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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.By similarity

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • dephospho-CoA kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1420-MONOMER
UniPathwayi
UPA00241;UER00356

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase (EC:2.7.1.24)
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:coaE
Ordered Locus Names:aq_1985
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001729001 – 196Dephospho-CoA kinaseAdd BLAST196

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1985

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO67792
SMRiO67792
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67792

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 196DPCKAdd BLAST194

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZQD Bacteria
COG0237 LUCA
HOGENOMiHOG000020768
InParanoidiO67792
KOiK00859
OMAiVTEIWVV
OrthoDBiPOG091H02KX

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequencei

Sequence statusi: Complete.

O67792-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRIGLTGNI GCGKSTVAQM FRELGAYVLD ADKLIHSFYR KGHPVYEEVV
60 70 80 90 100
KTFGKGILDE EGNIDRKKLA DIVFKDEEKL RKLEEITHRA LYKEIEKITK
110 120 130 140 150
NLSEDTLFIL EASLLVEKGT YKNYDKLIVV YAPYEVCKER AIKRGMSEED
160 170 180 190
FERRWKKQMP IEEKVKYADY VIDNSGSIEE TYKQVKKVYE ELTRDP
Length:196
Mass (Da):22,930
Last modified:August 1, 1998 - v1
Checksum:iDD691CBCD7B1C0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07761.1
PIRiD70470
RefSeqiNP_214361.1, NC_000918.1
WP_010881297.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07761; AAC07761; aq_1985
GeneIDi1193689
KEGGiaae:aq_1985
PATRICifig|224324.8.peg.1534

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07761.1
PIRiD70470
RefSeqiNP_214361.1, NC_000918.1
WP_010881297.1, NC_000918.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IF2X-ray3.00A/B/C1-196[»]
ProteinModelPortaliO67792
SMRiO67792
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1985

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07761; AAC07761; aq_1985
GeneIDi1193689
KEGGiaae:aq_1985
PATRICifig|224324.8.peg.1534

Phylogenomic databases

eggNOGiENOG4108ZQD Bacteria
COG0237 LUCA
HOGENOMiHOG000020768
InParanoidiO67792
KOiK00859
OMAiVTEIWVV
OrthoDBiPOG091H02KX

Enzyme and pathway databases

UniPathwayi
UPA00241;UER00356

BioCyciAAEO224324:G1G15-1420-MONOMER

Miscellaneous databases

EvolutionaryTraceiO67792

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_AQUAE
AccessioniPrimary (citable) accession number: O67792
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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