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Protein

PDZ and LIM domain protein 3

Gene

Pdlim3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the organization of actin filament arrays within muscle cells.By similarity

GO - Molecular functioni

  • cytoskeletal protein binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • structural constituent of muscle Source: MGI

GO - Biological processi

  • actin filament organization Source: MGI
  • heart development Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 3
Alternative name(s):
Actinin-associated LIM protein
Alpha-actinin-2-associated LIM protein
Gene namesi
Name:Pdlim3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1859274 Pdlim3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758681 – 316PDZ and LIM domain protein 3Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1
Modified residuei164Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO70209
PaxDbiO70209
PeptideAtlasiO70209
PRIDEiO70209

2D gel databases

REPRODUCTION-2DPAGEiIPI00116347

PTM databases

iPTMnetiO70209
PhosphoSitePlusiO70209

Expressioni

Developmental stagei

At E15 highly expressed in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000031636 Expressed in 202 organ(s), highest expression level in urinary bladder
CleanExiMM_PDLIM3
ExpressionAtlasiO70209 baseline and differential
GenevisibleiO70209 MM

Interactioni

Subunit structurei

Interacts with ACTN2 (By similarity). Forms a heterodimer with PDLIM4 (via LIM domain) (PubMed:15663004).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO70209, 1 interactor
MINTiO70209
STRINGi10090.ENSMUSP00000034053

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO70209
SMRiO70209
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO70209

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84PDZPROSITE-ProRule annotationAdd BLAST84
Domaini244 – 303LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00590000082980
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiO70209
OrthoDBiEOG091G0A6C
PhylomeDBiO70209
TreeFamiTF106408

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR001478 PDZ
IPR036034 PDZ_sf
IPR006643 Zasp-like_motif
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SM00735 ZM, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQNVVLPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL
60 70 80 90 100
AIDGFGTESM THADAQDRIK AASYQLCLKI DRAETRLWSP QVSEDGKAHP
110 120 130 140 150
FKINLEAEPQ EFKPIGTAHN RRAQPFVAAA NIDDKRQVVS ASYNSPIGLY
160 170 180 190 200
STSNIQDALH GQLRGLIPGS LQNEPTASVP PQSDVYRMLH DNRDDPAAPR
210 220 230 240 250
QSGSFRVLQD LVNDGPDDRP AGTRSVRAPV TKVHGGAGSA QRMPLCDKCG
260 270 280 290 300
SGIVGAVVKA RDKYRHPECF VCADCNLNLK QKGYFFVEGE LYCETHARAR
310
TRPPEGYDTV TLYPKA
Length:316
Mass (Da):34,300
Last modified:August 1, 1998 - v1
Checksum:iE59916D0BC430B6F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSX6A0A1B0GSX6_MOUSE
PDZ and LIM domain 3, isoform CRA_a
Pdlim3 mCG_7019
364Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002283 mRNA Translation: AAC16673.1
AK078421 mRNA Translation: BAC37266.1
BC070418 mRNA Translation: AAH70418.1
CCDSiCCDS22281.1
RefSeqiNP_058078.1, NM_016798.3
UniGeneiMm.282900

Genome annotation databases

EnsembliENSMUST00000034053; ENSMUSP00000034053; ENSMUSG00000031636
GeneIDi53318
KEGGimmu:53318
UCSCiuc009lpl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002283 mRNA Translation: AAC16673.1
AK078421 mRNA Translation: BAC37266.1
BC070418 mRNA Translation: AAH70418.1
CCDSiCCDS22281.1
RefSeqiNP_058078.1, NM_016798.3
UniGeneiMm.282900

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5LNMR-A4-93[»]
1X64NMR-A226-301[»]
ProteinModelPortaliO70209
SMRiO70209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70209, 1 interactor
MINTiO70209
STRINGi10090.ENSMUSP00000034053

PTM databases

iPTMnetiO70209
PhosphoSitePlusiO70209

2D gel databases

REPRODUCTION-2DPAGEiIPI00116347

Proteomic databases

MaxQBiO70209
PaxDbiO70209
PeptideAtlasiO70209
PRIDEiO70209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034053; ENSMUSP00000034053; ENSMUSG00000031636
GeneIDi53318
KEGGimmu:53318
UCSCiuc009lpl.1 mouse

Organism-specific databases

CTDi27295
MGIiMGI:1859274 Pdlim3

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00590000082980
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiO70209
OrthoDBiEOG091G0A6C
PhylomeDBiO70209
TreeFamiTF106408

Miscellaneous databases

EvolutionaryTraceiO70209
PROiPR:O70209
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031636 Expressed in 202 organ(s), highest expression level in urinary bladder
CleanExiMM_PDLIM3
ExpressionAtlasiO70209 baseline and differential
GenevisibleiO70209 MM

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR001478 PDZ
IPR036034 PDZ_sf
IPR006643 Zasp-like_motif
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SM00735 ZM, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDLI3_MOUSE
AccessioniPrimary (citable) accession number: O70209
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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