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UniProtKB - O69473 (KASB_MYCLE)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
kasB
Organism
Mycobacterium leprae (strain TN)
Status
Functioni
Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the elongation of long chain acyl-ACP substrates by the addition of two carbons from malonyl-ACP to an acyl acceptor. Involved in extension of the mycolate chains to full lengths and produces longer chain multiunsaturated hydrocarbons averaging 54 carbons in length.
By similarityCatalytic activityi
- an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H+ + malonyl-[ACP] = a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]By similarityEC:2.3.1.294By similarityThis reaction proceeds in the forwardBy similarity direction.
: mycolic acid biosynthesis Pathwayi
This protein is involved in the pathway mycolic acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway mycolic acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 173 | By similarity | 1 |
GO - Molecular functioni
- acyltransferase activity Source: UniProtKB-KW
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00915 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.294By similarity)Alternative name(s): Beta-ketoacyl-ACP synthase 2 Short name: KAS 2 |
Gene namesi | Name:kasB Ordered Locus Names:ML1656 ORF Names:MLCB1243.19c |
Organismi | Mycobacterium leprae (strain TN) |
Taxonomic identifieri | 272631 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › |
Proteomesi |
|
Organism-specific databases
Lepromai | ML1656 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180332 | 1 – 420 | 3-oxoacyl-[acyl-carrier-protein] synthase 2Add BLAST | 420 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_11 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
i Sequence
Sequence statusi: Complete.
O69473-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTSPELVTG KAFPNVVVTG IAMTTALATD AETTWKLLLD NQSGIRMLDD
60 70 80 90 100
PFIEEFNLPV RIGGHLLEEF DHQLTRVELR RMGYLQRMST VLSRRLWENA
110 120 130 140 150
GSPEVDTNRL MVSIGTGLGS AEELVFSYDD MRARGMKAVS PLAVQKYMPN
160 170 180 190 200
GAAAAVGLEH HAKAGVMTPV SACASGSEAI AHAWQQIVLG EADSAICGGV
210 220 230 240 250
ETKIEAVPIA GFSQMRIVMS TKNDNPAGAC RPFDRDRDGF VFGEAGALML
260 270 280 290 300
IETEDSAKAR SANILARIMG ASITSDGFHM VAPDPNGERA GHAIARAVHL
310 320 330 340 350
AGLSPSDIDH VNAHATGTQV GDLAEAKAIN KALCNNRPAV YAPKSALGHS
360 370 380 390 400
VGAVGAVESI LTVLALRDQV IPPTLNLVNL DPDIDLDVVA GKPRPGDYRY
410 420
AVNNSFGFGG HNVAIAFGCY
Sequence cautioni
The sequence CAA19200 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC30607 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL023635 Genomic DNA Translation: CAA19200.1 Different initiation. AL583922 Genomic DNA Translation: CAC30607.1 Different initiation. |
PIRi | T44710 |
RefSeqi | WP_010908458.1, NC_002677.1 |
Genome annotation databases
EnsemblBacteriai | CAC30607; CAC30607; CAC30607 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL023635 Genomic DNA Translation: CAA19200.1 Different initiation. AL583922 Genomic DNA Translation: CAC30607.1 Different initiation. |
PIRi | T44710 |
RefSeqi | WP_010908458.1, NC_002677.1 |
3D structure databases
SMRi | O69473 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272631.ML1656 |
Genome annotation databases
EnsemblBacteriai | CAC30607; CAC30607; CAC30607 |
Organism-specific databases
Lepromai | ML1656 |
Phylogenomic databases
eggNOGi | COG0304, Bacteria |
HOGENOMi | CLU_000022_69_2_11 |
Enzyme and pathway databases
UniPathwayi | UPA00915 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KASB_MYCLE | |
Accessioni | O69473Primary (citable) accession number: O69473 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 14, 2001 |
Last sequence update: | August 14, 2001 | |
Last modified: | September 29, 2021 | |
This is version 113 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families