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UniProtKB - O70173 (P3C2G_RAT)
Protein
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
Gene
Pik3c2g
Organism
Rattus norvegicus (Rat)
Status
Functioni
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (PubMed:9516481).
May play a role in SDF1A-stimulated chemotaxis (By similarity).
By similarity1 PublicationCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H+1 PublicationEC:2.7.1.1371 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H+1 PublicationEC:2.7.1.1541 PublicationThis reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase activity Source: UniProtKB
- 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RGD
- ATP binding Source: UniProtKB-KW
- phosphatidylinositol binding Source: InterPro
- phosphatidylinositol kinase activity Source: GO_Central
GO - Biological processi
- cell migration Source: GO_Central
- chemotaxis Source: RGD
- phosphatidylinositol 3-kinase signaling Source: GO_Central
- phosphatidylinositol-3-phosphate biosynthetic process Source: UniProtKB
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol phosphate biosynthetic process Source: GO_Central
- viral RNA genome replication Source: RGD
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Chemotaxis, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.137, 5301 2.7.1.154, 5301 |
Reactomei | R-RNO-1660499, Synthesis of PIPs at the plasma membrane R-RNO-1660514, Synthesis of PIPs at the Golgi membrane |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Pik3c2g |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620231, Pik3c2g |
Subcellular locationi
Other locations
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus Source: RGD
Nucleus
- nuclear envelope Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: GO_Central
- extrinsic component of membrane Source: RGD
- membrane Source: GO_Central
- phosphatidylinositol 3-kinase complex Source: GO_Central
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088801 | 1 – 1505 | Phosphatidylinositol 3-kinase C2 domain-containing subunit gammaAdd BLAST | 1505 |
Proteomic databases
PaxDbi | O70173 |
PRIDEi | O70173 |
PTM databases
PhosphoSitePlusi | O70173 |
Expressioni
Tissue specificityi
Predominantly expressed in normal liver. High levels also found in regenerating liver. Very low levels found in heart and testis.1 Publication
Developmental stagei
Higher levels of expression found in adult liver than in fetal liver.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 278 – 370 | PI3K-RBDPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 540 – 688 | C2 PI3K-typePROSITE-ProRule annotationAdd BLAST | 149 | |
Domaini | 703 – 879 | PIK helicalPROSITE-ProRule annotationAdd BLAST | 177 | |
Domaini | 948 – 1226 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 279 | |
Domaini | 1259 – 1371 | PXPROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 1384 – 1505 | C2PROSITE-ProRule annotationAdd BLAST | 122 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 954 – 960 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 1090 – 1098 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 1109 – 1135 | Activation loopPROSITE-ProRule annotationAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 32 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0905, Eukaryota |
InParanoidi | O70173 |
PhylomeDBi | O70173 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit 2.60.40.150, 2 hits 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000008, C2_dom IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR002420, PI3K-type_C2_dom IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR000341, PI3K_Ras-bd_dom IPR015433, PI_Kinase IPR001683, PX_dom IPR036871, PX_dom_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF00792, PI3K_C2, 1 hit PF00794, PI3K_rbd, 1 hit PF00613, PI3Ka, 1 hit PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 2 hits SM00142, PI3K_C2, 1 hit SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit SM00312, PX, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49562, SSF49562, 2 hits SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS51547, C2_PI3K, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51546, PI3K_RBD, 1 hit PS51545, PIK_HELICAL, 1 hit PS50195, PX, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O70173-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYNWQTEPN RAEPQEGGHD HQQCHHADQH LSSRQVRLGF DQLVEELSNK
60 70 80 90 100
TPLPEDEKEG TCFVPDTPNL DSKWQSIYGP HPRHFNEFTS QSPHFSQLPF
110 120 130 140 150
GKASAIGFNP AVLPAHQFIH EGASWRNPTR KYHGGEDPRF SALTPSSTGL
