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Protein

cAMP-dependent protein kinase inhibitor gamma

Gene

Pkig

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

GO - Molecular functioni

  • cAMP-dependent protein kinase inhibitor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor gamma
Short name:
PKI-gamma
Gene namesi
Name:Pkig
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1343086 Pkig

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545431 – 76cAMP-dependent protein kinase inhibitor gammaAdd BLAST76

Proteomic databases

PaxDbiO70139
PRIDEiO70139

PTM databases

PhosphoSitePlusiO70139

Expressioni

Gene expression databases

BgeeiENSMUSG00000035268 Expressed in 292 organ(s), highest expression level in ear vesicle
CleanExiMM_PKIG
ExpressionAtlasiO70139 baseline and differential
GenevisibleiO70139 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068344

Structurei

3D structure databases

SMRiO70139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410J1ME Eukaryota
ENOG410ZDGT LUCA
GeneTreeiENSGT00390000002707
HOGENOMiHOG000059641
HOVERGENiHBG104492
InParanoidiO70139
OMAiTDFISCD
OrthoDBiEOG091G13WE
PhylomeDBiO70139
TreeFamiTF330809

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O70139-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA
60 70
EGQAEGSTPD KEASSQPESS DANTSS
Length:76
Mass (Da):7,943
Last modified:August 1, 1998 - v1
Checksum:i965F577D80C8DE59
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZC22B7ZC22_MOUSE
cAMP-dependent protein kinase inhib...
Pkig
71Annotation score:
B7ZC21B7ZC21_MOUSE
cAMP-dependent protein kinase inhib...
Pkig
56Annotation score:
B7ZC20B7ZC20_MOUSE
cAMP-dependent protein kinase inhib...
Pkig
16Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97170 mRNA Translation: AAC09065.1
BC026550 mRNA Translation: AAH26550.1
CCDSiCCDS17014.1
RefSeqiNP_001034479.1, NM_001039390.2
NP_001034480.1, NM_001039391.2
NP_001157525.1, NM_001164053.1
NP_001157527.1, NM_001164055.1
NP_035236.1, NM_011106.2
XP_006498989.1, XM_006498926.3
XP_006498990.1, XM_006498927.1
UniGeneiMm.10091

Genome annotation databases

EnsembliENSMUST00000064703; ENSMUSP00000068344; ENSMUSG00000035268
ENSMUST00000099105; ENSMUSP00000096704; ENSMUSG00000035268
ENSMUST00000109400; ENSMUSP00000105027; ENSMUSG00000035268
ENSMUST00000126182; ENSMUSP00000120145; ENSMUSG00000035268
ENSMUST00000164399; ENSMUSP00000126223; ENSMUSG00000035268
GeneIDi18769
KEGGimmu:18769
UCSCiuc008nth.2 mouse

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97170 mRNA Translation: AAC09065.1
BC026550 mRNA Translation: AAH26550.1
CCDSiCCDS17014.1
RefSeqiNP_001034479.1, NM_001039390.2
NP_001034480.1, NM_001039391.2
NP_001157525.1, NM_001164053.1
NP_001157527.1, NM_001164055.1
NP_035236.1, NM_011106.2
XP_006498989.1, XM_006498926.3
XP_006498990.1, XM_006498927.1
UniGeneiMm.10091

3D structure databases

SMRiO70139
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068344

PTM databases

PhosphoSitePlusiO70139

Proteomic databases

PaxDbiO70139
PRIDEiO70139

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064703; ENSMUSP00000068344; ENSMUSG00000035268
ENSMUST00000099105; ENSMUSP00000096704; ENSMUSG00000035268
ENSMUST00000109400; ENSMUSP00000105027; ENSMUSG00000035268
ENSMUST00000126182; ENSMUSP00000120145; ENSMUSG00000035268
ENSMUST00000164399; ENSMUSP00000126223; ENSMUSG00000035268
GeneIDi18769
KEGGimmu:18769
UCSCiuc008nth.2 mouse

Organism-specific databases

CTDi11142
MGIiMGI:1343086 Pkig

Phylogenomic databases

eggNOGiENOG410J1ME Eukaryota
ENOG410ZDGT LUCA
GeneTreeiENSGT00390000002707
HOGENOMiHOG000059641
HOVERGENiHBG104492
InParanoidiO70139
OMAiTDFISCD
OrthoDBiEOG091G13WE
PhylomeDBiO70139
TreeFamiTF330809

Miscellaneous databases

ChiTaRSiPkig mouse
PROiPR:O70139
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035268 Expressed in 292 organ(s), highest expression level in ear vesicle
CleanExiMM_PKIG
ExpressionAtlasiO70139 baseline and differential
GenevisibleiO70139 MM

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPKG_MOUSE
AccessioniPrimary (citable) accession number: O70139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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