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Protein

Dolichol-phosphate mannosyltransferase subunit 1

Gene

Dpm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.By similarity

Catalytic activityi

GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-162699 Synthesis of dolichyl-phosphate mannose
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichol-phosphate mannosyltransferase subunit 1 (EC:2.4.1.83)
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 1
Short name:
DPM synthase subunit 1
Dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Mannose-P-dolichol synthase subunit 1
Short name:
MPD synthase
Gene namesi
Name:Dpm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1330239 Dpm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000591712 – 260Dolichol-phosphate mannosyltransferase subunit 1Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70152
MaxQBiO70152
PaxDbiO70152
PeptideAtlasiO70152
PRIDEiO70152

PTM databases

iPTMnetiO70152
PhosphoSitePlusiO70152

Expressioni

Gene expression databases

BgeeiENSMUSG00000078919 Expressed in 216 organ(s), highest expression level in testis
CleanExiMM_DPM1
ExpressionAtlasiO70152 baseline and differential
GenevisibleiO70152 MM

Interactioni

Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3.By similarity

Protein-protein interaction databases

BioGridi199298, 1 interactor
IntActiO70152, 2 interactors
MINTiO70152
STRINGi10090.ENSMUSP00000118776

Structurei

3D structure databases

ProteinModelPortaliO70152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

eggNOGiKOG2978 Eukaryota
COG0463 LUCA
GeneTreeiENSGT00550000075000
HOVERGENiHBG018967
InParanoidiO70152
KOiK00721
OMAiFQVEMNY
OrthoDBiEOG091G0IGG
PhylomeDBiO70152
TreeFamiTF105617

Family and domain databases

CDDicd06442 DPM1_like, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR039528 DPM1-like
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR43398 PTHR43398, 1 hit
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGASRSL AASPRPPQGR SSRQDKYSVL LPTYNERENL PLIVWLLVKS
60 70 80 90 100
FSESAINYEI IIIDDGSPDG TREVAEQLAE IYGPDRILLR PREKKLGLGT
110 120 130 140 150
AYIHGIKHAT GNYVIIMDAD LSHHPKFIPE FIRKQKEGNF DIVSGTRYKG
160 170 180 190 200
NGGVYGWDLK RKIISRGANF ITQILLRPGA SDLTGSFRLY RKEVLQKLIE
210 220 230 240 250
KCVSKGYVFQ MEMIVRARQM NYTIGEVPIS FVDRVYGESK LGGNEIVSFL
260
KGLLTLFATT
Length:260
Mass (Da):29,175
Last modified:August 1, 1998 - v1
Checksum:i8CB1BCDF1977EBA6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2BDX2A2BDX2_MOUSE
Dolichol-phosphate mannosyltransfer...
Dpm1
208Annotation score:
F8WII3F8WII3_MOUSE
Dolichol-phosphate mannosyltransfer...
Dpm1
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76E → G in BAB25735 (PubMed:16141072).Curated1
Sequence conflicti122S → Y in BAB25735 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004789 mRNA Translation: BAA25759.1
AK005268 mRNA Translation: BAB23920.1
AK004834 mRNA Translation: BAB23602.1
AK008548 mRNA Translation: BAB25735.1
BC061151 mRNA Translation: AAH61151.1
CCDSiCCDS17109.1
RefSeqiNP_001297013.1, NM_001310084.1
NP_034202.1, NM_010072.4
UniGeneiMm.422657

Genome annotation databases

EnsembliENSMUST00000138667; ENSMUSP00000139070; ENSMUSG00000093752
ENSMUST00000154111; ENSMUSP00000118776; ENSMUSG00000078919
GeneIDi13480
KEGGimmu:13480
UCSCiuc008oas.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004789 mRNA Translation: BAA25759.1
AK005268 mRNA Translation: BAB23920.1
AK004834 mRNA Translation: BAB23602.1
AK008548 mRNA Translation: BAB25735.1
BC061151 mRNA Translation: AAH61151.1
CCDSiCCDS17109.1
RefSeqiNP_001297013.1, NM_001310084.1
NP_034202.1, NM_010072.4
UniGeneiMm.422657

3D structure databases

ProteinModelPortaliO70152
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199298, 1 interactor
IntActiO70152, 2 interactors
MINTiO70152
STRINGi10090.ENSMUSP00000118776

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

PTM databases

iPTMnetiO70152
PhosphoSitePlusiO70152

Proteomic databases

EPDiO70152
MaxQBiO70152
PaxDbiO70152
PeptideAtlasiO70152
PRIDEiO70152

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000138667; ENSMUSP00000139070; ENSMUSG00000093752
ENSMUST00000154111; ENSMUSP00000118776; ENSMUSG00000078919
GeneIDi13480
KEGGimmu:13480
UCSCiuc008oas.1 mouse

Organism-specific databases

CTDi8813
MGIiMGI:1330239 Dpm1

Phylogenomic databases

eggNOGiKOG2978 Eukaryota
COG0463 LUCA
GeneTreeiENSGT00550000075000
HOVERGENiHBG018967
InParanoidiO70152
KOiK00721
OMAiFQVEMNY
OrthoDBiEOG091G0IGG
PhylomeDBiO70152
TreeFamiTF105617

Enzyme and pathway databases

UniPathwayi
UPA00378

ReactomeiR-MMU-162699 Synthesis of dolichyl-phosphate mannose

Miscellaneous databases

PROiPR:O70152
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078919 Expressed in 216 organ(s), highest expression level in testis
CleanExiMM_DPM1
ExpressionAtlasiO70152 baseline and differential
GenevisibleiO70152 MM

Family and domain databases

CDDicd06442 DPM1_like, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR039528 DPM1-like
IPR001173 Glyco_trans_2-like
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR43398 PTHR43398, 1 hit
PfamiView protein in Pfam
PF00535 Glycos_transf_2, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPM1_MOUSE
AccessioniPrimary (citable) accession number: O70152
Secondary accession number(s): Q9D829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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