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Protein

Stathmin-3

Gene

Stmn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.1 Publication

GO - Molecular functioni

  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: HGNC
  • tubulin binding Source: GO_Central

GO - Biological processi

  • cytoplasmic microtubule organization Source: HGNC
  • microtubule depolymerization Source: GO_Central
  • negative regulation of Rac protein signal transduction Source: HGNC
  • neuron projection development Source: HGNC
  • regulation of cytoskeleton organization Source: HGNC
  • regulation of GTPase activity Source: HGNC
  • regulation of microtubule polymerization or depolymerization Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-3
Alternative name(s):
Hippocampus abundant transcript 3
SCG10-like protein
SCG10-related protein HiAT3
Gene namesi
Name:Stmn3
Synonyms:Sclip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1277137 Stmn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824031 – 180Stathmin-3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22S-palmitoyl cysteineBy similarity1
Lipidationi24S-palmitoyl cysteineBy similarity1
Modified residuei50PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei81PhosphoserineBy similarity1

Post-translational modificationi

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO70166
PeptideAtlasiO70166
PRIDEiO70166

PTM databases

iPTMnetiO70166
PhosphoSitePlusiO70166

Expressioni

Tissue specificityi

Neuron specific.

Gene expression databases

BgeeiENSMUSG00000027581
CleanExiMM_STMN3
ExpressionAtlasiO70166 baseline and differential
GenevisibleiO70166 MM

Interactioni

Subunit structurei

Interacts with STAT3.1 Publication

GO - Molecular functioni

  • protein C-terminus binding Source: MGI
  • protein domain specific binding Source: HGNC
  • tubulin binding Source: GO_Central

Protein-protein interaction databases

BioGridi203096, 2 interactors
IntActiO70166, 1 interactor
STRINGi10090.ENSMUSP00000099334

Structurei

3D structure databases

ProteinModelPortaliO70166
SMRiO70166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 180SLDPROSITE-ProRule annotationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 179Sequence analysisAdd BLAST105

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEAZ Eukaryota
ENOG4111H1E LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiO70166
OMAiMEMSKEN
OrthoDBiEOG091G0Y2U
PhylomeDBiO70166
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR028835 Stathmin-3
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PTHR10104:SF17 PTHR10104:SF17, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequencei

Sequence statusi: Complete.

O70166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTVSAYKE KMKELSVLSL ICSCFYSQPH PNTIYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPV LSSPPKRKDA SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSR LAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Length:180
Mass (Da):20,954
Last modified:August 1, 1998 - v1
Checksum:iA7C0D35A6A684765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007912 mRNA Translation: BAA28629.1
AF069708 mRNA Translation: AAC21575.1
BC057017 mRNA Translation: AAH57017.1
CCDSiCCDS17207.1
RefSeqiNP_033159.1, NM_009133.3
UniGeneiMm.2319
Mm.447659

Genome annotation databases

EnsembliENSMUST00000103045; ENSMUSP00000099334; ENSMUSG00000027581
GeneIDi20262
KEGGimmu:20262
UCSCiuc008olt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSTMN3_MOUSE
AccessioniPrimary (citable) accession number: O70166
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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