Q8C288_MOUSE
Phospholipid-transporting ATPase
Atp9a mCG_20648
1,031Annotation score:
Q8C4G3Q8C4G3_MOUSE
Phospholipid-transporting ATPase
Atp9a
1,029Annotation score:
A2AUZ0A2AUZ0_MOUSE
Probable phospholipid-transporting ...
Atp9a
112Annotation score:
A2AQC9A2AQC9_MOUSE
Probable phospholipid-transporting ...
Atp9a
189Annotation score:
A2AUZ1A2AUZ1_MOUSE
Probable phospholipid-transporting ...
Atp9a
88Annotation score:
B2FDH4B2FDH4_MOUSE
Probable phospholipid-transporting ...
Atp9a
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → K in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti129V → I in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti138V → I in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti227E → K in AAF08396 (PubMed:11015572).Curated1
Sequence conflicti227E → K in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti243D → N in AAF08396 (PubMed:11015572).Curated1
Sequence conflicti243D → N in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti278R → K in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti279E → K in AAF08396 (PubMed:11015572).Curated1
Sequence conflicti279E → K in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti432Q → P in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti475S → C in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti504 – 510ALVQWTE → TLAGKEG in AAH21814 (PubMed:15489334).Curated7
Sequence conflicti533V → I in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti613D → H in AAF08396 (PubMed:11015572).Curated1
Sequence conflicti742E → D in AAC05245 (PubMed:9548971).Curated1
Sequence conflicti784G → W in AAF08396 (PubMed:11015572).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152243 mRNA Translation: AAF08396.1
BC021814 mRNA Translation: AAH21814.1
BC006949 mRNA Translation: AAH06949.1
AF011336 mRNA Translation: AAC05245.1
CCDSiCCDS38345.1
PIRiT42229
RefSeqiNP_056546.2, NM_015731.3
UniGeneiMm.330819

Genome annotation databases

EnsembliENSMUST00000029060; ENSMUSP00000029060; ENSMUSG00000027546
ENSMUST00000178504; ENSMUSP00000136793; ENSMUSG00000027546
GeneIDi11981
KEGGimmu:11981
UCSCiuc008obc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152243 mRNA Translation: AAF08396.1
BC021814 mRNA Translation: AAH21814.1
BC006949 mRNA Translation: AAH06949.1
AF011336 mRNA Translation: AAC05245.1
CCDSiCCDS38345.1
PIRiT42229
RefSeqiNP_056546.2, NM_015731.3
UniGeneiMm.330819

3D structure databases

ProteinModelPortaliO70228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029060

PTM databases

iPTMnetiO70228
PhosphoSitePlusiO70228
SwissPalmiO70228

Proteomic databases

MaxQBiO70228
PaxDbiO70228
PRIDEiO70228

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029060; ENSMUSP00000029060; ENSMUSG00000027546
ENSMUST00000178504; ENSMUSP00000136793; ENSMUSG00000027546
GeneIDi11981
KEGGimmu:11981
UCSCiuc008obc.1 mouse

Organism-specific databases

CTDi10079
MGIiMGI:1330826 Atp9a

Phylogenomic databases

eggNOGiKOG0210 Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00550000074723
HOGENOMiHOG000201571
HOVERGENiHBG050617
InParanoidiO70228
KOiK01530
PhylomeDBiO70228

Enzyme and pathway databases

ReactomeiR-MMU-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiAtp9a mouse
PROiPR:O70228
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027546 Expressed in 294 organ(s), highest expression level in prefrontal cortex
CleanExiMM_ATP9A
ExpressionAtlasiO70228 baseline and differential
GenevisibleiO70228 MM

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030356 ATP9A
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF49 PTHR24092:SF49, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATP9A_MOUSE
AccessioniPrimary (citable) accession number: O70228
Secondary accession number(s): Q8VDI5, Q922L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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