UniProtKB - O66939 (O66939_AQUAE)
Protein
Submitted name:
D-lactate dehydrogenase
Gene
ldhA
Organism
Aquifex aeolicus (strain VF5)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 96 | LactateCombined sources | 1 | |
Binding sitei | 171 | NADCombined sources | 1 | |
Binding sitei | 203 | NADCombined sources | 1 | |
Binding sitei | 231 | LactateCombined sources | 1 | |
Binding sitei | 255 | NADCombined sources | 1 | |
Binding sitei | 294 | LactateCombined sources | 1 | |
Binding sitei | 297 | NAD; via amide nitrogenCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 151 – 152 | NADCombined sources | 2 | |
Nucleotide bindingi | 229 – 231 | NADCombined sources | 3 |
GO - Molecular functioni
- NAD binding Source: InterPro
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotation |
Ligand | NADCombined sources, Nucleotide-bindingCombined sources |
Enzyme and pathway databases
BioCyci | AAEO224324:G1G15-520-MONOMER |
BRENDAi | 1.1.1.28 396 |
Names & Taxonomyi
Protein namesi | Submitted name: D-lactate dehydrogenaseImported |
Gene namesi | Name:ldhAImported Ordered Locus Names:aq_727Imported |
Organismi | Aquifex aeolicus (strain VF5)Imported |
Taxonomic identifieri | 224324 [NCBI] |
Taxonomic lineagei | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex › |
Proteomesi |
|
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 169 ↔ 183 | Combined sources |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KB6 | X-ray | 2.12 | A/B/C/D | 1-334 | [»] | |
ProteinModelPortali | O66939 | |||||
SMRi | O66939 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O66939 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 321 | 2-Hacid_dhInterPro annotationAdd BLAST | 319 | |
Domaini | 106 – 296 | 2-Hacid_dh_CInterPro annotationAdd BLAST | 191 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 73 – 74 | Lactate bindingCombined sources | 2 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C5I Bacteria COG1052 LUCA |
HOGENOMi | HOG000136695 |
InParanoidi | O66939 |
KOi | K03778 |
OMAi | THKAYNR |
OrthoDBi | 1638924at2 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O66939-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVLFTSVPQ EDVPFYQEAL KDLSLKIYTT DVSKVPENEL KKAELISVFV
60 70 80 90 100
YDKLTEELLS KMPRLKLIHT RSVGFDHIDL DYCKKKGILV THIPAYSPES
110 120 130 140 150
VAEHTFAMIL TLVKRLKRIE DRVKKLNFSQ DSEILARELN RLTLGVIGTG
160 170 180 190 200
RIGSRVAMYG LAFGMKVLCY DVVKREDLKE KGCVYTSLDE LLKESDVISL
210 220 230 240 250
HVPYTKETHH MINEERISLM KDGVYLINTA RGKVVDTDAL YRAYQRGKFS
260 270 280 290 300
GLGLDVFEDE EILILKKYTE GKATDKNLKI LELACKDNVI ITPHIAYYTD
310 320 330
KSLERIREET VKVVKAFVKG DLEQIKGNFV VGPS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC06898.1 |
PIRi | G70363 |
RefSeqi | NP_213499.1, NC_000918.1 WP_010880437.1, NC_000918.1 |
Genome annotation databases
EnsemblBacteriai | AAC06898; AAC06898; aq_727 |
GeneIDi | 1193388 |
KEGGi | aae:aq_727 |
PATRICi | fig|224324.8.peg.582 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC06898.1 |
PIRi | G70363 |
RefSeqi | NP_213499.1, NC_000918.1 WP_010880437.1, NC_000918.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KB6 | X-ray | 2.12 | A/B/C/D | 1-334 | [»] | |
ProteinModelPortali | O66939 | |||||
SMRi | O66939 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 224324.aq_727 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | AAC06898; AAC06898; aq_727 |
GeneIDi | 1193388 |
KEGGi | aae:aq_727 |
PATRICi | fig|224324.8.peg.582 |
Phylogenomic databases
eggNOGi | ENOG4105C5I Bacteria COG1052 LUCA |
HOGENOMi | HOG000136695 |
InParanoidi | O66939 |
KOi | K03778 |
OMAi | THKAYNR |
OrthoDBi | 1638924at2 |
Enzyme and pathway databases
BioCyci | AAEO224324:G1G15-520-MONOMER |
BRENDAi | 1.1.1.28 396 |
Miscellaneous databases
EvolutionaryTracei | O66939 |
Family and domain databases
InterProi | View protein in InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O66939_AQUAE | |
Accessioni | O66939Primary (citable) accession number: O66939 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 1, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | January 16, 2019 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |