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Protein

Homeobox protein aristaless-like 3

Gene

Alx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator with a possible role in patterning of mesoderm during development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi153 – 212HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein aristaless-like 3
Alternative name(s):
Proline-rich transcription factor ALX3
Gene namesi
Name:Alx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1277097 Alx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488131 – 343Homeobox protein aristaless-like 3Add BLAST343

Proteomic databases

PaxDbiO70137
PRIDEiO70137

PTM databases

iPTMnetiO70137
PhosphoSitePlusiO70137

Expressioni

Tissue specificityi

Predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Prominent expression in frontonasal head mesenchyme and in the first and second pharyngeal arches and some of their derivatives. High expression is also seen in the tail and in many derivatives of the lateral plate mesoderm including the limbs, the body wall, and the genital tubercle.

Developmental stagei

Expressed in embryos from 8 days of gestation onward.

Gene expression databases

BgeeiENSMUSG00000014603 Expressed in 190 organ(s), highest expression level in frontonasal prominence
CleanExiMM_ALX3
ExpressionAtlasiO70137 baseline and differential
GenevisibleiO70137 MM

Interactioni

Protein-protein interaction databases

BioGridi198080, 1 interactor
STRINGi10090.ENSMUSP00000014747

Structurei

3D structure databases

ProteinModelPortaliO70137
SMRiO70137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000231518
HOVERGENiHBG004213
InParanoidiO70137
KOiK09323
OMAiSIHGFPP
OrthoDBiEOG091G0B1L
PhylomeDBiO70137
TreeFamiTF350743

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR033211 ALX3
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PANTHERiPTHR24329:SF340 PTHR24329:SF340, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70137-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPERCAPFS VGPAAGPYAA AGDEAPGPQG TPDAAPHLHP APPRGPRLSR
60 70 80 90 100
FPACGPLEPY LPEPAKPPAK YLQDLGPGPV LNGGHFYEGS AEAEEKASKA
110 120 130 140 150
ASFPQLPVDC RGGPRDGPSN VQASPGPCLA SLSVPLSPGL PDSMELAKTK
160 170 180 190 200
SKKRRNRTTF STFQLEELEK VFQKTHYPDV YAREQLALRT DLTEARVQVW
210 220 230 240 250
FQNRRAKWRK RERYGKMQEG RNPFTTAYDI SVLPRTDSHP QLQNSLWPSP
260 270 280 290 300
GSGSPGGPCL MSPEGIPSPC MSPYSHSHGN VAGFMGVPAS PAAHPGIYSI
310 320 330 340
HGFPPALGGH SFEPSPDGDY KSPSLVSLRM KPKEPPGLLN WTT
Length:343
Mass (Da):36,851
Last modified:August 1, 1998 - v1
Checksum:i87900BF977FACD2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96109 mRNA Translation: AAC15094.1
CCDSiCCDS17739.1
RefSeqiNP_031467.1, NM_007441.3
UniGeneiMm.10112

Genome annotation databases

EnsembliENSMUST00000014747; ENSMUSP00000014747; ENSMUSG00000014603
GeneIDi11694
KEGGimmu:11694
UCSCiuc008qxf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96109 mRNA Translation: AAC15094.1
CCDSiCCDS17739.1
RefSeqiNP_031467.1, NM_007441.3
UniGeneiMm.10112

3D structure databases

ProteinModelPortaliO70137
SMRiO70137
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198080, 1 interactor
STRINGi10090.ENSMUSP00000014747

PTM databases

iPTMnetiO70137
PhosphoSitePlusiO70137

Proteomic databases

PaxDbiO70137
PRIDEiO70137

Protocols and materials databases

DNASUi11694
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014747; ENSMUSP00000014747; ENSMUSG00000014603
GeneIDi11694
KEGGimmu:11694
UCSCiuc008qxf.2 mouse

Organism-specific databases

CTDi257
MGIiMGI:1277097 Alx3

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000231518
HOVERGENiHBG004213
InParanoidiO70137
KOiK09323
OMAiSIHGFPP
OrthoDBiEOG091G0B1L
PhylomeDBiO70137
TreeFamiTF350743

Miscellaneous databases

PROiPR:O70137
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014603 Expressed in 190 organ(s), highest expression level in frontonasal prominence
CleanExiMM_ALX3
ExpressionAtlasiO70137 baseline and differential
GenevisibleiO70137 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR033211 ALX3
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PANTHERiPTHR24329:SF340 PTHR24329:SF340, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALX3_MOUSE
AccessioniPrimary (citable) accession number: O70137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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