Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Glyceraldehyde 3-phosphateBy similarity1
Active sitei95Proton donorBy similarity1
Metal bindingi96Zinc 1; catalyticBy similarity1
Metal bindingi131Zinc 2By similarity1
Metal bindingi161Zinc 2By similarity1
Metal bindingi212Zinc 1; catalyticBy similarity1
Binding sitei213Dihydroxyacetone phosphate; via amide nitrogenBy similarity1
Metal bindingi252Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-323-MONOMER
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:ML0286
ORF Names:MLCB4.29c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001787211 – 345Fructose-bisphosphate aldolaseAdd BLAST345

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0286

Structurei

3D structure databases

ProteinModelPortaliO69600
SMRiO69600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni253 – 255Dihydroxyacetone phosphate bindingBy similarity3
Regioni274 – 277Dihydroxyacetone phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107RCW Bacteria
COG0191 LUCA
HOGENOMiHOG000227794
KOiK01624
OMAiELCKDCI
OrthoDBiPOG091H01YW

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
IPR006411 Fruct_bisP_bact
PANTHERiPTHR30559 PTHR30559, 1 hit
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit
TIGRFAMsiTIGR00167 cbbA, 1 hit
TIGR01520 FruBisAldo_II_A, 1 hit
PROSITEiView protein in PROSITE
PS00602 ALDOLASE_CLASS_II_1, 1 hit
PS00806 ALDOLASE_CLASS_II_2, 1 hit

Sequencei

Sequence statusi: Complete.

O69600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIATPEIYA EMLRRAKENS YAFPAINCTS SETVNAAIKG FADAGSDGII
60 70 80 90 100
QFSTGGAEFA SGLGVKDMVT GAVALAKFTH TIAAKYPINV ALHTDHCPKD
110 120 130 140 150
KLDSYVRPLL AISARRVATG KDPLFGSHMW DGSAIPIDEN LAIAQDLLKD
160 170 180 190 200
AAAAKIILEV EIGVVGGEED GVAGEINEKL YTTPKDFVKT IDALGAGEHG
210 220 230 240 250
KYLLAATFGN VHGVYKPGNV KLRPDILAEG QKVAAAKLSQ SEGSKPFDFV
260 270 280 290 300
FHGGSGSEKS EIEEALRYGV VKMNVDTDTQ YAFTRPVSGH MFTNYDGVLK
310 320 330 340
VDGDVGNKKV YDPRSYLKKA EASMTERVLE ACNDLRCAGK SVAAS
Length:345
Mass (Da):36,741
Last modified:August 1, 1998 - v1
Checksum:i29FE8474C41D00C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023514 Genomic DNA Translation: CAA18950.1
AL583918 Genomic DNA Translation: CAC29794.1
PIRiF86944
RefSeqiNP_301326.1, NC_002677.1
WP_010907650.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29794; CAC29794; CAC29794
GeneIDi908824
KEGGimle:ML0286
PATRICifig|272631.5.peg.450

Similar proteinsi

Entry informationi

Entry nameiALF_MYCLE
AccessioniPrimary (citable) accession number: O69600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health