160 170 180 190 200
DKCHQQGQSG TEHCNYYVEP ENNVPHHYSP YSMDSIPDSE EKGSGDADLV
210 220 230 240 250
EPSLVFSKDS FLPRASENMS VESTEPIGCP LEIVEAPQGS NKSLASFCNN
260 270 280 290 300
VTKIRGLYHA SDTNSNSGKI WAITTAYPSR LFADTQFRVK ISTDNSAQLL
310 320 330 340 350
LLKPPANYLV KDLIAEILLL CANEQLSPKE YLLSICGSEE FLQTDHCLGS
360 370 380 390 400
HKIFQKSKSV IQLHLQRSRD TPGKLSRKRD DDRSRVHLNQ LLEFTHIWKI
410 420 430 440 450
SRQCLSTVMK SYNLHVEHLL KTQEDVEEKP LSSMFSCGRH PPQPHGNDII
460 470 480 490 500
EDVRNICSVL GCIETKQVSD AVKELTLILQ RPSQNFHQNS ETSKKGFIEN
510 520 530 540 550
VTSELSRSLH QLVDVYCSSF CTDFRPARAP GGVSRDHAGL HSHLSFTVCS
560 570 580 590 600
LHNVPETWAH SYKAFSFSCW LTYAGKKLCQ VKSCRSLPVT KSFSFSVNWN
610 620 630 640 650
EIINFPLEIK SLPRESMLVI KLFGIDSATH SANLLAWTCL PLFPKEKSPL
660 670 680 690 700
GSRLLSMTLQ SEPPIEMMAP GVWDGSQPTP LTLQIDFPAA TWEYVKPETE
710 720 730 740 750
ENRTDHQEPP RECLKHIARL SQKQPPLLLS VEKRRYLWFY RFYCNNENSS
760 770 780 790 800
LPLVLGSAPG WDEGTVSEMH AVLRRWTFSH PLEALGLLTS RFPDQDIREV
810 820 830 840 850
AVQQLDNFLT DELLDCLPQL VQAVKFEWSL ESPLVELLLH RSLQSIRVAH
860 870 880 890 900
RLFWLLRDAQ GEDYFKSWYQ ELLAALQFCA GEALIEELSK EQKLVKLLGD
910 920 930 940 950
IGEKVKSAGD AQRKDVLKKE IGSLEEFFKD IKTCHLPLNP ALCVKGIDRD
960 970 980 990 1000
ACSYFTSNAL PLKITFINAN PMGKNISVIF KAGDDLRQDM LVLQIIQVMD
1010 1020 1030 1040 1050
NVWLQEGLDM QMIIYGCLAT GKAQGFIEMV PDAVTLAKIH LHSGLIGPLK
1060 1070 1080 1090 1100
ENTIKKWFSQ HNHLKEDYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM
1110 1120 1130 1140 1150
LTKSGHMFHI DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNTQ
1160 1170 1180 1190 1200
HFQDFVELCC RAYNIVRKHS QLLLSLLEMM LHAGLPELRG IEDLKYVHDN
1210 1220 1230 1240 1250
LRPQDTDLEA TSHFTTKIKQ SLECFPVKLN NLIHTLAQMP AFSLARPAPQ
1260 1270 1280 1290 1300
TPPQECCVLN KTRTIQRVTI LGFSKTHSNL YLIEVTRSDN RKNLAKKSFE
1310 1320 1330 1340 1350
QFYRLHSQIQ KQFPLLTLPE FPHWWHLPFT DSHHERIRDL SHYVEQVLHG
1360 1370 1380 1390 1400
SYEVANSDCV LSFFLSEHIQ QTLEDSPFVD PGDHSPDKSP QVQLLMTYED
1410 1420 1430 1440 1450
TKLTILVKHL KNIHLPDGSA PSAHVEIYLL PHPSEVRRKK TKCVPKCTDP
1460 1470 1480 1490 1500
TYNEIVVYDD VSGLQGHVLM LIVKSKTVFV GAVNIQLCSV PLNEEKWYPL
GNSII
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3ZE56 | D3ZE56_RAT | Phosphatidylinositol 3-kinase C2 do... | Pik3c2g | 1,505 | Annotation score: | ||
A0A0G2JZP4 | A0A0G2JZP4_RAT | RNA-directed DNA polymerase | Pik3c2g | 1,078 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009636 mRNA Translation: BAA25634.1 |
RefSeqi | NP_446375.1, NM_053923.1 |
Genome annotation databases
GeneIDi | 116720 |
KEGGi | rno:116720 |
UCSCi | RGD:620231, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009636 mRNA Translation: BAA25634.1 |
RefSeqi | NP_446375.1, NM_053923.1 |
3D structure databases
AlphaFoldDBi | O70173 |
SMRi | O70173 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000043855 |
PTM databases
PhosphoSitePlusi | O70173 |
Proteomic databases
PaxDbi | O70173 |
PRIDEi | O70173 |
Genome annotation databases
GeneIDi | 116720 |
KEGGi | rno:116720 |
UCSCi | RGD:620231, rat |
Organism-specific databases
CTDi | 5288 |
RGDi | 620231, Pik3c2g |
Phylogenomic databases
eggNOGi | KOG0905, Eukaryota |
InParanoidi | O70173 |
PhylomeDBi | O70173 |
Enzyme and pathway databases
BRENDAi | 2.7.1.137, 5301 2.7.1.154, 5301 |
Reactomei | R-RNO-1660499, Synthesis of PIPs at the plasma membrane R-RNO-1660514, Synthesis of PIPs at the Golgi membrane |
Miscellaneous databases
PROi | PR:O70173 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit 2.60.40.150, 2 hits 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000008, C2_dom IPR035892, C2_domain_sf IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR002420, PI3K-type_C2_dom IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR000341, PI3K_Ras-bd_dom IPR015433, PI_Kinase IPR001683, PX_dom IPR036871, PX_dom_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00454, PI3_PI4_kinase, 1 hit PF00792, PI3K_C2, 1 hit PF00794, PI3K_rbd, 1 hit PF00613, PI3Ka, 1 hit PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 2 hits SM00142, PI3K_C2, 1 hit SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit SM00312, PX, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF49562, SSF49562, 2 hits SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS51547, C2_PI3K, 1 hit PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51546, PI3K_RBD, 1 hit PS51545, PIK_HELICAL, 1 hit PS50195, PX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P3C2G_RAT | |
Accessioni | O70173Primary (citable) accession number: O70173 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families