Birc5

Functionⁱ

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	57	Zinc 1	1
Metal bindingⁱ	60	Zinc 1	1
Metal bindingⁱ	76	Zinc 2	1
Metal bindingⁱ	77	Zinc 1	1
Metal bindingⁱ	80	Zinc 2	1
Metal bindingⁱ	84	Zinc 1	1

GO - Molecular functionⁱ

chaperone binding Source: MGI
cofactor binding Source: UniProtKB
cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
enzyme binding Source: MGI
identical protein binding Source: MGI
microtubule binding Source: UniProtKB
protein heterodimerization activity Source: MGI
protein homodimerization activity Source: UniProtKB
Ran GTPase binding Source: MGI
tubulin binding Source: UniProtKB
zinc ion binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB
chromosome segregation Source: UniProtKB-KW
establishment of chromosome localization Source: UniProtKB
G2/M transition of mitotic cell cycle Source: UniProtKB
microtubule cytoskeleton organization
Source: MGI
Inferred from mutant phenotypeⁱ
- 11084331
mitotic cytokinesis Source: UniProtKB
mitotic spindle assembly checkpoint Source: UniProtKB
negative regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 12679106
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
negative regulation of neuron apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16049172
negative regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of cell cycle Source: MGI
positive regulation of exit from mitosis Source: UniProtKB
positive regulation of mitotic cell cycle Source: UniProtKB
protein-containing complex localization Source: UniProtKB
protein phosphorylation Source: UniProtKB
regulation of insulin secretion involved in cellular response to glucose stimulus
Source: MGI
Inferred from mutant phenotypeⁱ
- 19644667
regulation of mitotic cell cycle
Source: MGI
Inferred from mutant phenotypeⁱ
- 19644667
regulation of type B pancreatic cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 19644667

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Repressor, Thiol protease inhibitor
Biological process	Apoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-2467813 Separation of Sister Chromatids R-MMU-2500257 Resolution of Sister Chromatid Cohesion R-MMU-4615885 SUMOylation of DNA replication proteins R-MMU-5663220 RHO GTPases Activate Formins R-MMU-68877 Mitotic Prometaphase R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase
R-MMU-8951664 Neddylation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I32.005

MEROPSⁱ

I32.005

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Baculoviral IAP repeat-containing protein 5 Alternative name(s): Apoptosis inhibitor 4 Apoptosis inhibitor survivin TIAP
Gene namesⁱ	Name:Birc5 Synonyms:Api4, Iap4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1203517 Birc5

Keywords - Cellular componentⁱ

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000122357	1 – 140	Baculoviral IAP repeat-containing protein 5Add BLAST		140

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	23	N6-acetyllysineBy similarity	1
Modified residueⁱ	34	Phosphothreonine; by CDK1 and CDK151 Publication	1
Modified residueⁱ	48	PhosphothreonineBy similarity	1
Modified residueⁱ	90	N6-acetyllysineBy similarity	1
Modified residueⁱ	110	N6-acetyllysineBy similarity	1
Modified residueⁱ	112	N6-acetyllysineBy similarity	1
Modified residueⁱ	115	N6-acetyllysineBy similarity	1
Modified residueⁱ	117	Phosphothreonine; by AURKBBy similarity	1
Modified residueⁱ	129	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.By similarity

Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.By similarity

In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O70201
PaxDbⁱ	O70201
PeptideAtlas More...PeptideAtlasⁱ	O70201
PRIDEⁱ	O70201

PTM databases

iPTMnetⁱ	O70201
PhosphoSitePlusⁱ	O70201

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000017716 Expressed in 259 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_BIRC5
ExpressionAtlasⁱ	O70201 baseline and differential
Genevisibleⁱ	O70201 MM

Interactionⁱ

Subunit structureⁱ

Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce.By similarity

GO - Molecular functionⁱ

chaperone binding Source: MGI
enzyme binding Source: MGI
identical protein binding Source: MGI
microtubule binding Source: UniProtKB
protein heterodimerization activity Source: MGI
protein homodimerization activity Source: UniProtKB
Ran GTPase binding Source: MGI
tubulin binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198150, 2 interactors
ComplexPortalⁱ	CPX-113 Survivin homodimer complex CPX-119 Chromosomal passenger complex
STRINGⁱ	10090.ENSMUSP00000079124

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	11 – 13	Combined sources	3
Helixⁱ	15 – 20	Combined sources	6
Beta strandⁱ	29 – 31	Combined sources	3
Helixⁱ	35 – 40	Combined sources	6
Beta strandⁱ	43 – 45	Combined sources	3
Beta strandⁱ	55 – 57	Combined sources	3
Turnⁱ	58 – 60	Combined sources	3
Helixⁱ	73 – 79	Combined sources	7
Helixⁱ	85 – 88	Combined sources	4
Helixⁱ	93 – 95	Combined sources	3
Helixⁱ	98 – 116	Combined sources	19

