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Entry version 137 (17 Jun 2020)
Sequence version 1 (01 Aug 1998)
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Protein
Submitted name:

Biliverdin-producing heme oxygenase

Gene

pigA

Organism
Pseudomonas aeruginosa
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-20092

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.99.3 5087

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Biliverdin-producing heme oxygenaseImported
Submitted name:
Heme oxygenaseImported
Submitted name:
Iron-starvation protein PigAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pigAImported
Synonyms:hemOImported
ORF Names:ALP65_00426Imported, CAZ10_13305Imported, CGU42_23080Imported, DT376_10645Imported, DY930_29755Imported, ECC04_025850Imported, F6X67_26445Imported, F7O92_30530Imported, F7O96_31670Imported, FDK04_24020Imported, FEM29_30630Imported, FZE40_32540Imported, FZE44_12750Imported, FZE49_32405Imported, GEZ68_27135Imported, GNQ12_06290Imported, GNQ36_22825Imported, GNQ40_32500Imported, GNQ48_32025Imported, GNQ66_16100Imported, GRH68_29375Imported, GRH69_21820Imported, GRH78_22455Imported, IPC116_22530Imported, IPC1481_27455Imported, IPC1509_31760Imported, IPC36_08605Imported, IPC584_20070Imported, IPC669_28505Imported, NCTC10299_05739Imported, NCTC11839_00185Imported, NCTC12951_06379Imported, PaeAG1_05105Imported, PAMH19_3887Imported, RW109_RW109_05557Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000043988 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000297623 Componenti: Unassembled WGS sequence
  • UP000341742 Componenti: Unassembled WGS sequence
  • UP000253594 Componenti: Unassembled WGS sequence
  • UP000434824 Componenti: Unassembled WGS sequence
  • UP000437641 Componenti: Unassembled WGS sequence
  • UP000272646 Componenti: Unassembled WGS sequence
  • UP000429867 Componenti: Unassembled WGS sequence
  • UP000270834 Componenti: Unassembled WGS sequence
  • UP000194857 Componenti: Unassembled WGS sequence
  • UP000435158 Componenti: Unassembled WGS sequence
  • UP000436576 Componenti: Unassembled WGS sequence
  • UP000370342 Componenti: Unassembled WGS sequence
  • UP000297560 Componenti: Unassembled WGS sequence
  • UP000357073 Componenti: Unassembled WGS sequence
  • UP000434675 Componenti: Unassembled WGS sequence
  • UP000436725 Componenti: Unassembled WGS sequence
  • UP000436072 Componenti: Unassembled WGS sequence
  • UP000305227 Componenti: Unassembled WGS sequence
  • UP000233777 Componenti: Chromosome mainomosome
  • UP000433583 Componenti: Unassembled WGS sequence
  • UP000351144 Componenti: Chromosome
  • UP000278438 Componenti: Unassembled WGS sequence
  • UP000341211 Componenti: Unassembled WGS sequence
  • UP000432526 Componenti: Unassembled WGS sequence
  • UP000297232 Componenti: Unassembled WGS sequence
  • UP000441387 Componenti: Unassembled WGS sequence
  • UP000424265 Componenti: Chromosome
  • UP000433532 Componenti: Unassembled WGS sequence
  • UP000433154 Componenti: Unassembled WGS sequence
  • UP000297494 Componenti: Unassembled WGS sequence
  • UP000297376 Componenti: Unassembled WGS sequence
  • UP000285404 Componenti: Unassembled WGS sequence
  • UP000441928 Componenti: Unassembled WGS sequence
  • UP000216659 Componenti: Unassembled WGS sequence

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA0672

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075209

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
287.DR97_1447

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108YNN Bacteria
COG3230 LUCA

KEGG Orthology (KO)

More...
KOi
K07215

Database of Orthologous Groups

More...
OrthoDBi
1608763at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.910.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01126 Heme_oxygenase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48613 SSF48613, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O69002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTLAPESTR QNLRSQRLNL LTNEPHQRLE SLVKSKEPFA SRDNFARFVA
60 70 80 90 100
AQYLFQHDLE PLYRNEALAR LFPGLASRAR DDAARADLAD LGHPVPEGDQ
110 120 130 140 150
SVREADLSLA EALGWLFVSE GSKLGAAFLF KKAAALELDE NFGARHLAEP
160 170 180 190
EGGRAQGWKS FVAILDGIEL NEEEERLAAK GASDAFNRFG DLLERTFA
Length:198
Mass (Da):21,954
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4308A9BE04B03B95
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF060193 Genomic DNA Translation: AAC15188.1
CDAZ01000013 Genomic DNA Translation: CEI17032.1
VZIK01000108 Genomic DNA Translation: KAB0688095.1
VZIJ01000151 Genomic DNA Translation: KAB0690542.1
VZIU01000145 Genomic DNA Translation: KAB0744360.1
WHVM01000043 Genomic DNA Translation: MQH08157.1
WOAK01000077 Genomic DNA Translation: MUH94534.1
WOAE01000015 Genomic DNA Translation: MUI26893.1
WOAD01000074 Genomic DNA Translation: MUI39605.1
WOAQ01000008 Genomic DNA Translation: MUI76131.1
WOAV01000002 Genomic DNA Translation: MUJ05067.1
VTFC01000082 Genomic DNA Translation: MWB67193.1
VTFB01000077 Genomic DNA Translation: MWB86177.1
VTFD01000010 Genomic DNA Translation: MWB88836.1
WUDL01000051 Genomic DNA Translation: MWV94306.1
WUDC01000056 Genomic DNA Translation: MWW39862.1
WUDM01000130 Genomic DNA Translation: MWW73915.1
NFFZ01000005 Genomic DNA Translation: OTI62534.1
NMRQ01000049 Genomic DNA Translation: OZO15116.1
CP045739 Genomic DNA Translation: QGH93281.1
CP039990 Genomic DNA Translation: QGQ05518.1
QORE01000276 Genomic DNA Translation: RCI74876.1
RBSQ01000583 Genomic DNA Translation: RMS55377.1
NSVB01000019 Genomic DNA Translation: RPY65319.1
RXTB01000151 Genomic DNA Translation: RTR67156.1
LT969520 Genomic DNA Translation: SOV31427.1
RWMJ01000025 Genomic DNA Translation: TEE12222.1
RWNG01000022 Genomic DNA Translation: TEF39295.1
RWQO01000005 Genomic DNA Translation: TEK64536.1
RWTJ01000009 Genomic DNA Translation: TEO90110.1
RWUZ01000002 Genomic DNA Translation: TER57343.1
RHMD02000002 Genomic DNA Translation: TGB22664.1
VAVP01000068 Genomic DNA Translation: TLJ61210.1
CAADJQ010000024 Genomic DNA Translation: VFT47726.1
CABEEV010000003 Genomic DNA Translation: VTQ73975.1
CABEES010000098 Genomic DNA Translation: VTQ98744.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A83562

