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UniProtKB - O69203 (DCDA_ACTPA)
Protein
Diaminopimelate decarboxylase
Gene
lysA
Organism
Actinosynnema pretiosum subsp. auranticum
Status
Functioni
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
UniRule annotationCatalytic activityi
- EC:4.1.1.20UniRule annotation
Cofactori
pyridoxal 5'-phosphateUniRule annotation
: L-lysine biosynthesis via DAP pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-lysine from DL-2,6-diaminopimelate.UniRule annotation This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from DL-2,6-diaminopimelate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 256 | Pyridoxal phosphate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 301 | SubstrateUniRule annotation | 1 | |
Binding sitei | 337 | SubstrateUniRule annotation | 1 | |
Binding sitei | 341 | SubstrateUniRule annotation | 1 | |
Active sitei | 366 | Proton donorSequence analysis | 1 | |
Binding sitei | 367 | SubstrateUniRule annotation | 1 | |
Binding sitei | 396 | Pyridoxal phosphateUniRule annotation | 1 | |
Binding sitei | 396 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- diaminopimelate decarboxylase activity Source: UniProtKB-UniRule
- pyridoxal phosphate binding Source: UniProtKB-UniRule
GO - Biological processi
- lysine biosynthetic process via diaminopimelate Source: UniProtKB-UniRule
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Amino-acid biosynthesis, Lysine biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
UniPathwayi | UPA00034;UER00027 |
Names & Taxonomyi
Protein namesi | Recommended name: Diaminopimelate decarboxylaseUniRule annotation (EC:4.1.1.20UniRule annotation)Short name: DAP decarboxylaseUniRule annotation Short name: DAPDCUniRule annotation |
Gene namesi | Name:lysAUniRule annotation |
Organismi | Actinosynnema pretiosum subsp. auranticum |
Taxonomic identifieri | 42198 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Pseudonocardiales › Pseudonocardiaceae › Actinosynnema › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149911 | 1 – 437 | Diaminopimelate decarboxylaseAdd BLAST | 437 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 81 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 298 – 301 | Pyridoxal phosphate bindingUniRule annotation | 4 |
Sequence similaritiesi
Family and domain databases
CDDi | cd06828, PLPDE_III_DapDC, 1 hit |
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_02120, LysA, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR002986, DAP_deCOOHase_LysA IPR022643, De-COase2_C IPR022644, De-COase2_N IPR000183, Orn/DAP/Arg_de-COase IPR029066, PLP-binding_barrel |
Pfami | View protein in Pfam PF02784, Orn_Arg_deC_N, 1 hit PF00278, Orn_DAP_Arg_deC, 1 hit |
PRINTSi | PR01181, DAPDCRBXLASE PR01179, ODADCRBXLASE |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR01048, lysA, 1 hit |
i Sequence
Sequence statusi: Complete.
O69203-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLAELLPSV GMTGEPALET GLWPLGTRLE RGELLLGGVP ATELAARFGT
60 70 80 90 100
PCQVLDEGTV RARARAFREA LPEAEVVFAG KALPCREVYR WVADEGLSLD
110 120 130 140 150
VCSAGELAIA RSVGFPAERV LLHGNVKTPE DLKAALGYGV GRVVVDSFDE
160 170 180 190 200
IEQLGALAEG PQDVLVRVTP GVDPRTHRAV ATGVEDQKFG FSLAGGDALE
210 220 230 240 250
AVLRVVEQPS LRLVGLHCHV GSQVRHVAVY EEAARRVVGL IASCGVRIEQ
260 270 280 290 300
LDLGGGFAVP YLPGEGEFDL GGFAHRVRVA LSHECALRRV PVPRLSIEPG
310 320 330 340 350
RAVVARAGVT LYRVAAVKRG VRRVFVAVDG GMSDNPRPAL YGSRYAVRLV
360 370 380 390 400
RRGGRRAPVT VVGRHCEAGD VLAEDVPLPE DVRAGDLLAV PVTGAYHHAL
410 420 430
ASNYNAVGRP PVVGVRDGVA RVLVRRETEE DLLRREV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33059 Genomic DNA Translation: AAC13998.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U33059 Genomic DNA Translation: AAC13998.1 |
3D structure databases
SMRi | O69203 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00034;UER00027 |
Family and domain databases
CDDi | cd06828, PLPDE_III_DapDC, 1 hit |
Gene3Di | 2.40.37.10, 1 hit 3.20.20.10, 1 hit |
HAMAPi | MF_02120, LysA, 1 hit |
InterProi | View protein in InterPro IPR009006, Ala_racemase/Decarboxylase_C IPR002986, DAP_deCOOHase_LysA IPR022643, De-COase2_C IPR022644, De-COase2_N IPR000183, Orn/DAP/Arg_de-COase IPR029066, PLP-binding_barrel |
Pfami | View protein in Pfam PF02784, Orn_Arg_deC_N, 1 hit PF00278, Orn_DAP_Arg_deC, 1 hit |
PRINTSi | PR01181, DAPDCRBXLASE PR01179, ODADCRBXLASE |
SUPFAMi | SSF50621, SSF50621, 1 hit SSF51419, SSF51419, 1 hit |
TIGRFAMsi | TIGR01048, lysA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DCDA_ACTPA | |
Accessioni | O69203Primary (citable) accession number: O69203 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | October 7, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families