UniProtKB - O68282 (G6PD_PSEAE)
Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Can utilize either NADP+ or NAD+.UniRule annotation1 Publication
Catalytic activityi
Kineticsi
- KM=530 µM for glucose 6-phosphate (with NADP)1 Publication
- KM=57 µM for NADP1 Publication
- KM=333 µM for NAD1 Publication
: pentose phosphate pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
- 6-phosphogluconolactonase (pgl)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 49 | NADPUniRule annotation | 1 | |
Binding sitei | 145 | NADPUniRule annotation | 1 | |
Binding sitei | 175 | SubstrateUniRule annotation | 1 | |
Binding sitei | 179 | SubstrateUniRule annotation | 1 | |
Binding sitei | 213 | SubstrateUniRule annotation | 1 | |
Binding sitei | 232 | SubstrateUniRule annotation | 1 | |
Active sitei | 237 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 337 | SubstrateUniRule annotation | 1 | |
Binding sitei | 342 | SubstrateUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 92 – 93 | NADPUniRule annotation | 2 |
GO - Molecular functioni
- glucose-6-phosphate dehydrogenase activity Source: UniProtKB-UniRule
- NADP binding Source: UniProtKB-UniRule
GO - Biological processi
- glucose metabolic process Source: UniProtKB-KW
- pentose-phosphate shunt Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Ligand | NAD, NADP |
Enzyme and pathway databases
BioCyci | PAER208964:G1FZ6-3243-MONOMER |
SABIO-RKi | O68282 |
UniPathwayi | UPA00115;UER00408 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.3631 Publication)Short name: G6PDUniRule annotation Alternative name(s): Glucose-6-phosphate dehydrogenase (NAD(P)(+))Curated |
Gene namesi | Name:zwfUniRule annotation Ordered Locus Names:PA3183 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA3183 |
Pathology & Biotechi
Disruption phenotypei
Mutant is unable to grow on minimal medium supplemented with mannitol and shows increased sensitivity to the redox-active superoxide-generating agent methyl viologen (paraquat).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068131 | 1 – 489 | Glucose-6-phosphate 1-dehydrogenaseAdd BLAST | 489 |
Proteomic databases
PaxDbi | O68282 |
PRIDEi | O68282 |
Expressioni
Inductioni
Transcription is maximal during early logarithmic phase when inducing substrates such as glycerol, glucose or gluconate are abundant. Transcription decreases during stationary phase.1 Publication
Interactioni
Subunit structurei
Homotetramer.
1 PublicationFamily & Domainsi
Sequence similaritiesi
Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_013524_5_0_6 |
InParanoidi | O68282 |
OMAi | VEICVYE |
PhylomeDBi | O68282 |
Family and domain databases
HAMAPi | MF_00966, G6PD, 1 hit |
InterProi | View protein in InterPro IPR001282, G6P_DH IPR019796, G6P_DH_AS IPR022675, G6P_DH_C IPR022674, G6P_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR23429, PTHR23429, 1 hit |
Pfami | View protein in Pfam PF02781, G6PD_C, 1 hit PF00479, G6PD_N, 1 hit |
PIRSFi | PIRSF000110, G6PD, 1 hit |
PRINTSi | PR00079, G6PDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00871, zwf, 1 hit |
PROSITEi | View protein in PROSITE PS00069, G6P_DEHYDROGENASE, 1 hit |
i Sequence
Sequence statusi: Complete.
O68282-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDVRVLPCT LALFGALGDL ALRKLFPALY QLDRENLLHR DTRVLALARD
60 70 80 90 100
EGAPAEHLAT LEQRLRLAVP AKEWDDVVWQ RFRERLDYLS MDFLDPQAYV
110 120 130 140 150
GLREAVDDEL PLVAYFATPA SVFGGICENL AAAGLAERTR VVLEKPIGHD
160 170 180 190 200
LESSREVNEA VARFFPESRI YRIDHYLGKE TVQNLIALRF ANSLFETQWN
210 220 230 240 250
QNHISHVEIT VAEKVGIEGR WGYFDQAGQL RDMVQNHLLQ LLCLIAMDPP
260 270 280 290 300
SDLSADSIRD EKVKVLRALE PIPAEQLASR VVRGQYTAGF SDGKAVPGYL
310 320 330 340 350
EEEHANRDSD AETFVALRVD IRNWRWSGVP FYLRTGKRMP QKLSQIVIHF
360 370 380 390 400
KEPPHYIFAP EQRSLISNRL IIRLQPDEGI SLQVMTKDQG LGKGMQLRTG
410 420 430 440 450
PLQLSFSETY HAARIPDAYE RLLLEVTQGN QYLFVRKDEV EFAWKWCDQL
460 470 480
IAGWERLSEA PKPYPAGSWG PVASVALVAR DGRSWYGDF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029673 Genomic DNA Translation: AAC38311.1 AE004091 Genomic DNA Translation: AAG06571.1 |
PIRi | A83248 |
RefSeqi | NP_251873.1, NC_002516.2 WP_003113442.1, NZ_QZGE01000023.1 |
Genome annotation databases
EnsemblBacteriai | AAG06571; AAG06571; PA3183 |
GeneIDi | 882681 |
KEGGi | pae:PA3183 |
PATRICi | fig|208964.12.peg.3327 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029673 Genomic DNA Translation: AAC38311.1 AE004091 Genomic DNA Translation: AAG06571.1 |
PIRi | A83248 |
RefSeqi | NP_251873.1, NC_002516.2 WP_003113442.1, NZ_QZGE01000023.1 |
3D structure databases
SMRi | O68282 |
ModBasei | Search... |
Proteomic databases
PaxDbi | O68282 |
PRIDEi | O68282 |
Genome annotation databases
EnsemblBacteriai | AAG06571; AAG06571; PA3183 |
GeneIDi | 882681 |
KEGGi | pae:PA3183 |
PATRICi | fig|208964.12.peg.3327 |
Organism-specific databases
PseudoCAPi | PA3183 |
Phylogenomic databases
HOGENOMi | CLU_013524_5_0_6 |
InParanoidi | O68282 |
OMAi | VEICVYE |
PhylomeDBi | O68282 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00408 |
BioCyci | PAER208964:G1FZ6-3243-MONOMER |
SABIO-RKi | O68282 |
Family and domain databases
HAMAPi | MF_00966, G6PD, 1 hit |
InterProi | View protein in InterPro IPR001282, G6P_DH IPR019796, G6P_DH_AS IPR022675, G6P_DH_C IPR022674, G6P_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR23429, PTHR23429, 1 hit |
Pfami | View protein in Pfam PF02781, G6PD_C, 1 hit PF00479, G6PD_N, 1 hit |
PIRSFi | PIRSF000110, G6PD, 1 hit |
PRINTSi | PR00079, G6PDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00871, zwf, 1 hit |
PROSITEi | View protein in PROSITE PS00069, G6P_DEHYDROGENASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G6PD_PSEAE | |
Accessioni | O68282Primary (citable) accession number: O68282 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families