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Protein
Submitted name:

Serralysin

Gene

PAPRA

Organism
Pseudomonas sp. 'TAC II 18'
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi66Calcium 1Combined sources1
Metal bindingi68Calcium 1Combined sources1
Metal bindingi70Calcium 1Combined sources1
Metal bindingi72Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi74Calcium 1Combined sources1
Metal bindingi131Calcium 1Combined sources1
Metal bindingi186Zinc; via tele nitrogenCombined sources1
Metal bindingi186Zinc; via tele nitrogen; catalyticUniRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei187UniRule annotation1
Metal bindingi190Zinc; via tele nitrogenCombined sources1
Metal bindingi190Zinc; via tele nitrogen; catalyticUniRule annotation1
Metal bindingi196Zinc; via tele nitrogenCombined sources1
Metal bindingi196Zinc; via tele nitrogen; catalyticUniRule annotation1
Metal bindingi267Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi269Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi271Calcium 2Combined sources1
Metal bindingi299Calcium 2Combined sources1
Metal bindingi301Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi302Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi304Calcium 2Combined sources1
Metal bindingi304Calcium 3Combined sources1
Metal bindingi341Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi343Calcium 3Combined sources1
Metal bindingi348Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi350Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi352Calcium 4Combined sources1
Metal bindingi357Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi359Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi361Calcium 5Combined sources1
Metal bindingi365Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi366Calcium 6; via carbonyl oxygenCombined sources1
Metal bindingi367Calcium 4; via carbonyl oxygenCombined sources1
Metal bindingi367Calcium 6Combined sources1
Metal bindingi368Calcium 6; via amide nitrogen and carbonyl oxygenCombined sources1
Metal bindingi370Calcium 4Combined sources1
Metal bindingi370Calcium 6Combined sources1
Metal bindingi374Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi375Calcium 7; via carbonyl oxygenCombined sources1
Metal bindingi376Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi377Calcium 7; via carbonyl oxygenCombined sources1
Metal bindingi379Calcium 5Combined sources1
Metal bindingi379Calcium 7Combined sources1
Metal bindingi383Calcium 6; via carbonyl oxygenCombined sources1
Metal bindingi384Calcium 8; via carbonyl oxygenCombined sources1
Metal bindingi385Calcium 6; via carbonyl oxygenCombined sources1
Metal bindingi386Calcium 8; via carbonyl oxygenCombined sources1
Metal bindingi388Calcium 6Combined sources1
Metal bindingi388Calcium 8Combined sources1
Metal bindingi397Calcium 7; via carbonyl oxygenCombined sources1
Metal bindingi404Calcium 7Combined sources1
Metal bindingi410Calcium 8Combined sources1
Metal bindingi414Calcium 8Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported
LigandCalciumCombined sources, Metal-bindingUniRule annotationCombined sources, ZincUniRule annotationCombined sources

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M10.062

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SerralysinImported (EC:3.4.24.40Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAPRAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas sp. 'TAC II 18'Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri76981 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O69771

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O69771

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O69771

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 238ZnMcInterPro annotationAdd BLAST166

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04277 ZnMc_serralysin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.150.10.10, 1 hit
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR024079 MetalloPept_cat_dom_sf
IPR016294 Pept_M10B
IPR013858 Peptidase_M10B_C
IPR006026 Peptidase_Metallo
IPR034033 Serralysin-like
IPR011049 Serralysin-like_metalloprot_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00353 HemolysinCabind, 1 hit
PF08548 Peptidase_M10_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001205 Peptidase_M10B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00235 ZnMc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51120 SSF51120, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O69771-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLKEKAAL SVNQTFAANG TSSAFTQIDN FSHFYDRGEH LVNGKPSFTV
60 70 80 90 100
DQVADQLTRS GASWHDLNND GVINLTYTFL TAPPVGYASR GLGTFSQFSA
110 120 130 140 150
LQKEQAKLSL ESWADVAKVT FTEGPAARGD DGHMTFANFS ASNGGAAFAY
160 170 180 190 200
LPNSSRKGES WYLINKDYQV NKTPGEGNYG RQTLTHEIGH TLGLSHPGDY
210 220 230 240 250
NAGNGNPTYR DAVYAEDTRA YSVMSYWSEK NTGQVFTKTG EGAYASAPLL
260 270 280 290 300
DDIAAVQKLY GANLETRADD TVYGFNSTAD RDFYSATSST DKLIFSVWDG
310 320 330 340 350
GGNDTLDFSG FSQNQKINLT AGSFSDVGGM TGNVSIAQGV TIENAIGGSG
360 370 380 390 400
NDLLIGNDAA NVLKGGAGND IIYGGGGADV LWGGTGSDTF VFGAVSDSTP
410 420 430 440 450
KAADIIKDFQ SGFDKIDLTA ITKLGGLNFV DAFTGHAGDA IVSYHQASNA
460 470 480
GSLQVDFSGQ GVADFLVTTV GQVATYDIVA
Length:480
Mass (Da):50,554
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i674A5C01AF1225C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y17314 Genomic DNA Translation: CAA76737.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17314 Genomic DNA Translation: CAA76737.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G9KX-ray1.96A18-480[»]
1H71X-ray2.10P18-480[»]
1O0QX-ray2.20A18-480[»]
1O0TX-ray2.50A18-480[»]
1OM6X-ray2.00A18-480[»]
1OM7X-ray2.80A18-480[»]
1OM8X-ray2.00A18-480[»]
1OMJX-ray2.38A18-480[»]
ProteinModelPortaliO69771
SMRiO69771
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM10.062

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO69771

Family and domain databases

CDDicd04277 ZnMc_serralysin_like, 1 hit
Gene3Di2.150.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR018511 Hemolysin-typ_Ca-bd_CS
IPR001343 Hemolysn_Ca-bd
IPR024079 MetalloPept_cat_dom_sf
IPR016294 Pept_M10B
IPR013858 Peptidase_M10B_C
IPR006026 Peptidase_Metallo
IPR034033 Serralysin-like
IPR011049 Serralysin-like_metalloprot_C
PfamiView protein in Pfam
PF00353 HemolysinCabind, 1 hit
PF08548 Peptidase_M10_C, 1 hit
PIRSFiPIRSF001205 Peptidase_M10B, 1 hit
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit
SUPFAMiSSF51120 SSF51120, 1 hit
PROSITEiView protein in PROSITE
PS00330 HEMOLYSIN_CALCIUM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO69771_9PSED
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O69771
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: December 5, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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