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Protein

Copper-containing nitrite reductase

Gene

nir

Organism
Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.UniRule annotation

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi32Zinc 1; via tele nitrogenCombined sources1
Metal bindingi94Zinc 2; via pros nitrogenCombined sources1
Metal bindingi97Zinc 2Combined sources1
Metal bindingi97Zinc 3Combined sources1
Metal bindingi113Copper 1; via pros nitrogenCombined sources1
Metal bindingi118Copper 2; via tele nitrogenCombined sources1
Metal bindingi118Copper 3; via tele nitrogenCombined sources1
Metal bindingi118Zinc 4; via tele nitrogenCombined sources1
Metal bindingi153Copper 2; via tele nitrogenCombined sources1
Metal bindingi153Zinc 4; via tele nitrogenCombined sources1
Metal bindingi154Copper 1Combined sources1
Metal bindingi163Copper 1; via pros nitrogenCombined sources1
Metal bindingi168Copper 1Combined sources1
Metal bindingi189Zinc 5; via tele nitrogenCombined sources1
Metal bindingi189Zinc 6; via tele nitrogenCombined sources1
Metal bindingi191Zinc 5Combined sources1
Metal bindingi191Zinc 6Combined sources1
Metal bindingi219Zinc 2Combined sources1
Metal bindingi219Zinc 3Combined sources1
Metal bindingi219Zinc 5Combined sources1
Metal bindingi219Zinc 7Combined sources1
Metal bindingi324Copper 1; via tele nitrogenCombined sources1
Metal bindingi324Copper 2; via tele nitrogenCombined sources1
Metal bindingi324Copper 3; via tele nitrogenCombined sources1
Metal bindingi324Zinc 4; via tele nitrogenCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandCopperUniRule annotationCombined sources, Metal-bindingUniRule annotationCombined sources, ZincCombined sources

Enzyme and pathway databases

BRENDAi1.7.2.1 238

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-containing nitrite reductaseUniRule annotation (EC:1.7.2.1UniRule annotation)
Gene namesi
Name:nirImported
Synonyms:nirKImported
ORF Names:CE206_10515Imported, ERS451415_02178Imported
OrganismiAlcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans)Imported
Taxonomic identifieri85698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeAchromobacter
Proteomesi
  • UP000059657 Componenti: Chromosome 1
  • UP000250733 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03088 Pidolic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501509680025 – 360Copper-containing nitrite reductaseUniRule annotationAdd BLAST336

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

DIPiDIP-59300N
IntActiO68601, 1 interactor

Structurei

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 177Plastocyanin-likeInterPro annotationAdd BLAST109
Domaini193 – 344Plastocyanin-likeInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the multicopper oxidase family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEI Bacteria
COG2132 LUCA
KOiK00368

Family and domain databases

Gene3Di2.60.40.420, 2 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011707 Cu-oxidase_3
IPR008972 Cupredoxin
IPR001287 NO2-reductase_Cu
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07732 Cu-oxidase_3, 1 hit
PRINTSiPR00695 CUNO2RDTASE
SUPFAMiSSF49503 SSF49503, 2 hits
TIGRFAMsiTIGR02376 Cu_nitrite_red, 1 hit

Sequencei

Sequence statusi: Complete.

O68601-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNALRPTLLA AALAFTMAAG TAWAQDADKL PHTKVTLVAP PQVHPHEQAT
60 70 80 90 100
KSGPKVVEFT MTIEEKKMVI DDKGTTLQAM TFNGSMPGPT LVVHEGDYVQ
110 120 130 140 150
LTLVNPATNA MPHNVDFHGA TGALGGAKLT NVNPGEQATL RFKADRSGTF
160 170 180 190 200
VYHCAPEGMV PWHVVSGMSG TLMVLPRDGL KDPQGKPLHY DRAYTIGEFD
210 220 230 240 250
LYIPKGPDGK YKDYATLAES YGDTVQVMRT LTPSHIVFNG KVGALTGANA
260 270 280 290 300
LTAKVGETVL LIHSQANRDT RPHLIGGHGD WVWETGKFAN PPQRDLETWF
310 320 330 340 350
IRGGSAGAAL YTFKQPGVYA YLNHNLIEAF ELGAAGHIKV EGKWNDDLMK
360
QIKAPAPIPR
Length:360
Mass (Da):38,939
Last modified:August 1, 1998 - v1
Checksum:i3748B5BD3BFF44E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051831 Genomic DNA Translation: AAC05831.1
CP025774 Genomic DNA Translation: AXA76856.1
AB013078 Genomic DNA Translation: BAA33678.1
LN831029 Genomic DNA Translation: CKH22667.1
PIRiJE0215
JG0170
RefSeqiWP_006384283.1, NZ_QENE01000019.1

Genome annotation databases

EnsemblBacteriaiCKH22667; CKH22667; ERS451415_02178
GeneIDi29505457
KEGGiaxx:ERS451415_02178
PATRICifig|85698.28.peg.2185

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051831 Genomic DNA Translation: AAC05831.1
CP025774 Genomic DNA Translation: AXA76856.1
AB013078 Genomic DNA Translation: BAA33678.1
LN831029 Genomic DNA Translation: CKH22667.1
PIRiJE0215
JG0170
RefSeqiWP_006384283.1, NZ_QENE01000019.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BQ5X-ray2.05A19-360[»]
1GS6X-ray2.20X25-360[»]
1GS7X-ray1.85A25-360[»]
1GS8X-ray1.90A25-360[»]
1HAUX-ray1.90A25-360[»]
1HAWX-ray1.90A25-360[»]
1NDTX-ray2.10A26-359[»]
1OE1X-ray1.04A25-360[»]
1OE2X-ray1.12A25-360[»]
1OE3X-ray1.15A25-360[»]
1WA0X-ray1.60X25-360[»]
1WA1X-ray1.65X25-360[»]
1WA2X-ray1.72X25-360[»]
1WAEX-ray1.95A25-360[»]
2BO0X-ray1.35A25-360[»]
2BP0X-ray1.90A/B25-360[»]
2BP8X-ray1.90A/B25-360[»]
2JFCX-ray2.40A/B/C/D/E/F26-360[»]
2VM3X-ray1.80A25-360[»]
2VM4X-ray1.90A25-360[»]
2VMJX-ray2.50A25-360[»]
2VN3X-ray2.35A25-360[»]
2VW4X-ray1.90A/B25-360[»]
2VW6X-ray1.90A/B25-360[»]
2VW7X-ray1.90A/B25-360[»]
2XWZX-ray2.34A/B/C/D/E/F26-360[»]
2XX0X-ray1.46A/B26-360[»]
2XX1X-ray3.00A/B/C/D/E/F26-360[»]
2XXFX-ray1.50A/B26-360[»]
2XXGX-ray1.60A/C25-360[»]
2ZONX-ray1.70A/B/C25-360[»]
4CSPX-ray1.70A/F26-360[»]
4CSZX-ray1.75A26-360[»]
5B1JX-ray3.00A/B25-360[»]
5B1KX-ray1.35A25-360[»]
5ONXX-ray1.60A26-360[»]
5ONYX-ray1.60A26-360[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59300N
IntActiO68601, 1 interactor

Chemistry databases

DrugBankiDB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03088 Pidolic Acid

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCKH22667; CKH22667; ERS451415_02178
GeneIDi29505457
KEGGiaxx:ERS451415_02178
PATRICifig|85698.28.peg.2185

Phylogenomic databases

eggNOGiENOG4105CEI Bacteria
COG2132 LUCA
KOiK00368

Enzyme and pathway databases

BRENDAi1.7.2.1 238

Family and domain databases

Gene3Di2.60.40.420, 2 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011707 Cu-oxidase_3
IPR008972 Cupredoxin
IPR001287 NO2-reductase_Cu
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07732 Cu-oxidase_3, 1 hit
PRINTSiPR00695 CUNO2RDTASE
SUPFAMiSSF49503 SSF49503, 2 hits
TIGRFAMsiTIGR02376 Cu_nitrite_red, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO68601_ALCXX
AccessioniPrimary (citable) accession number: O68601
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 10, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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