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Protein
Submitted name:

Na(+):neurotransmitter symporter (Snf family)

Gene

snf

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1482-MONOMER

Protein family/group databases

TCDBi2.A.22.4.2 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyi

Protein namesi
Submitted name:
Na(+):neurotransmitter symporter (Snf family)Imported
Gene namesi
Name:snfImported
Ordered Locus Names:aq_2077Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 29HelicalSequence analysisAdd BLAST18
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei92 – 111HelicalSequence analysisAdd BLAST20
Transmembranei166 – 185HelicalSequence analysisAdd BLAST20
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei243 – 268HelicalSequence analysisAdd BLAST26
Transmembranei289 – 314HelicalSequence analysisAdd BLAST26
Transmembranei342 – 367HelicalSequence analysisAdd BLAST26
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei405 – 427HelicalSequence analysisAdd BLAST23
Transmembranei447 – 469HelicalSequence analysisAdd BLAST23
Transmembranei481 – 504HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: GO_Central

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB08472 (R)-Fluoxetine
DB08544 (S)-Fluoxetine

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_2077

Structurei

3D structure databases

ProteinModelPortaliO67854
SMRiO67854
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67854

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105C8J Bacteria
COG0733 LUCA
HOGENOMiHOG000232224
InParanoidiO67854
OMAiPFMIMEF
OrthoDBiPOG091H01HU

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 2 hits
PRINTSiPR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

O67854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKREHWAT RLGLILAMAG NAVGLGNFLR FPVQAAENGG GAFMIPYIIA
60 70 80 90 100
FLLVGIPLMW IEWAMGRYGG AQGHGTTPAI FYLLWRNRFA KILGVFGLWI
110 120 130 140 150
PLVVAIYYVY IESWTLGFAI KFLVGLVPEP PPNATDPDSI LRPFKEFLYS
160 170 180 190 200
YIGVPKGDEP ILKPSLFAYI VFLITMFINV SILIRGISKG IERFAKIAMP
210 220 230 240 250
TLFILAVFLV IRVFLLETPN GTAADGLNFL WTPDFEKLKD PGVWIAAVGQ
260 270 280 290 300
IFFTLSLGFG AIITYASYVR KDQDIVLSGL TAATLNEKAE VILGGSISIP
310 320 330 340 350
AAVAFFGVAN AVAIAKAGAF NLGFITLPAI FSQTAGGTFL GFLWFFLLFF
360 370 380 390 400
AGLTSSIAIM QPMIAFLEDE LKLSRKHAVL WTAAIVFFSA HLVMFLNKSL
410 420 430 440 450
DEMDFWAGTI GVVFFGLTEL IIFFWIFGAD KAWEEINRGG IIKVPRIYYY
460 470 480 490 500
VMRYITPAFL AVLLVVWARE YIPKIMEETH WTVWITRFYI IGLFLFLTFL
510
VFLAERRRNH ESA
Length:513
Mass (Da):57,408
Last modified:August 1, 1998 - v1
Checksum:i409A7B590C58D8BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07817.1
PIRiB70478
RefSeqiNP_214423.1, NC_000918.1
WP_010881359.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07817; AAC07817; aq_2077
GeneIDi1193843
KEGGiaae:aq_2077

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07817.1
PIRiB70478
RefSeqiNP_214423.1, NC_000918.1
WP_010881359.1, NC_000918.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A65X-ray1.65A1-513[»]
2Q6HX-ray1.85A1-513[»]
2Q72X-ray1.70A1-513[»]
2QB4X-ray1.90A1-513[»]
2QEIX-ray1.85A1-513[»]
2QJUX-ray2.90A5-513[»]
3F3AX-ray2.00A1-513[»]
3F3CX-ray2.10A1-513[»]
3F3DX-ray2.30A1-513[»]
3F3EX-ray1.80A1-513[»]
3F48X-ray1.90A1-513[»]
3F4IX-ray1.95A1-513[»]
3F4JX-ray2.15A1-513[»]
3GJCX-ray2.80A/B1-513[»]
3GJDX-ray2.00A1-513[»]
3GWUX-ray2.14A1-513[»]
3GWVX-ray2.35A1-513[»]
3GWWX-ray2.46A1-513[»]
3MPNX-ray2.25A5-511[»]
3MPQX-ray2.25A4-510[»]
3QS4X-ray2.63A1-513[»]
3QS5X-ray2.60A1-513[»]
3QS6X-ray2.80A1-513[»]
3TT1X-ray3.10A/B1-513[»]
3TT3X-ray3.22A1-513[»]
3TU0X-ray2.99A1-513[»]
3USGX-ray2.50A1-513[»]
3USIX-ray3.11A/B1-513[»]
3USJX-ray3.50A/B1-513[»]
3USKX-ray4.50A/B/C/D1-513[»]
3USLX-ray2.71A1-513[»]
3USMX-ray3.01A1-513[»]
3USOX-ray4.50A/B1-513[»]
3USPX-ray2.10A1-513[»]
4FXZX-ray2.60A1-513[»]
4FY0X-ray3.00A1-513[»]
4HMKX-ray3.00A/B1-513[»]
4HODX-ray3.30A1-513[»]
4MM4X-ray2.89A/B1-513[»]
4MM5X-ray3.20A1-513[»]
4MM6X-ray3.10A1-513[»]
4MM7X-ray2.85A1-513[»]
4MM8X-ray3.31A1-513[»]
4MM9X-ray2.90A1-513[»]
4MMAX-ray3.30A1-513[»]
4MMBX-ray2.25A1-513[»]
4MMCX-ray2.30A1-513[»]
4MMDX-ray2.30A/B1-513[»]
4MMEX-ray2.50A/B1-513[»]
4MMFX-ray2.70A/B1-513[»]
5JAEX-ray2.50A/B1-513[»]
5JAFX-ray3.02A1-513[»]
5JAGX-ray2.58A1-513[»]
ProteinModelPortaliO67854
SMRiO67854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_2077

Chemistry databases

DrugBankiDB08472 (R)-Fluoxetine
DB08544 (S)-Fluoxetine

Protein family/group databases

TCDBi2.A.22.4.2 the neurotransmitter:sodium symporter (nss) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07817; AAC07817; aq_2077
GeneIDi1193843
KEGGiaae:aq_2077

Phylogenomic databases

eggNOGiENOG4105C8J Bacteria
COG0733 LUCA
HOGENOMiHOG000232224
InParanoidiO67854
OMAiPFMIMEF
OrthoDBiPOG091H01HU

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1482-MONOMER

Miscellaneous databases

EvolutionaryTraceiO67854

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 2 hits
PRINTSiPR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO67854_AQUAE
AccessioniPrimary (citable) accession number: O67854
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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