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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Gene

Pip4k2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity). May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size.By similarity1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • megakaryocyte development Source: UniProtKB
  • positive regulation of autophagosome assembly Source: MGI
  • regulation of autophagy Source: MGI

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-6811555 PI5P Regulates TP53 Acetylation
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847453 Synthesis of PIPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC:2.7.1.149)
Alternative name(s):
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
Diphosphoinositide kinase 2-alpha
Phosphatidylinositol 5-phosphate 4-kinase type II alpha
Short name:
PI(5)P 4-kinase type II alpha
Short name:
PIP4KII-alpha
PtdIns(5)P-4-kinase isoform 2-alpha
Gene namesi
Name:Pip4k2a
Synonyms:Pip5k2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1298206 Pip4k2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001854662 – 405Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphothreonineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei89N6-acetyllysineBy similarity1
Modified residuei145N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70172
PaxDbiO70172
PeptideAtlasiO70172
PRIDEiO70172

PTM databases

iPTMnetiO70172
PhosphoSitePlusiO70172

Expressioni

Tissue specificityi

Detected in rod photoreceptor cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000026737 Expressed in 312 organ(s), highest expression level in ventral horn of spinal cord
ExpressionAtlasiO70172 baseline and differential
GenevisibleiO70172 MM

Interactioni

Subunit structurei

Homodimer. Interacts with PIP4K2B. Interaction with PIP4K2B may modulate localization to the nucleus (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-49438N
IntActiO70172, 7 interactors
MINTiO70172
STRINGi10090.ENSMUSP00000006912

Structurei

3D structure databases

ProteinModelPortaliO70172
SMRiO70172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 405PIPKPROSITE-ProRule annotationAdd BLAST373

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiO70172
KOiK00920
OMAiANDSQAR
OrthoDBiEOG091G0857
PhylomeDBiO70172
TreeFamiTF354315

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 1 hit
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70172-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPGNLGSS VLASKTKTKK KHFVAQKVKL FRASDPLLSV LMWGVNHSIN
60 70 80 90 100
ELSHVQIPVM LMPDDFKAYS KIKVDNHLFN KENMPSHFKF KEYCPMVFRN
110 120 130 140 150
LRERFGIDDQ DFQNSLTRSA PLPNDSQARS GARFHTSYDK RYVIKTITSE
160 170 180 190 200
DVAEMHNILK KYHQYIVECH GVTLLPQFLG MYRLNVDGVE IYVIVTRNVF
210 220 230 240 250
SHRLSVYRKY DLKGSTVARE ASDKEKAKEL PTLKDNDFIN EGQKIYIDDN
260 270 280 290 300
NKKIFLEKLK KDVEFLAQLK LMDYSLLVGI HDVERAEQEE VECEENDGEE
310 320 330 340 350
EGESDSTHPI GTPPDSPGNT LNSSPPLAPG EFDPNIDVYA IKCHENAPRK
360 370 380 390 400
EVYFMAIIDI LTHYDAKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFLDF

IGHIL
Length:405
Mass (Da):46,152
Last modified:August 1, 1998 - v1
Checksum:i2D6CC431BDA4D967
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RJE8F6RJE8_MOUSE
Phosphatidylinositol 5-phosphate 4-...
Pip4k2a
214Annotation score:
A2ASS3A2ASS3_MOUSE
Phosphatidylinositol 5-phosphate 4-...
Pip4k2a
83Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009615 mRNA Translation: BAA25676.1
BC011097 mRNA Translation: AAH11097.1
CCDSiCCDS15712.1
RefSeqiNP_032871.3, NM_008845.4
UniGeneiMm.313977

Genome annotation databases

EnsembliENSMUST00000006912; ENSMUSP00000006912; ENSMUSG00000026737
GeneIDi18718
KEGGimmu:18718
UCSCiuc008imb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009615 mRNA Translation: BAA25676.1
BC011097 mRNA Translation: AAH11097.1
CCDSiCCDS15712.1
RefSeqiNP_032871.3, NM_008845.4
UniGeneiMm.313977

3D structure databases

ProteinModelPortaliO70172
SMRiO70172
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-49438N
IntActiO70172, 7 interactors
MINTiO70172
STRINGi10090.ENSMUSP00000006912

PTM databases

iPTMnetiO70172
PhosphoSitePlusiO70172

Proteomic databases

EPDiO70172
PaxDbiO70172
PeptideAtlasiO70172
PRIDEiO70172

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006912; ENSMUSP00000006912; ENSMUSG00000026737
GeneIDi18718
KEGGimmu:18718
UCSCiuc008imb.1 mouse

Organism-specific databases

CTDi5305
MGIiMGI:1298206 Pip4k2a

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiO70172
KOiK00920
OMAiANDSQAR
OrthoDBiEOG091G0857
PhylomeDBiO70172
TreeFamiTF354315

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-6811555 PI5P Regulates TP53 Acetylation
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847453 Synthesis of PIPs in the nucleus

Miscellaneous databases

PROiPR:O70172
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026737 Expressed in 312 organ(s), highest expression level in ventral horn of spinal cord
ExpressionAtlasiO70172 baseline and differential
GenevisibleiO70172 MM

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 1 hit
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPI42A_MOUSE
AccessioniPrimary (citable) accession number: O70172
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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