Show more details

3D structure databases

ProteinModelPortalⁱ	O70201
SMRⁱ	O70201
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O70201

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	18 – 88	BIRAdd BLAST		71

Domainⁱ

The BIR repeat is necessary and sufficient for LAMTOR5 binding.By similarity

Sequence similaritiesⁱ

Belongs to the IAP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1101 Eukaryota ENOG410YPNM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047537
HOGENOMⁱ	HOG000008032
HOVERGENⁱ	HBG050690
InParanoidⁱ	O70201
KEGG Orthology (KO) More...KOⁱ	K08731
OMAⁱ	APQCEFV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T73
PhylomeDBⁱ	O70201
TreeFamⁱ	TF342652

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00022 BIR, 1 hit
InterProⁱ	View protein in InterPro IPR001370 BIR_rpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00653 BIR, 1 hit
SMARTⁱ	View protein in SMART SM00238 BIR, 1 hit
PROSITEⁱ	View protein in PROSITE PS50143 BIR_REPEAT_2, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O70201-1) [UniParc]FASTA Add to basket

Also known as: Survivin 140

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERMAE AGFIHCPTEN 
        60         70         80         90        100
EPDLAQCFFC FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQMEELTVSE 
       110        120        130        140
FLKLDRQRAK NKIAKETNNK QKEFEETAKT TRQSIEQLAA

Length:140

Mass (Da):16,298

Last modified:August 1, 1998 - v1

Checksum:ⁱ26F5ABF501A6D83C

GO

Isoform 2 (identifier: O70201-2) [UniParc]FASTA Add to basket

Also known as: Survivin 121

The sequence of this isoform differs from the canonical sequence as follows:
114-140: AKETNNKQKEFEETAKTTRQSIEQLAA → VCMIENKD

« Hide

        10         20         30         40         50
MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERMAE AGFIHCPTEN 
        60         70         80         90        100
EPDLAQCFFC FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQMEELTVSE 
       110        120 
FLKLDRQRAK NKIVCMIENK D

Show »

Length:121

Mass (Da):14,154

Checksum:ⁱ1E0EC7E01BA65585

GO

Isoform 3 (identifier: O70201-3) [UniParc]FASTA Add to basket

Also known as: Survivin 40

The sequence of this isoform differs from the canonical sequence as follows:
38-40: MAE → RGA
41-140: Missing.

« Hide

        10         20         30         40
MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERRGA

Show »

Length:40

Mass (Da):4,670

Checksum:ⁱFAD3C7E34A20518C

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002455	38 – 40	MAE → RGA in isoform 3. Curated	3
Alternative sequenceⁱVSP_002456	41 – 140	Missing in isoform 3. CuratedAdd BLAST	100
Alternative sequenceⁱVSP_002457	114 – 140	AKETN…EQLAA → VCMIENKD in isoform 2. 1 PublicationAdd BLAST	27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF077349 mRNA Translation: AAD34225.1 AB013819 mRNA Translation: BAA28266.1 AF115517 Genomic DNA Translation: AAD26199.1 AF115517 Genomic DNA Translation: AAD26200.1 AF115517 Genomic DNA Translation: AAD26201.1 BC004702 mRNA Translation: AAH04702.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25694.1 [O70201-1] CCDS25695.1 [O70201-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001012273.1, NM_001012273.1 [O70201-2] NP_033819.1, NM_009689.2 [O70201-1]
UniGeneⁱ	Mm.8552

Genome annotation databases

Ensemblⁱ	ENSMUST00000081387; ENSMUSP00000079124; ENSMUSG00000017716 [O70201-1] ENSMUST00000093906; ENSMUSP00000091433; ENSMUSG00000017716 [O70201-2]
GeneIDⁱ	11799
KEGGⁱ	mmu:11799
UCSC genome browser More...UCSCⁱ	uc007mod.1 mouse [O70201-1] uc007moe.1 mouse [O70201-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O70201	Baculoviral IAP repeat-containing 5 transcript variant 1		MOUSE		140	UniRef100_O70201

Protein	Similar proteins		Species	Score	Length	Source
O70201	Baculoviral IAP repeat-containing protein 5		RAT		142	UniRef90_O70201
Baculoviral IAP repeat-containing 5 transcript variant 1		MOUSE		140
UPI000A310C31		MUSPA		142
UPI000A316075		MUSCR		142
Baculoviral IAP repeat-containing 5, isoform CRA_b		RAT		142

