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Entry version 128 (08 May 2019)
Sequence version 1 (01 Aug 1998)
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Protein
Submitted name:

Na(+):neurotransmitter symporter (Snf family)

Gene

snf

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AAEO224324:G1G15-1482-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.22.4.2 the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Na(+):neurotransmitter symporter (Snf family)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:snfImported
Ordered Locus Names:aq_2077Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAquifex aeolicus (strain VF5)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224324 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000798 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 29HelicalSequence analysisAdd BLAST18
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei92 – 111HelicalSequence analysisAdd BLAST20
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei243 – 268HelicalSequence analysisAdd BLAST26
Transmembranei289 – 314HelicalSequence analysisAdd BLAST26
Transmembranei342 – 367HelicalSequence analysisAdd BLAST26
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei405 – 427HelicalSequence analysisAdd BLAST23
Transmembranei447 – 469HelicalSequence analysisAdd BLAST23
Transmembranei481 – 504HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB08472 (R)-Fluoxetine
DB08544 (S)-Fluoxetine

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224324.aq_2077

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A65X-ray1.65A1-513[»]
2Q6HX-ray1.85A1-513[»]
2Q72X-ray1.70A1-513[»]
2QB4X-ray1.90A1-513[»]
2QEIX-ray1.85A1-513[»]
2QJUX-ray2.90A5-513[»]
3F3AX-ray2.00A1-513[»]
3F3CX-ray2.10A1-513[»]
3F3DX-ray2.30A1-513[»]
3F3EX-ray1.80A1-513[»]
3F48X-ray1.90A1-513[»]
3F4IX-ray1.95A1-513[»]
3F4JX-ray2.15A1-513[»]
3GJCX-ray2.80A/B1-513[»]
3GJDX-ray2.00A1-513[»]
3GWUX-ray2.14A1-513[»]
3GWVX-ray2.35A1-513[»]
3GWWX-ray2.46A1-513[»]
3MPNX-ray2.25A5-511[»]
3MPQX-ray2.25A4-510[»]
3QS4X-ray2.63A1-513[»]
3QS5X-ray2.60A1-513[»]
3QS6X-ray2.80A1-513[»]
3TT1X-ray3.10A/B1-513[»]
3TT3X-ray3.22A1-513[»]
3TU0X-ray2.99A1-513[»]
3USGX-ray2.50A1-513[»]
3USIX-ray3.11A/B1-513[»]
3USJX-ray3.50A/B1-513[»]
3USKX-ray4.50A/B/C/D1-513[»]
3USLX-ray2.71A1-513[»]
3USMX-ray3.01A1-513[»]
3USOX-ray4.50A/B1-513[»]
3USPX-ray2.10A1-513[»]
4FXZX-ray2.60A1-513[»]
4FY0X-ray3.00A1-513[»]
4HMKX-ray3.00A/B1-513[»]
4HODX-ray3.30A1-513[»]
4MM4X-ray2.89A/B1-513[»]
4MM5X-ray3.20A1-513[»]
4MM6X-ray3.10A1-513[»]
4MM7X-ray2.85A1-513[»]
4MM8X-ray3.31A1-513[»]
4MM9X-ray2.90A1-513[»]
4MMAX-ray3.30A1-513[»]
4MMBX-ray2.25A1-513[»]
4MMCX-ray2.30A1-513[»]
4MMDX-ray2.30A/B1-513[»]
4MMEX-ray2.50A/B1-513[»]
4MMFX-ray2.70A/B1-513[»]
5JAEX-ray2.50A/B1-513[»]
5JAFX-ray3.02A1-513[»]
5JAGX-ray2.58A1-513[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O67854

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O67854

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C8J Bacteria
COG0733 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232224

