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Protein

Allograft inflammatory factor 1

Gene

Aif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi58 – 691PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1052Add BLAST12

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1
Short name:
AIF-1
Alternative name(s):
Ionized calcium-binding adapter molecule 1
Gene namesi
Name:Aif1
Synonyms:Iba1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1343098 Aif1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000738672 – 147Allograft inflammatory factor 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei11N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70200
PRIDEiO70200

PTM databases

iPTMnetiO70200
PhosphoSitePlusiO70200

Expressioni

Tissue specificityi

Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000024397 Expressed in 150 organ(s), highest expression level in testis
CleanExiMM_AIF1
ExpressionAtlasiO70200 baseline and differential
GenevisibleiO70200 MM

Interactioni

Subunit structurei

Homodimer (Potential). Monomer. Interacts with LCP1.Curated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198041, 2 interactors
STRINGi10090.ENSMUSP00000025257

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO70200
SMRiO70200
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO70200

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 115EF-hand 2; degeneratePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCUI Eukaryota
ENOG411206J LUCA
GeneTreeiENSGT00390000013846
HOGENOMiHOG000231928
HOVERGENiHBG004002
InParanoidiO70200
KOiK18617
OMAiDDPKYST
OrthoDBiEOG091G0ZI9
PhylomeDBiO70200
TreeFamiTF320736

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQSRDLQGG KAFGLLKAQQ EERLEGINKQ FLDDPKYSND EDLPSKLEAF
60 70 80 90 100
KVKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKRLI REVSSGSEET
110 120 130 140
FSYSDFLRMM LGKRSAILRM ILMYEEKNKE HKRPTGPPAK KAISELP
Length:147
Mass (Da):16,911
Last modified:August 1, 1998 - v1
Checksum:iD8974825C153D3CA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYJ2G3UYJ2_MOUSE
Allograft inflammatory factor 1
Aif1
128Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013745 mRNA Translation: BAA28216.1
AB036423 Genomic DNA Translation: BAB20758.1
D86382 mRNA Translation: BAA86387.1
AF074959 mRNA Translation: AAC25604.1
U82792 Genomic DNA Translation: AAC24189.1
AK006184 mRNA Translation: BAB24445.1
AK006562 mRNA Translation: BAB24654.1
AF109719 Genomic DNA Translation: AAC82481.1
BC021539 mRNA Translation: AAH21539.1
CCDSiCCDS28689.1
RefSeqiNP_062340.1, NM_019467.2
XP_006523566.1, XM_006523503.3
XP_006523567.1, XM_006523504.3
UniGeneiMm.10747

Genome annotation databases

EnsembliENSMUST00000025257; ENSMUSP00000025257; ENSMUSG00000024397
ENSMUST00000172693; ENSMUSP00000134214; ENSMUSG00000024397
ENSMUST00000173324; ENSMUSP00000133709; ENSMUSG00000024397
GeneIDi11629
KEGGimmu:11629
UCSCiuc008cgl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013745 mRNA Translation: BAA28216.1
AB036423 Genomic DNA Translation: BAB20758.1
D86382 mRNA Translation: BAA86387.1
AF074959 mRNA Translation: AAC25604.1
U82792 Genomic DNA Translation: AAC24189.1
AK006184 mRNA Translation: BAB24445.1
AK006562 mRNA Translation: BAB24654.1
AF109719 Genomic DNA Translation: AAC82481.1
BC021539 mRNA Translation: AAH21539.1
CCDSiCCDS28689.1
RefSeqiNP_062340.1, NM_019467.2
XP_006523566.1, XM_006523503.3
XP_006523567.1, XM_006523504.3
UniGeneiMm.10747

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WY9X-ray2.10A1-147[»]
ProteinModelPortaliO70200
SMRiO70200
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198041, 2 interactors
STRINGi10090.ENSMUSP00000025257

PTM databases

iPTMnetiO70200
PhosphoSitePlusiO70200

Proteomic databases

PaxDbiO70200
PRIDEiO70200

Protocols and materials databases

DNASUi11629
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025257; ENSMUSP00000025257; ENSMUSG00000024397
ENSMUST00000172693; ENSMUSP00000134214; ENSMUSG00000024397
ENSMUST00000173324; ENSMUSP00000133709; ENSMUSG00000024397
GeneIDi11629
KEGGimmu:11629
UCSCiuc008cgl.1 mouse

Organism-specific databases

CTDi199
MGIiMGI:1343098 Aif1

Phylogenomic databases

eggNOGiENOG410KCUI Eukaryota
ENOG411206J LUCA
GeneTreeiENSGT00390000013846
HOGENOMiHOG000231928
HOVERGENiHBG004002
InParanoidiO70200
KOiK18617
OMAiDDPKYST
OrthoDBiEOG091G0ZI9
PhylomeDBiO70200
TreeFamiTF320736

Miscellaneous databases

EvolutionaryTraceiO70200
PROiPR:O70200
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024397 Expressed in 150 organ(s), highest expression level in testis
CleanExiMM_AIF1
ExpressionAtlasiO70200 baseline and differential
GenevisibleiO70200 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAIF1_MOUSE
AccessioniPrimary (citable) accession number: O70200
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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