Protein	Similar proteins		Species	Score	Length	Source
O70201	Baculoviral IAP repeat-containing protein 5		RAT		142	UniRef50_O70201
Baculoviral IAP repeat-containing protein 5		CAVPO		142
Baculoviral IAP repeat-containing 5 transcript variant 1		MOUSE		140
Baculoviral IAP repeat-containing protein 5		CRIGR		69
baculoviral IAP repeat-containing protein 5		DIPOR		142
+81
O70201-2	Survivin		HOLGL		143	UniRef50_O70201-2
Survivin		STIJA		151
baculoviral IAP repeat-containing protein 5		LINUN		145
Uncharacterized protein		STRPU		82
Uncharacterized protein		LOTGI		139
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF077349 mRNA Translation: AAD34225.1 AB013819 mRNA Translation: BAA28266.1 AF115517 Genomic DNA Translation: AAD26199.1 AF115517 Genomic DNA Translation: AAD26200.1 AF115517 Genomic DNA Translation: AAD26201.1 BC004702 mRNA Translation: AAH04702.1
CCDSⁱ	CCDS25694.1 [O70201-1] CCDS25695.1 [O70201-2]
RefSeqⁱ	NP_001012273.1, NM_001012273.1 [O70201-2] NP_033819.1, NM_009689.2 [O70201-1]
UniGeneⁱ	Mm.8552

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1M4M	X-ray	2.80	A	1-140	[»]
ProteinModelPortalⁱ	O70201
SMRⁱ	O70201
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198150, 2 interactors
ComplexPortalⁱ	CPX-113 Survivin homodimer complex CPX-119 Chromosomal passenger complex
STRINGⁱ	10090.ENSMUSP00000079124

Protein family/group databases

MEROPSⁱ	I32.005

MEROPSⁱ

I32.005

PTM databases

iPTMnetⁱ	O70201
PhosphoSitePlusⁱ	O70201

Proteomic databases

EPDⁱ	O70201
PaxDbⁱ	O70201
PeptideAtlasⁱ	O70201
PRIDEⁱ	O70201

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000081387; ENSMUSP00000079124; ENSMUSG00000017716 [O70201-1] ENSMUST00000093906; ENSMUSP00000091433; ENSMUSG00000017716 [O70201-2]
GeneIDⁱ	11799
KEGGⁱ	mmu:11799
UCSCⁱ	uc007mod.1 mouse [O70201-1] uc007moe.1 mouse [O70201-2]

Organism-specific databases

CTDⁱ	332
MGIⁱ	MGI:1203517 Birc5

Phylogenomic databases

eggNOGⁱ	KOG1101 Eukaryota ENOG410YPNM LUCA
GeneTreeⁱ	ENSGT00510000047537
HOGENOMⁱ	HOG000008032
HOVERGENⁱ	HBG050690
InParanoidⁱ	O70201
KOⁱ	K08731
OMAⁱ	APQCEFV
OrthoDBⁱ	EOG091G0T73
PhylomeDBⁱ	O70201
TreeFamⁱ	TF342652

Enzyme and pathway databases

Reactomeⁱ	R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-2467813 Separation of Sister Chromatids R-MMU-2500257 Resolution of Sister Chromatid Cohesion R-MMU-4615885 SUMOylation of DNA replication proteins R-MMU-5663220 RHO GTPases Activate Formins R-MMU-68877 Mitotic Prometaphase R-MMU-8951664 Neddylation

Reactomeⁱ

R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-4615885 SUMOylation of DNA replication proteins
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase
R-MMU-8951664 Neddylation

Miscellaneous databases

EvolutionaryTraceⁱ	O70201
Protein Ontology More...PROⁱ	PR:O70201
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017716 Expressed in 259 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_BIRC5
ExpressionAtlasⁱ	O70201 baseline and differential
Genevisibleⁱ	O70201 MM

Family and domain databases

CDDⁱ	cd00022 BIR, 1 hit
InterProⁱ	View protein in InterPro IPR001370 BIR_rpt
Pfamⁱ	View protein in Pfam PF00653 BIR, 1 hit
SMARTⁱ	View protein in SMART SM00238 BIR, 1 hit
PROSITEⁱ	View protein in PROSITE PS50143 BIR_REPEAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BIRC5_MOUSE
Accessionⁱ	O70201Primary (citable) accession number: O70201 Secondary accession number(s): Q923F7, Q9WU53, Q9WU54
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	August 1, 1998
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O70201 (BIRC5_MOUSE)

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Baculoviral IAP repeat-containing protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