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O67854

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMPAATF

Database of Orthologous Groups

More...
OrthoDBi
376209at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616 PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00209 SNF, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00176 NANEUSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070 SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O67854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKREHWAT RLGLILAMAG NAVGLGNFLR FPVQAAENGG GAFMIPYIIA
60 70 80 90 100
FLLVGIPLMW IEWAMGRYGG AQGHGTTPAI FYLLWRNRFA KILGVFGLWI
110 120 130 140 150
PLVVAIYYVY IESWTLGFAI KFLVGLVPEP PPNATDPDSI LRPFKEFLYS
160 170 180 190 200
YIGVPKGDEP ILKPSLFAYI VFLITMFINV SILIRGISKG IERFAKIAMP
210 220 230 240 250
TLFILAVFLV IRVFLLETPN GTAADGLNFL WTPDFEKLKD PGVWIAAVGQ
260 270 280 290 300
IFFTLSLGFG AIITYASYVR KDQDIVLSGL TAATLNEKAE VILGGSISIP
310 320 330 340 350
AAVAFFGVAN AVAIAKAGAF NLGFITLPAI FSQTAGGTFL GFLWFFLLFF
360 370 380 390 400
AGLTSSIAIM QPMIAFLEDE LKLSRKHAVL WTAAIVFFSA HLVMFLNKSL
410 420 430 440 450
DEMDFWAGTI GVVFFGLTEL IIFFWIFGAD KAWEEINRGG IIKVPRIYYY
460 470 480 490 500
VMRYITPAFL AVLLVVWARE YIPKIMEETH WTVWITRFYI IGLFLFLTFL
510
VFLAERRRNH ESA
Length:513
Mass (Da):57,408
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i409A7B590C58D8BA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07817.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B70478

NCBI Reference Sequences

More...
RefSeqi
NP_214423.1, NC_000918.1
WP_010881359.1, NC_000918.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC07817; AAC07817; aq_2077

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1193843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aae:aq_2077

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07817.1
PIRiB70478
RefSeqiNP_214423.1, NC_000918.1
WP_010881359.1, NC_000918.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A65X-ray1.65A1-513[»]
2Q6HX-ray1.85A1-513[»]
2Q72X-ray1.70A1-513[»]
2QB4X-ray1.90A1-513[»]
2QEIX-ray1.85A1-513[»]
2QJUX-ray2.90A5-513[»]
3F3AX-ray2.00A1-513[»]
3F3CX-ray2.10A1-513[»]
3F3DX-ray2.30A1-513[»]
3F3EX-ray1.80A1-513[»]
3F48X-ray1.90A1-513[»]
3F4IX-ray1.95A1-513[»]
3F4JX-ray2.15A1-513[»]
3GJCX-ray2.80A/B1-513[»]
3GJDX-ray2.00A1-513[»]
3GWUX-ray2.14A1-513[»]
3GWVX-ray2.35A1-513[»]
3GWWX-ray2.46A1-513[»]
3MPNX-ray2.25A5-511[»]
3MPQX-ray2.25A4-510[»]
3QS4X-ray2.63A1-513[»]
3QS5X-ray2.60A1-513[»]
3QS6X-ray2.80A1-513[»]
3TT1X-ray3.10A/B1-513[»]
3TT3X-ray3.22A1-513[»]
3TU0X-ray2.99A1-513[»]
3USGX-ray2.50A1-513[»]
3USIX-ray3.11A/B1-513[»]
3USJX-ray3.50A/B1-513[»]
3USKX-ray4.50A/B/C/D1-513[»]
3USLX-ray2.71A1-513[»]
3USMX-ray3.01A1-513[»]
3USOX-ray4.50A/B1-513[»]
3USPX-ray2.10A1-513[»]
4FXZX-ray2.60A1-513[»]
4FY0X-ray3.00A1-513[»]
4HMKX-ray3.00A/B1-513[»]
4HODX-ray3.30A1-513[»]
4MM4X-ray2.89A/B1-513[»]
4MM5X-ray3.20A1-513[»]
4MM6X-ray3.10A1-513[»]
4MM7X-ray2.85A1-513[»]
4MM8X-ray3.31A1-513[»]
4MM9X-ray2.90A1-513[»]
4MMAX-ray3.30A1-513[»]
4MMBX-ray2.25A1-513[»]
4MMCX-ray2.30A1-513[»]
4MMDX-ray2.30A/B1-513[»]
4MMEX-ray2.50A/B1-513[»]
4MMFX-ray2.70A/B1-513[»]
5JAEX-ray2.50A/B1-513[»]
5JAFX-ray3.02A1-513[»]
5JAGX-ray2.58A1-513[»]
SMRiO67854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_2077

Chemistry databases

DrugBankiDB08472 (R)-Fluoxetine
DB08544 (S)-Fluoxetine

Protein family/group databases

TCDBi2.A.22.4.2 the neurotransmitter:sodium symporter (nss) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07817; AAC07817; aq_2077
GeneIDi1193843
KEGGiaae:aq_2077

Phylogenomic databases

eggNOGiENOG4105C8J Bacteria
COG0733 LUCA
HOGENOMiHOG000232224
InParanoidiO67854
OMAiNMPAATF
OrthoDBi376209at2

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1482-MONOMER

Miscellaneous databases

EvolutionaryTraceiO67854

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 2 hits
PRINTSiPR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO67854_AQUAE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O67854
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 8, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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