UniProtKB - O69687 (FAMT_MYCTU)
Protein
Probable fatty acid methyltransferase Rv3720
Gene
Rv3720
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
May be a S-adenosylmethionine-dependent methyltransferase involved in fatty acid metabolism.Curated
GO - Molecular functioni
- methyltransferase activity Source: UniProtKB-KW
GO - Biological processi
- lipid biosynthetic process Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-8007-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable fatty acid methyltransferase Rv3720 (EC:2.1.1.-)Alternative name(s): S-adenosylmethionine-dependent methyltransferase Rv3720 Short name: AdoMet-MT Short name: SAM-MT |
Gene namesi | Ordered Locus Names:Rv3720Imported, RVBD_3720Imported, LH57_20270Imported ORF Names:P425_03869Imported |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3720 |
Subcellular locationi
GO - Cellular componenti
- cell wall Source: MTBBASE
- plasma membrane Source: MTBBASE
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000432511 | 1 – 427 | Probable fatty acid methyltransferase Rv3720Add BLAST | 427 |
Proteomic databases
PaxDbi | O69687 |
PRIDEi | O69687 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 167 – 168 | S-adenosyl-L-methionine bindingBy similarity | 2 | |
Regioni | 202 – 210 | S-adenosyl-L-methionine bindingBy similarity | 9 | |
Regioni | 227 – 232 | S-adenosyl-L-methionine bindingBy similarity | 6 |
Sequence similaritiesi
Belongs to the CFA/CMAS family.Curated
Phylogenomic databases
eggNOGi | ENOG4105CV9 Bacteria COG2230 LUCA |
HOGENOMi | HOG000245192 |
InParanoidi | O69687 |
KOi | K00574 |
Family and domain databases
InterProi | View protein in InterPro IPR003333 Mycolic_cyclopropane_synthase IPR029063 SAM-dependent_MTases |
PIRSFi | PIRSF003085 CMAS, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
O69687-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTGRLSMAE ILEIFTATGQ HPLKFTAYDG STAGQDDATL GLDLRTPRGA
60 70 80 90 100
TYLATAPGEL GLARAYVSGD LQAHGVHPGD PYELLKTLTE RVDFKRPSAR
110 120 130 140 150
VLANVVRSIG VEHILPIAPP PQEARPRWRR MANGLLHSKT RDAEAIHHHY
160 170 180 190 200
DVSNNFYEWV LGPSMTYTCA VFPNAEASLE QAQENKYRLI FEKLRLEPGD
210 220 230 240 250
RLLDVGCGWG GMVRYAARRG VRVIGATLSA EQAKWGQKAV EDEGLSDLAQ
260 270 280 290 300
VRHSDYRDVA ETGFDAVSSI GLTEHIGVKN YPFYFGFLKS KLRTGGLLLN
310 320 330 340 350
HCITRHDNRS TSFAGGFTDR YVFPDGELTG SGRITTEIQQ VGLEVLHEEN
360 370 380 390 400
FRHHYAMTLR DWCGNLVEHW DDAVAEVGLP TAKVWGLYMA ASRVAFERNN
410 420
LQLHHVLATK VDPRGDDSLP LRPWWQP
Sequence cautioni
The sequence AFN51741 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.
The sequence AIR16510 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.
The sequence CCP46546 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.
The sequence KBJ24793 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46546.1 Different initiation. CP003248 Genomic DNA Translation: AFN51741.1 Different initiation. JLDD01000048 Genomic DNA Translation: KBJ24793.1 Different initiation. CP009480 Genomic DNA Translation: AIR16510.1 Different initiation. |
RefSeqi | NP_218237.3, NC_000962.3 |
Genome annotation databases
EnsemblBacteriai | AFN51741; AFN51741; RVBD_3720 AIR16510; AIR16510; LH57_20270 CCP46546; CCP46546; Rv3720 KBJ24793; KBJ24793; P425_03869 |
GeneIDi | 885219 |
KEGGi | mtu:Rv3720 mtv:RVBD_3720 |
PATRICi | fig|83332.111.peg.4136 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46546.1 Different initiation. CP003248 Genomic DNA Translation: AFN51741.1 Different initiation. JLDD01000048 Genomic DNA Translation: KBJ24793.1 Different initiation. CP009480 Genomic DNA Translation: AIR16510.1 Different initiation. |
RefSeqi | NP_218237.3, NC_000962.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv3720 |
Proteomic databases
PaxDbi | O69687 |
PRIDEi | O69687 |
Genome annotation databases
EnsemblBacteriai | AFN51741; AFN51741; RVBD_3720 AIR16510; AIR16510; LH57_20270 CCP46546; CCP46546; Rv3720 KBJ24793; KBJ24793; P425_03869 |
GeneIDi | 885219 |
KEGGi | mtu:Rv3720 mtv:RVBD_3720 |
PATRICi | fig|83332.111.peg.4136 |
Organism-specific databases
TubercuListi | Rv3720 |
Phylogenomic databases
eggNOGi | ENOG4105CV9 Bacteria COG2230 LUCA |
HOGENOMi | HOG000245192 |
InParanoidi | O69687 |
KOi | K00574 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-8007-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR003333 Mycolic_cyclopropane_synthase IPR029063 SAM-dependent_MTases |
PIRSFi | PIRSF003085 CMAS, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FAMT_MYCTU | |
Accessioni | O69687Primary (citable) accession number: O69687 Secondary accession number(s): I6X864 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 2015 |
Last sequence update: | April 1, 2015 | |
Last modified: | October 16, 2019 | |
This is version 119 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names