NCBI Reference Sequences

More...
RefSeqi
NP_249363.1, NC_002516.2
WP_003085321.1, NZ_WOVI01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CEI17032; CEI17032; PAMH19_3887
CRP97101; CRP97101; PAERUG_P32_London_17_VIM_2_10_11_05923
CRQ70367; CRQ70367; PAERUG_E15_London_28_01_14_05038

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
880820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA0672
paeb:NCGM1900_2097

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|287.1477.peg.5177

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060193 Genomic DNA Translation: AAC15188.1
CDAZ01000013 Genomic DNA Translation: CEI17032.1
VZIK01000108 Genomic DNA Translation: KAB0688095.1
VZIJ01000151 Genomic DNA Translation: KAB0690542.1
VZIU01000145 Genomic DNA Translation: KAB0744360.1
WHVM01000043 Genomic DNA Translation: MQH08157.1
WOAK01000077 Genomic DNA Translation: MUH94534.1
WOAE01000015 Genomic DNA Translation: MUI26893.1
WOAD01000074 Genomic DNA Translation: MUI39605.1
WOAQ01000008 Genomic DNA Translation: MUI76131.1
WOAV01000002 Genomic DNA Translation: MUJ05067.1
VTFC01000082 Genomic DNA Translation: MWB67193.1
VTFB01000077 Genomic DNA Translation: MWB86177.1
VTFD01000010 Genomic DNA Translation: MWB88836.1
WUDL01000051 Genomic DNA Translation: MWV94306.1
WUDC01000056 Genomic DNA Translation: MWW39862.1
WUDM01000130 Genomic DNA Translation: MWW73915.1
NFFZ01000005 Genomic DNA Translation: OTI62534.1
NMRQ01000049 Genomic DNA Translation: OZO15116.1
CP045739 Genomic DNA Translation: QGH93281.1
CP039990 Genomic DNA Translation: QGQ05518.1
QORE01000276 Genomic DNA Translation: RCI74876.1
RBSQ01000583 Genomic DNA Translation: RMS55377.1
NSVB01000019 Genomic DNA Translation: RPY65319.1
RXTB01000151 Genomic DNA Translation: RTR67156.1
LT969520 Genomic DNA Translation: SOV31427.1
RWMJ01000025 Genomic DNA Translation: TEE12222.1
RWNG01000022 Genomic DNA Translation: TEF39295.1
RWQO01000005 Genomic DNA Translation: TEK64536.1
RWTJ01000009 Genomic DNA Translation: TEO90110.1
RWUZ01000002 Genomic DNA Translation: TER57343.1
RHMD02000002 Genomic DNA Translation: TGB22664.1
VAVP01000068 Genomic DNA Translation: TLJ61210.1
CAADJQ010000024 Genomic DNA Translation: VFT47726.1
CABEEV010000003 Genomic DNA Translation: VTQ73975.1
CABEES010000098 Genomic DNA Translation: VTQ98744.1
PIRiA83562
RefSeqiNP_249363.1, NC_002516.2
WP_003085321.1, NZ_WOVI01000009.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SK7X-ray1.60A1-198[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi287.DR97_1447

Chemistry databases

ChEMBLiCHEMBL1075209

Genome annotation databases

EnsemblBacteriaiCEI17032; CEI17032; PAMH19_3887
CRP97101; CRP97101; PAERUG_P32_London_17_VIM_2_10_11_05923
CRQ70367; CRQ70367; PAERUG_E15_London_28_01_14_05038
GeneIDi880820
KEGGipae:PA0672
paeb:NCGM1900_2097
PATRICifig|287.1477.peg.5177

Organism-specific databases

PseudoCAPiPA0672

Phylogenomic databases

eggNOGiENOG4108YNN Bacteria
COG3230 LUCA
KOiK07215
OrthoDBi1608763at2

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20092
BRENDAi1.14.99.3 5087

Family and domain databases

Gene3Di1.20.910.10, 1 hit
InterProiView protein in InterPro
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
SUPFAMiSSF48613 SSF48613, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO69002_PSEAI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O69002
Secondary accession number(s): Q7DCI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 17, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
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