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Protein

HTH-type transcriptional regulator NmtR

Gene

nmtR

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Represses transcription of ctpJ/nmtA, by binding to its promoter region.1 Publication

Activity regulationi

Binding to DNA is inhibited by nickel and, to some extent, cobalt ions.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Nickel1
Metal bindingi93Nickel1
Metal bindingi104Nickel1
Metal bindingi107Nickel1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 72H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • regulation of fatty acid metabolic process Source: MTBBASE
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Nickel

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator NmtR
Gene namesi
Name:nmtR
Ordered Locus Names:Rv3744
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3744

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51D → A: Does not affect activity and regulation by metal ions. 1 Publication1
Mutagenesisi91D → A: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi93H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi104H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi107H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi109H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1
Mutagenesisi114D → A: Does not affect activity and regulation by metal ions. 1 Publication1
Mutagenesisi116H → R: No change in activity. Lack of regulation by metal ions. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004191791 – 120HTH-type transcriptional regulator NmtRAdd BLAST120

Proteomic databases

PaxDbiO69711
PRIDEiO69711

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv3744

Structurei

3D structure databases

ProteinModelPortaliO69711
SMRiO69711
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 109HTH arsR-typePROSITE-ProRule annotationAdd BLAST95

Phylogenomic databases

eggNOGiENOG41066UM Bacteria
ENOG41124TA LUCA
HOGENOMiHOG000144506
InParanoidiO69711
KOiK21886
OMAiVGMEQSA
PhylomeDBiO69711

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O69711-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHGVEGRNR PSAPLDSQAA AQVASTLQAL ATPSRLMILT QLRNGPLPVT
60 70 80 90 100
DLAEAIGMEQ SAVSHQLRVL RNLGLVVGDR AGRSIVYSLY DTHVAQLLDE
110 120
AIYHSEHLHL GLSDRHPSAG
Length:120
Mass (Da):12,836
Last modified:July 5, 2004 - v3
Checksum:iEC9D7491B06A61E5
GO

Mass spectrometryi

Molecular mass is 12699.7 Da from positions 2 - 120. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46571.1
PIRiA70799
RefSeqiNP_218261.1, NC_000962.3
WP_003901716.1, NZ_KK339374.1

Genome annotation databases

EnsemblBacteriaiCCP46571; CCP46571; Rv3744
GeneIDi885418
KEGGimtu:Rv3744

Similar proteinsi

Entry informationi

Entry nameiNMTR_MYCTU
AccessioniPrimary (citable) accession number: O69711
Secondary accession number(s): L0TGE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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