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UniProtKB - O70173 (P3C2G_RAT)

Entry version 157 (25 May 2022)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
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Protein

Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Gene

Pik3c2g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (PubMed:9516481).

May play a role in SDF1A-stimulated chemotaxis (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processChemotaxis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.137, 5301
2.7.1.154, 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-1660499, Synthesis of PIPs at the plasma membrane
R-RNO-1660514, Synthesis of PIPs at the Golgi membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma1 Publication (EC:2.7.1.1371 Publication, EC:2.7.1.1541 Publication)
Short name:
PI3K-C2-gamma
Short name:
PtdIns-3-kinase C2 subunit gamma
Alternative name(s):
Phosphoinositide 3-kinase-C2-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pik3c2g
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		620231, Pik3c2g

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888011 – 1505Phosphatidylinositol 3-kinase C2 domain-containing subunit gammaAdd BLAST1505

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O70173

PRoteomics IDEntifications database

More...PRIDEi		O70173

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O70173

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in normal liver. High levels also found in regenerating liver. Very low levels found in heart and testis.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Higher levels of expression found in adult liver than in fetal liver.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000043855

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O70173

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O70173

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini278 – 370PI3K-RBDPROSITE-ProRule annotationAdd BLAST93
Domaini540 – 688C2 PI3K-typePROSITE-ProRule annotationAdd BLAST149
Domaini703 – 879PIK helicalPROSITE-ProRule annotationAdd BLAST177
Domaini948 – 1226PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST279
Domaini1259 – 1371PXPROSITE-ProRule annotationAdd BLAST113
Domaini1384 – 1505C2PROSITE-ProRule annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni954 – 960G-loopPROSITE-ProRule annotation7
Regioni1090 – 1098Catalytic loopPROSITE-ProRule annotation9
Regioni1109 – 1135Activation loopPROSITE-ProRule annotationAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 32Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0905, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O70173

Database for complete collections of gene phylogenies

More...PhylomeDBi		O70173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR002420, PI3K-type_C2_dom
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR000341, PI3K_Ras-bd_dom
IPR015433, PI_Kinase
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit
PF00787, PX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits
SM00142, PI3K_C2, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SM00312, PX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF49562, SSF49562, 2 hits
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS51547, C2_PI3K, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit
PS50195, PX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYNWQTEPN RAEPQEGGHD HQQCHHADQH LSSRQVRLGF DQLVEELSNK 
        60         70         80         90        100
TPLPEDEKEG TCFVPDTPNL DSKWQSIYGP HPRHFNEFTS QSPHFSQLPF 
       110        120        130        140        150
GKASAIGFNP AVLPAHQFIH EGASWRNPTR KYHGGEDPRF SALTPSSTGL 
       160        170        180        190        200
DKCHQQGQSG TEHCNYYVEP ENNVPHHYSP YSMDSIPDSE EKGSGDADLV 
       210        220        230        240        250
EPSLVFSKDS FLPRASENMS VESTEPIGCP LEIVEAPQGS NKSLASFCNN 
       260        270        280        290        300
VTKIRGLYHA SDTNSNSGKI WAITTAYPSR LFADTQFRVK ISTDNSAQLL 
       310        320        330        340        350
LLKPPANYLV KDLIAEILLL CANEQLSPKE YLLSICGSEE FLQTDHCLGS 
       360        370        380        390        400
HKIFQKSKSV IQLHLQRSRD TPGKLSRKRD DDRSRVHLNQ LLEFTHIWKI 
       410        420        430        440        450
SRQCLSTVMK SYNLHVEHLL KTQEDVEEKP LSSMFSCGRH PPQPHGNDII 
       460        470        480        490        500
EDVRNICSVL GCIETKQVSD AVKELTLILQ RPSQNFHQNS ETSKKGFIEN 
       510        520        530        540        550
VTSELSRSLH QLVDVYCSSF CTDFRPARAP GGVSRDHAGL HSHLSFTVCS 
       560        570        580        590        600
LHNVPETWAH SYKAFSFSCW LTYAGKKLCQ VKSCRSLPVT KSFSFSVNWN 
       610        620        630        640        650
EIINFPLEIK SLPRESMLVI KLFGIDSATH SANLLAWTCL PLFPKEKSPL 
       660        670        680        690        700
GSRLLSMTLQ SEPPIEMMAP GVWDGSQPTP LTLQIDFPAA TWEYVKPETE 
       710        720        730        740        750
ENRTDHQEPP RECLKHIARL SQKQPPLLLS VEKRRYLWFY RFYCNNENSS 
       760        770        780        790        800
LPLVLGSAPG WDEGTVSEMH AVLRRWTFSH PLEALGLLTS RFPDQDIREV 
       810        820        830        840        850
AVQQLDNFLT DELLDCLPQL VQAVKFEWSL ESPLVELLLH RSLQSIRVAH 
       860        870        880        890        900
RLFWLLRDAQ GEDYFKSWYQ ELLAALQFCA GEALIEELSK EQKLVKLLGD 
       910        920        930        940        950
IGEKVKSAGD AQRKDVLKKE IGSLEEFFKD IKTCHLPLNP ALCVKGIDRD 
       960        970        980        990       1000
ACSYFTSNAL PLKITFINAN PMGKNISVIF KAGDDLRQDM LVLQIIQVMD 
      1010       1020       1030       1040       1050
NVWLQEGLDM QMIIYGCLAT GKAQGFIEMV PDAVTLAKIH LHSGLIGPLK 
      1060       1070       1080       1090       1100
ENTIKKWFSQ HNHLKEDYEK ALRNFFYSCA GWCVVTFILG VCDRHNDNIM 
      1110       1120       1130       1140       1150
LTKSGHMFHI DFGKFLGHAQ TFGGIKRDRA PFIFTSEMEY FITEGGKNTQ 
      1160       1170       1180       1190       1200
HFQDFVELCC RAYNIVRKHS QLLLSLLEMM LHAGLPELRG IEDLKYVHDN 
      1210       1220       1230       1240       1250
LRPQDTDLEA TSHFTTKIKQ SLECFPVKLN NLIHTLAQMP AFSLARPAPQ 
      1260       1270       1280       1290       1300
TPPQECCVLN KTRTIQRVTI LGFSKTHSNL YLIEVTRSDN RKNLAKKSFE 
      1310       1320       1330       1340       1350
QFYRLHSQIQ KQFPLLTLPE FPHWWHLPFT DSHHERIRDL SHYVEQVLHG 
      1360       1370       1380       1390       1400
SYEVANSDCV LSFFLSEHIQ QTLEDSPFVD PGDHSPDKSP QVQLLMTYED 
      1410       1420       1430       1440       1450
TKLTILVKHL KNIHLPDGSA PSAHVEIYLL PHPSEVRRKK TKCVPKCTDP 
      1460       1470       1480       1490       1500
TYNEIVVYDD VSGLQGHVLM LIVKSKTVFV GAVNIQLCSV PLNEEKWYPL 

