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Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7SubstrateBy similarity1
Metal bindingi32Divalent metal cationBy similarity1
Active sitei34Proton acceptorBy similarity1
Metal bindingi34Divalent metal cationBy similarity1
Metal bindingi65Divalent metal cationBy similarity1
Binding sitei65SubstrateBy similarity1
Active sitei174Proton donorBy similarity1
Metal bindingi174Divalent metal cationBy similarity1
Binding sitei176Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-688-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:aq_968
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001715601 – 222Ribulose-phosphate 3-epimeraseAdd BLAST222

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_968

Structurei

3D structure databases

ProteinModelPortaliO67098
SMRiO67098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni141 – 144Substrate bindingBy similarity4
Regioni196 – 197Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DJV Bacteria
COG0036 LUCA
HOGENOMiHOG000259347
InParanoidiO67098
KOiK01783
OMAiCHLMIED
OrthoDBiPOG091H01TC

Family and domain databases

CDDicd00429 RPE, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR11749 PTHR11749, 1 hit
PfamiView protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit
PIRSFiPIRSF001461 RPE, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01163 rpe, 1 hit
PROSITEiView protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit

Sequencei

Sequence statusi: Complete.

O67098-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLAPSILA GDWWCIGEQI QATIRGGADI LHYDVMDGHF VPNITAGYEI
60 70 80 90 100
LSHIRKRASL PIDAHLMIEN PDKYIPKFVE AGANWISVHI ENNYHIHRTL
110 120 130 140 150
QLIKELGAKA GVVVNPGTSL SAIEEALYYA DYVLLMSVNP GFSGQKFIER
160 170 180 190 200
SIERLRILKE MRDRINPSCL IEIDGGIKEN NIAEVVRAGA DVVVVGSGIF
210 220
GAKDIEAQTR KLKSLMLSAV SV
Length:222
Mass (Da):24,489
Last modified:August 1, 1998 - v1
Checksum:iB4DB8BF805FDDC68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07062.1
PIRiG70383
RefSeqiNP_213661.1, NC_000918.1
WP_010880599.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07062; AAC07062; aq_968
GeneIDi1193640
KEGGiaae:aq_968
PATRICifig|224324.8.peg.761

Similar proteinsi

Entry informationi

Entry nameiRPE_AQUAE
AccessioniPrimary (citable) accession number: O67098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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