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Protein

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene

thiD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphomethyl)pyrimidine.By similarity
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine.By similarity

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (thiD)
  3. Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (thiD)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processThiamine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1400-MONOMER
UniPathwayi
UPA00060;UER00137

UPA00060;UER00138

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49By similarity, EC:2.7.4.7By similarity)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
Name:thiD
Ordered Locus Names:aq_1960
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001920161 – 255Hydroxymethylpyrimidine/phosphomethylpyrimidine kinaseAdd BLAST255

Proteomic databases

PRIDEiO67772

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1960

Structurei

3D structure databases

ProteinModelPortaliO67772
SMRiO67772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.Curated

Phylogenomic databases

eggNOGiENOG4105DWF Bacteria
COG0351 LUCA
HOGENOMiHOG000225273
InParanoidiO67772
KOiK00941
OMAiVKIGMLH
OrthoDBiPOG091H01V0

Family and domain databases

CDDicd01169 HMPP_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
InterProiView protein in InterPro
IPR004399 HMP/HMP-P_kinase
IPR013749 PM/HMP-P_kinase-1
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF08543 Phos_pyr_kin, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00097 HMP-P_kinase, 1 hit

Sequencei

Sequence statusi: Complete.

O67772-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIALSIAGFD NSGGAGTLAD IRTFKHFGIY GVAVITALAV QNTQKVYEVF
60 70 80 90 100
PIPPDVVKEE LKAIFEDFPI KGVKIGMLAN KEIAEVVYET LKSKKTNFIV
110 120 130 140 150
LDPVFRSKSG RELLSEEGVE FLKSEFIKIV DLITPNVPEA EILCGEEIKS
160 170 180 190 200
LEDVKNCAQK IYSLGAKSVL IKGGHLKGNY AIDILYDGKS FYEFKAPKIA
210 220 230 240 250
GKTPRGTGCV YSSAILANYL RHKDLIKAIK TAKDFITEAI KNSKKLGKGY

EIMDF
Length:255
Mass (Da):28,066
Last modified:August 1, 1998 - v1
Checksum:i95A4CA5F662F708F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07733.1
PIRiH70467
RefSeqiNP_214341.1, NC_000918.1
WP_010881277.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07733; AAC07733; aq_1960
GeneIDi1193669
KEGGiaae:aq_1960

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07733.1
PIRiH70467
RefSeqiNP_214341.1, NC_000918.1
WP_010881277.1, NC_000918.1

3D structure databases

ProteinModelPortaliO67772
SMRiO67772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1960

Proteomic databases

PRIDEiO67772

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07733; AAC07733; aq_1960
GeneIDi1193669
KEGGiaae:aq_1960

Phylogenomic databases

eggNOGiENOG4105DWF Bacteria
COG0351 LUCA
HOGENOMiHOG000225273
InParanoidiO67772
KOiK00941
OMAiVKIGMLH
OrthoDBiPOG091H01V0

Enzyme and pathway databases

UniPathwayi
UPA00060;UER00137

UPA00060;UER00138

BioCyciAAEO224324:G1G15-1400-MONOMER

Family and domain databases

CDDicd01169 HMPP_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
InterProiView protein in InterPro
IPR004399 HMP/HMP-P_kinase
IPR013749 PM/HMP-P_kinase-1
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF08543 Phos_pyr_kin, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00097 HMP-P_kinase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHID_AQUAE
AccessioniPrimary (citable) accession number: O67772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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