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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65NucleophileUniRule annotation1

GO - Molecular functioni

  • pseudouridine synthase activity Source: GO_Central
  • RNA binding Source: InterPro
  • tRNA pseudouridine synthase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1227-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:aq_1723
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524911 – 385tRNA pseudouridine synthase DAdd BLAST385

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1723

Structurei

3D structure databases

ProteinModelPortaliO67616
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 345TRUDUniRule annotationAdd BLAST203

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000254431
InParanoidiO67616
KOiK06176
OMAiLRYERAM
OrthoDBiPOG091H03KK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

O67616-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIRIKEKPE EFYVKEIKKL DLKEKGQYAY FLLKKKDMTT LDAVRHISHR
60 70 80 90 100
FGIPLKNIGF AGLKDKKAVT EQYISVKDLN EEKIRKMDGY RTENLELKFL
110 120 130 140 150
GFSDKGLELG EIEGNYFEVV VRGVTKYHRR VFPRMKELVE NYGCENYFGE
160 170 180 190 200
QRFGSVKHAE EFIVKYLLRH EYEEAMKEYL TSLGDKRLKR LLRKAWRDWD
210 220 230 240 250
RFLSLMPKGA KPELEVVKAL RRGESFKNAF MVLPKNIRLM FVFAYQSYLW
260 270 280 290 300
NRYLYTFVVR YLKYCKTPFL KWELAFFNDM SEVIWEEIKD LEIPYLGVEY
310 320 330 340 350
KPRNKKAEIV MKEVLQDEGI TPKMLMAERI GIKLFSDGVR KAFFKPQGLK
360 370 380
VIEERKNSLK LSFTLPPGSY ATILLRKLFC SDVKS
Length:385
Mass (Da):45,775
Last modified:August 1, 1998 - v1
Checksum:i84DCA37687111833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07586.1
PIRiF70448
RefSeqiNP_214182.1, NC_000918.1
WP_010881119.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07586; AAC07586; aq_1723
GeneIDi1193331
KEGGiaae:aq_1723
PATRICifig|224324.8.peg.1324

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07586.1
PIRiF70448
RefSeqiNP_214182.1, NC_000918.1
WP_010881119.1, NC_000918.1

3D structure databases

ProteinModelPortaliO67616
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_1723

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07586; AAC07586; aq_1723
GeneIDi1193331
KEGGiaae:aq_1723
PATRICifig|224324.8.peg.1324

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000254431
InParanoidiO67616
KOiK06176
OMAiLRYERAM
OrthoDBiPOG091H03KK

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-1227-MONOMER

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_AQUAE
AccessioniPrimary (citable) accession number: O67616
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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