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Protein

60 kDa chaperonin

Gene

groL

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-1178-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:Cj1221
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633221 – 54560 kDa chaperoninAdd BLAST545

Proteomic databases

PaxDbiO69289
PRIDEiO69289

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

IntActiO69289, 97 interactors
STRINGi192222.Cj1221

Structurei

3D structure databases

ProteinModelPortaliO69289
SMRiO69289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA
HOGENOMiHOG000076290
KOiK04077
OMAiTDTDKME

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

O69289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIIFSDE ARNKLYEGVK KLNDAVKVTM GPRGRNVLIQ KSFGAPSITK
60 70 80 90 100
DGVSVAKEVE LKDSLENMGA SLVREVASKT ADQAGDGTTT ATVLAHAIFK
110 120 130 140 150
EGLRNITAGA NPIEVKRGMD KACEAIVAEL KKLSREVKDK KEIAQVATIS
160 170 180 190 200
ANSDEKIGNL IADAMEKVGK DGVITVEEAK SINDELNVVE GMQFDRGYLS
210 220 230 240 250
PYFITNAEKM TVELSSPYIL LFDKKITNLK DLLPVLEQIQ KTGKPLLIIA
260 270 280 290 300
EDIEGEALAT LVVNKLRGVL NISAVKAPGF GDRRKAMLED IAILTGGEVI
310 320 330 340 350
SEELGRTLES ATIQDLGQAS SVIIDKDNTT IVNGAGEKAN IDARVNQIKA
360 370 380 390 400
QIAETTSDYD REKLQERLAK LSGGVAVIKV GAATETEMKE KKDRVDDALS
410 420 430 440 450
ATKAAVEEGI VIGGGAALIK AKAKIKLDLQ GDEAIGAAIV ERALRAPLRQ
460 470 480 490 500
IAENAGFDAG VVVNSVENAK DENTGFDAAK GEYVNMLESG IIDPVKVERV
510 520 530 540
ALLNAVSVAS MLLTTEATIS EIKEDKPTMP DMSGMGGMGG MGGMM
Length:545
Mass (Da):57,971
Last modified:December 1, 2000 - v2
Checksum:i4DA80BC64330C41E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179A → P in CAA73778 (PubMed:10206714).Curated1
Sequence conflicti383A → T in CAA73778 (PubMed:10206714).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13334 Genomic DNA Translation: CAA73778.1
AF461064 Genomic DNA Translation: AAL76936.1
AF461534 Genomic DNA Translation: AAL67841.1
AF461535 Genomic DNA Translation: AAL67842.1
AF461537 Genomic DNA Translation: AAL67844.1
AL111168 Genomic DNA Translation: CAL35336.1
PIRiG81328
RefSeqiWP_002858047.1, NC_002163.1
YP_002344612.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL35336; CAL35336; Cj1221
GeneIDi905511
KEGGicje:Cj1221
PATRICifig|192222.6.peg.1203

Similar proteinsi

Entry informationi

Entry nameiCH60_CAMJE
AccessioniPrimary (citable) accession number: O69289
Secondary accession number(s): Q0P935, Q9PN75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: July 18, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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