UniProtKB - O70142 (SHC2_RAT)
Protein
SHC-transforming protein 2
Gene
Shc2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).By similarity
GO - Molecular functioni
- protein kinase binding Source: GO_Central
- receptor tyrosine kinase binding Source: GO_Central
GO - Biological processi
- activation of MAPK activity Source: InterPro
- intracellular signal transduction Source: InterPro
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Enzyme and pathway databases
Reactomei | R-RNO-167044, Signalling to RAS R-RNO-4420097, VEGFA-VEGFR2 Pathway R-RNO-5673001, RAF/MAP kinase cascade |
Names & Taxonomyi
Protein namesi | Recommended name: SHC-transforming protein 2Alternative name(s): Protein Sck SH2 domain protein C2 Src homology 2 domain-containing-transforming protein C2 |
Gene namesi | Name:Shc2 Synonyms:Sck |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307137, Shc2 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000342264 | 1 – 573 | SHC-transforming protein 2Add BLAST | 573 |
Post-translational modificationi
Phosphorylated on tyrosine by the Trk receptors.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | O70142 |
PRIDEi | O70142 |
PTM databases
iPTMneti | O70142 |
PhosphoSitePlusi | O70142 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000008030, Expressed in frontal cortex and 20 other tissues |
Genevisiblei | O70142, RN |
Interactioni
Subunit structurei
Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2 (By similarity).
By similarityGO - Molecular functioni
- protein kinase binding Source: GO_Central
- receptor tyrosine kinase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010714 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 125 – 307 | PIDPROSITE-ProRule annotationAdd BLAST | 183 | |
Domaini | 478 – 569 | SH2PROSITE-ProRule annotationAdd BLAST | 92 |
Domaini
The PID domain mediates binding to the TrkA receptor.By similarity
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG3697, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_029532_2_0_1 |
InParanoidi | O70142 |
OMAi | WKFAAPG |
OrthoDBi | 1351843at2759 |
PhylomeDBi | O70142 |
TreeFami | TF315807 |
Family and domain databases
CDDi | cd01209, PTB_Shc, 1 hit cd09925, SH2_SHC, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006019, PID_Shc-like IPR006020, PTB/PI_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR029591, SHC2 IPR035676, SHC_SH2 |
PANTHERi | PTHR10337:SF5, PTHR10337:SF5, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00629, SHCPIDOMAIN |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50001, SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
O70142-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQGPGGRAA PEPEAPTTFC ALLPRMPQWK FAAPGSFLGR GPAAARVAGA
60 70 80 90 100
AEAQPEPGVP ALAAVLGACE PRCAAPCPLP ALGRCRGSGS RGARGTPDVA
110 120 130 140 150
DEWVRKGGFI HKPAHGWLHP DARVLGPGVS YIVRYMGCIE VLRSMRSLDF
160 170 180 190 200
NTRTQVTREA INRLHEAVPG VRGSWKKKAP NKALASILGK SNLRFAGMSI
210 220 230 240 250
SVNISVDGLN LSVPATRQII ANHHMQSISF ASGGDTDMTD YVAYVAKDPI
260 270 280 290 300
NQRACHILEC CEGLAQSVIS TVGQAFELRF KQYLHSPPKA VVPPERLTGL
310 320 330 340 350
EESAWGDGEV TADHDYYNSI PGKEPPLGGL VDSRLAVTQP CALTTLGGLG
360 370 380 390 400
QGLSPAWRDV RGLPWDMGPS GAVPPGDGYV QADARGPHDY EEHLYVNTQG
410 420 430 440 450
LDALELEDTS ETPLQPEDSP KKDLFDMRPF EDALKLHECS VAAGITAASL
460 470 480 490 500
PLEDQWPSPP TRRAPIAPTE EQLRQEPWYH GRMSRRAAEK LLRADGDFLV
510 520 530 540 550
RDSITNPGQY VLTGMHAGQP KHLLLVDPEG VVRTKDVLFE SISHLIDYHL
560 570
KNGLPIVAAE SELHLRGVVS REP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03055985 Genomic DNA No translation available. AABR03059160 Genomic DNA No translation available. AB001452 mRNA Translation: BAA28173.1 |
RefSeqi | NP_001101535.1, NM_001108065.1 |
Genome annotation databases
Ensembli | ENSRNOT00000010714; ENSRNOP00000010714; ENSRNOG00000008030 |
GeneIDi | 314612 |
KEGGi | rno:314612 |
UCSCi | RGD:1307137, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03055985 Genomic DNA No translation available. AABR03059160 Genomic DNA No translation available. AB001452 mRNA Translation: BAA28173.1 |
RefSeqi | NP_001101535.1, NM_001108065.1 |
3D structure databases
SMRi | O70142 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010714 |
PTM databases
iPTMneti | O70142 |
PhosphoSitePlusi | O70142 |
Proteomic databases
PaxDbi | O70142 |
PRIDEi | O70142 |
Genome annotation databases
Ensembli | ENSRNOT00000010714; ENSRNOP00000010714; ENSRNOG00000008030 |
GeneIDi | 314612 |
KEGGi | rno:314612 |
UCSCi | RGD:1307137, rat |
Organism-specific databases
CTDi | 25759 |
RGDi | 1307137, Shc2 |
Phylogenomic databases
eggNOGi | KOG3697, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_029532_2_0_1 |
InParanoidi | O70142 |
OMAi | WKFAAPG |
OrthoDBi | 1351843at2759 |
PhylomeDBi | O70142 |
TreeFami | TF315807 |
Enzyme and pathway databases
Reactomei | R-RNO-167044, Signalling to RAS R-RNO-4420097, VEGFA-VEGFR2 Pathway R-RNO-5673001, RAF/MAP kinase cascade |
Miscellaneous databases
PROi | PR:O70142 |
Gene expression databases
Bgeei | ENSRNOG00000008030, Expressed in frontal cortex and 20 other tissues |
Genevisiblei | O70142, RN |
Family and domain databases
CDDi | cd01209, PTB_Shc, 1 hit cd09925, SH2_SHC, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006019, PID_Shc-like IPR006020, PTB/PI_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR029591, SHC2 IPR035676, SHC_SH2 |
PANTHERi | PTHR10337:SF5, PTHR10337:SF5, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00629, SHCPIDOMAIN |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHC2_RAT | |
Accessioni | O70142Primary (citable) accession number: O70142 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |