UniProtKB - O68586 (LANN_STRMG)
Protein
Lantibiotic mutacin-1140
Gene
lanA
Organism
Streptococcus mutans
Status
Functioni
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
GO - Molecular functioni
- signaling receptor binding Source: UniProtKB-KW
GO - Biological processi
- cytolysis Source: UniProtKB-KW
- defense response to bacterium Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Bacteriocin, Lantibiotic |
Protein family/group databases
TCDBi | 1.C.20.1.8, the nisin (nisin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Lantibiotic mutacin-1140Alternative name(s): Mutacin III |
Gene namesi | Name:lanA Synonyms:mutA |
Organismi | Streptococcus mutans |
Taxonomic identifieri | 1309 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000017130 | 1 – 41 | 1 PublicationAdd BLAST | 41 | |
PeptideiPRO_0000017131 | 42 – 63 | Lantibiotic mutacin-1140Add BLAST | 22 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 44 ↔ 48 | Lanthionine (Ser-Cys)1 Publication | ||
Modified residuei | 46 | 2,3-didehydroalanine (Ser)1 Publication | 1 | |
Cross-linki | 49 ↔ 52 | Beta-methyllanthionine (Thr-Cys)1 Publication | ||
Modified residuei | 55 | 2,3-didehydrobutyrine1 Publication | 1 | |
Cross-linki | 57 ↔ 62 | Lanthionine (Ser-Cys)1 Publication | ||
Cross-linki | 60 ↔ 63 | S-(2-aminovinyl)-D-cysteine (Ser-Cys)1 Publication |
Post-translational modificationi
Maturation of lantibiotics involves the enzymatic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. The C-terminal lanthionine undergoes decarboxylation. This is followed by membrane translocation and cleavage of the modified precursor.
The structure of the 2,3-didehydrobutyrine is not discussed in PubMed:11082191.
Keywords - PTMi
D-amino acid, Thioether bondFamily & Domainsi
Sequence similaritiesi
Belongs to the type A lantibiotic family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR006079, Lantibiotic_typ-A_Bacillales |
Pfami | View protein in Pfam PF02052, Gallidermin, 1 hit |
PRINTSi | PR00323, GALLIDERMIN |
TIGRFAMsi | TIGR03731, lantibio_gallid, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O68586-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNTQLLEVL GTETFDVQED LFAFDTTDTT IVASNDDPDT RFKSWSLCTP
60
GCARTGSFNS YCC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF051560 Genomic DNA Translation: AAC18827.1 AF154675 Genomic DNA Translation: AAD56142.1 |
RefSeqi | WP_002268802.1, NZ_LTAK01000001.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF051560 Genomic DNA Translation: AAC18827.1 AF154675 Genomic DNA Translation: AAD56142.1 |
RefSeqi | WP_002268802.1, NZ_LTAK01000001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
TCDBi | 1.C.20.1.8, the nisin (nisin) family |
Family and domain databases
InterProi | View protein in InterPro IPR006079, Lantibiotic_typ-A_Bacillales |
Pfami | View protein in Pfam PF02052, Gallidermin, 1 hit |
PRINTSi | PR00323, GALLIDERMIN |
TIGRFAMsi | TIGR03731, lantibio_gallid, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LANN_STRMG | |
Accessioni | O68586Primary (citable) accession number: O68586 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families