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Protein

Ninjurin-1

Gene

Ninj1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • hyaloid vascular plexus regression Source: MGI
  • positive regulation of cell-matrix adhesion Source: MGI
  • tissue regeneration Source: InterPro

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-1
Alternative name(s):
Nerve injury-induced protein 1
Gene namesi
Name:Ninj1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1196617 Ninj1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79ExtracellularSequence analysisAdd BLAST79
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 120CytoplasmicSequence analysisAdd BLAST20
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 152ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596441 – 152Ninjurin-1Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70131
PRIDEiO70131

PTM databases

PhosphoSitePlusiO70131

Expressioni

Inductioni

By nerve injury.

Gene expression databases

BgeeiENSMUSG00000037966 Expressed in 305 organ(s), highest expression level in primary oocyte
CleanExiMM_NINJ1
ExpressionAtlasiO70131 baseline and differential
GenevisibleiO70131 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036740

Structurei

3D structure databases

ProteinModelPortaliO70131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIJ Eukaryota
ENOG4111RPK LUCA
GeneTreeiENSGT00390000012754
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiO70131
OMAiNINHYAN
PhylomeDBiO70131
TreeFamiTF323538

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
IPR015639 Ninjurin1
PANTHERiPTHR12316 PTHR12316, 1 hit
PTHR12316:SF19 PTHR12316:SF19, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70131-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESGTEEYEL NGDLRPGSPG SPDALPPRWG LRNRPINVNH YANKKSAAES
60 70 80 90 100
MLDIALLMAN ASQLKAVVEQ GNDFAFFVPL VVLISISLVL QIGVGVLLIF
110 120 130 140 150
LVKYDLNNPA KHAKLDFLNN LATGLVFIIV VVNIFITAFG VQKPVMDVAP

RQ
Length:152
Mass (Da):16,555
Last modified:August 1, 1998 - v1
Checksum:iE261CB447BC0A2E6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFN5D6RFN5_MOUSE
Ninjurin-1
Ninj1
110Annotation score:
D3YW25D3YW25_MOUSE
Ninjurin 1, isoform CRA_a
Ninj1 mCG_15642
210Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91513 mRNA Translation: AAC14594.1
AF219626 Genomic DNA Translation: AAG32161.1
CCDSiCCDS26497.1
RefSeqiNP_038638.1, NM_013610.2
UniGeneiMm.18503

Genome annotation databases

EnsembliENSMUST00000049022; ENSMUSP00000036740; ENSMUSG00000037966
GeneIDi18081
KEGGimmu:18081
UCSCiuc007qiw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91513 mRNA Translation: AAC14594.1
AF219626 Genomic DNA Translation: AAG32161.1
CCDSiCCDS26497.1
RefSeqiNP_038638.1, NM_013610.2
UniGeneiMm.18503

3D structure databases

ProteinModelPortaliO70131
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036740

PTM databases

PhosphoSitePlusiO70131

Proteomic databases

PaxDbiO70131
PRIDEiO70131

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049022; ENSMUSP00000036740; ENSMUSG00000037966
GeneIDi18081
KEGGimmu:18081
UCSCiuc007qiw.1 mouse

Organism-specific databases

CTDi4814
MGIiMGI:1196617 Ninj1

Phylogenomic databases

eggNOGiENOG410IWIJ Eukaryota
ENOG4111RPK LUCA
GeneTreeiENSGT00390000012754
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiO70131
OMAiNINHYAN
PhylomeDBiO70131
TreeFamiTF323538

Miscellaneous databases

PROiPR:O70131
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037966 Expressed in 305 organ(s), highest expression level in primary oocyte
CleanExiMM_NINJ1
ExpressionAtlasiO70131 baseline and differential
GenevisibleiO70131 MM

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
IPR015639 Ninjurin1
PANTHERiPTHR12316 PTHR12316, 1 hit
PTHR12316:SF19 PTHR12316:SF19, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNINJ1_MOUSE
AccessioniPrimary (citable) accession number: O70131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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