GNSII
Length:1,505
Mass (Da):170,975
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5ED4C2239968C4B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZE56D3ZE56_RAT
Phosphatidylinositol 3-kinase C2 do...
Pik3c2g
1,505Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JZP4A0A0G2JZP4_RAT
RNA-directed DNA polymerase
Pik3c2g
1,078Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB009636 mRNA Translation: BAA25634.1

NCBI Reference Sequences

More...RefSeqi		NP_446375.1, NM_053923.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:116720

UCSC genome browser

More...UCSCi		RGD:620231, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009636 mRNA Translation: BAA25634.1
RefSeqiNP_446375.1, NM_053923.1

3D structure databases

AlphaFoldDBiO70173
SMRiO70173
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043855

PTM databases

PhosphoSitePlusiO70173

Proteomic databases

PaxDbiO70173
PRIDEiO70173

Genome annotation databases

GeneIDi116720
KEGGirno:116720
UCSCiRGD:620231, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5288
RGDi620231, Pik3c2g

Phylogenomic databases

eggNOGiKOG0905, Eukaryota
InParanoidiO70173
PhylomeDBiO70173

Enzyme and pathway databases

BRENDAi2.7.1.137, 5301
2.7.1.154, 5301
ReactomeiR-RNO-1660499, Synthesis of PIPs at the plasma membrane
R-RNO-1660514, Synthesis of PIPs at the Golgi membrane

Miscellaneous databases

Protein Ontology

More...PROi		PR:O70173

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 2 hits
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR002420, PI3K-type_C2_dom
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR000341, PI3K_Ras-bd_dom
IPR015433, PI_Kinase
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit
PF00787, PX, 1 hit
SMARTiView protein in SMART
SM00239, C2, 2 hits
SM00142, PI3K_C2, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SM00312, PX, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF49562, SSF49562, 2 hits
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51547, C2_PI3K, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit
PS50195, PX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP3C2G_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O70173
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: May 25, 2022
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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