UniProtKB - O67085 (CMPDT_AQUAE)
Protein
Bifunctional chorismate mutase/prephenate dehydratase
Gene
pheA
Organism
Aquifex aeolicus (strain VF5)
Status
Functioni
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.By similarity
Catalytic activityi
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.By similarityProteins known to be involved in this subpathway in this organism are:
- Bifunctional chorismate mutase/prephenate dehydratase (pheA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
Pathwayi: prephenate biosynthesis
This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.By similarityProteins known to be involved in this subpathway in this organism are:
- Bifunctional chorismate mutase/prephenate dehydratase (pheA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 8 | SubstrateBy similarity | 1 | |
Binding sitei | 25 | SubstrateBy similarity | 1 | |
Binding sitei | 36 | SubstrateBy similarity | 1 | |
Binding sitei | 49 | SubstrateBy similarity | 1 | |
Sitei | 260 | Essential for prephenate dehydratase activitySequence analysis | 1 |
GO - Molecular functioni
- chorismate mutase activity Source: UniProtKB-EC
- prephenate dehydratase activity Source: GO_Central
GO - Biological processi
- chorismate metabolic process Source: InterPro
- L-phenylalanine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Isomerase, Lyase, Multifunctional enzyme |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis |
Enzyme and pathway databases
BioCyci | AAEO224324:G1G15-675-MONOMER |
UniPathwayi | UPA00120;UER00203 UPA00121;UER00345 |
Names & Taxonomyi
Protein namesi | Recommended name: Bifunctional chorismate mutase/prephenate dehydrataseBy similarityAlternative name(s): Chorismate mutase-prephenate dehydrataseBy similarity P-proteinBy similarity Including the following 2 domains: |
Gene namesi | Name:pheA Ordered Locus Names:aq_951 |
Organismi | Aquifex aeolicus (strain VF5) |
Taxonomic identifieri | 224324 [NCBI] |
Taxonomic lineagei | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119181 | 1 – 362 | Bifunctional chorismate mutase/prephenate dehydrataseAdd BLAST | 362 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 92 | Chorismate mutasePROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 93 – 267 | Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST | 175 | |
Domaini | 279 – 356 | ACTPROSITE-ProRule annotationAdd BLAST | 78 |
Phylogenomic databases
eggNOGi | COG0077, Bacteria COG1605, Bacteria |
HOGENOMi | CLU_035008_0_1_0 |
InParanoidi | O67085 |
OMAi | REVMSAC |
OrthoDBi | 1280729at2 |
Family and domain databases
Gene3Di | 1.20.59.10, 1 hit |
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR036263, Chorismate_II_sf IPR036979, CM_dom_sf IPR002701, CM_II_prokaryot IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF01817, CM_2, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
SMARTi | View protein in SMART SM00830, CM_2, 1 hit |
SUPFAMi | SSF48600, SSF48600, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS51168, CHORISMATE_MUT_2, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O67085-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEELKELRKE IDRIDEEILR LLNERAKLAK RIGEIKSKAN LPIHVPERER
60 70 80 90 100
EIFEKILRLN KEVYGGVFPQ EALVHIYREI ISACLSLEKK IKVAYLGPKA
110 120 130 140 150
TFTHQAALEF FGFSAHYTPC STIRDVFVEV ETKRADYGVV PVENTIEGVV
160 170 180 190 200
NYTLDMFLES DVKIAGEIVI PITLHLLSAS DSIENVEKVY SHKMALAQCR
210 220 230 240 250
SWLEKNLPSV QVIEVESTAK ACEIALEDER AGAVASEVAA YTYHLNILAR
260 270 280 290 300
NIQDSGDNFT RFLVIAKRDL KPTGSDKTSI LFGVKDEPGA LYKALEVFYK
310 320 330 340 350
HGINLTKIES RPSKKKAWDY VFFVDLEGHK EEERVEKALK ELKEKTQFLK
360
VLGSYPKALL QE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC07041.1 |
PIRi | B70382 |
RefSeqi | NP_213648.1, NC_000918.1 WP_010880586.1, NC_000918.1 |
Genome annotation databases
EnsemblBacteriai | AAC07041; AAC07041; aq_951 |
KEGGi | aae:aq_951 |
PATRICi | fig|224324.8.peg.746 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC07041.1 |
PIRi | B70382 |
RefSeqi | NP_213648.1, NC_000918.1 WP_010880586.1, NC_000918.1 |
3D structure databases
SMRi | O67085 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224324.aq_951 |
Genome annotation databases
EnsemblBacteriai | AAC07041; AAC07041; aq_951 |
KEGGi | aae:aq_951 |
PATRICi | fig|224324.8.peg.746 |
Phylogenomic databases
eggNOGi | COG0077, Bacteria COG1605, Bacteria |
HOGENOMi | CLU_035008_0_1_0 |
InParanoidi | O67085 |
OMAi | REVMSAC |
OrthoDBi | 1280729at2 |
Enzyme and pathway databases
UniPathwayi | UPA00120;UER00203 UPA00121;UER00345 |
BioCyci | AAEO224324:G1G15-675-MONOMER |
Family and domain databases
Gene3Di | 1.20.59.10, 1 hit |
InterProi | View protein in InterPro IPR002912, ACT_dom IPR008242, Chor_mutase/pphenate_deHydtase IPR036263, Chorismate_II_sf IPR036979, CM_dom_sf IPR002701, CM_II_prokaryot IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF01842, ACT, 1 hit PF01817, CM_2, 1 hit PF00800, PDT, 1 hit |
PIRSFi | PIRSF001500, Chor_mut_pdt_Ppr, 1 hit |
SMARTi | View protein in SMART SM00830, CM_2, 1 hit |
SUPFAMi | SSF48600, SSF48600, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS51168, CHORISMATE_MUT_2, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CMPDT_AQUAE | |
Accessioni | O67085Primary (citable) accession number: O67085 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways