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UniProtKB - O66841 (NUOF_AQUAE)

Entry version 125 (07 Apr 2021)
Sequence version 1 (01 Aug 1998)
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Protein

NADH-quinone oxidoreductase subunit F

Gene

nuoF

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi347Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi350Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi353Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi393Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi65 – 74NADBy similarity10
Nucleotide bindingi176 – 223FMNBy similarityAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Ligand4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		AAEO224324:G1G15-418-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit F (EC:7.1.1.-)
Alternative name(s):
NADH dehydrogenase I subunit F
NDH-1 subunit F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nuoF
Ordered Locus Names:aq_573
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAquifex aeolicus (strain VF5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224324 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000798 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001185701 – 426NADH-quinone oxidoreductase subunit FAdd BLAST426

Keywords - PTMi

Quinone

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		224324.aq_573

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O66841

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1894, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014881_0_1_0

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O66841

Identification of Orthologs from Complete Genome Data

More...OMAi		CREGTDW

Database of Orthologous Groups

More...OrthoDBi		688908at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1440.230, 1 hit
3.40.50.11540, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001949, NADH-UbQ_OxRdtase_51kDa_CS
IPR011538, Nuo51_FMN-bd
IPR037225, Nuo51_FMN-bd_sf
IPR019575, Nuop51_4Fe4S-bd
IPR037207, Nuop51_4Fe4S-bd_sf
IPR019554, Soluble_ligand-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01512, Complex1_51K, 1 hit
PF10589, NADH_4Fe-4S, 1 hit
PF10531, SLBB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00928, NADH_4Fe-4S, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF140490, SSF140490, 1 hit
SSF142019, SSF142019, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00644, COMPLEX1_51K_1, 1 hit
PS00645, COMPLEX1_51K_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O66841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSYPAIPRI YAETTLNMLL KRAKKPRVHS IDEYLKDGGY QALEKALNMS 
        60         70         80         90        100
PEEIIDWVDK STLRGRGGAG FPTGKKWKFA VQNPGPRYFI CNADESEPGT 
       110        120        130        140        150
FKDRIIIERD PHLLIEGIII SSYAIGANEA YIYIRGEYPA GYYILRDAIE 
       160        170        180        190        200
EAKKKGFLGK NILGSGFDLE IYVARGAGAY ICGEETALIE SLEGKRGHPR 
       210        220        230        240        250
LKPPYPVQKG LWGKPTVVNN VETIANVPFI ISMGWEEYRY IGPSDYAGPK 
       260        270        280        290        300
LFPVSGKVKK PGVYELPMNT TLREVIFKYA GGTLGNKKVK AVFSGALDCF 
       310        320        330        340        350
SSEELDIPMD YSPLGFGGTG TVIVLTEEDD IVEAALKIAE FYEHETCGQC 
       360        370        380        390        400
TPCRVGCYEQ ANLLEKIYKG EATEQDWEGF DFVNRNIQPT SICGLGAVAG 
       410        420 
RLIRQTLEKF PEEWEKYRKK SASLPL
Length:426
Mass (Da):47,508
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA876712CBFA2E122
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06800.1

Protein sequence database of the Protein Information Resource

More...PIRi		E70351

NCBI Reference Sequences

More...RefSeqi		NP_213401.1, NC_000918.1
WP_010880339.1, NC_000918.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC06800; AAC06800; aq_573

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		aae:aq_573

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|224324.8.peg.468

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06800.1
PIRiE70351
RefSeqiNP_213401.1, NC_000918.1
WP_010880339.1, NC_000918.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HL2X-ray1.95B/D1-426[»]
6HL3X-ray2.04B/D1-426[»]
6HL4X-ray2.06B/D1-426[»]
6HLAX-ray1.90B/D1-426[»]
6HLIX-ray2.38B/D1-426[»]
6HLJX-ray2.10B/D1-426[»]
6HLMX-ray1.80B/D1-426[»]
6Q9CX-ray1.78B/D2-419[»]
6Q9GX-ray2.10B/D1-426[»]
6Q9JX-ray1.83B/D1-426[»]
6Q9KX-ray1.99B/D2-419[»]
6R7PX-ray3.22B/D1-426[»]
6SAQX-ray2.02B/D1-426[»]
SMRiO66841
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_573

Genome annotation databases

EnsemblBacteriaiAAC06800; AAC06800; aq_573
KEGGiaae:aq_573
PATRICifig|224324.8.peg.468

Phylogenomic databases

eggNOGiCOG1894, Bacteria
HOGENOMiCLU_014881_0_1_0
InParanoidiO66841
OMAiCREGTDW
OrthoDBi688908at2

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-418-MONOMER

Family and domain databases

Gene3Di1.20.1440.230, 1 hit
3.40.50.11540, 1 hit
InterProiView protein in InterPro
IPR001949, NADH-UbQ_OxRdtase_51kDa_CS
IPR011538, Nuo51_FMN-bd
IPR037225, Nuo51_FMN-bd_sf
IPR019575, Nuop51_4Fe4S-bd
IPR037207, Nuop51_4Fe4S-bd_sf
IPR019554, Soluble_ligand-bd
PfamiView protein in Pfam
PF01512, Complex1_51K, 1 hit
PF10589, NADH_4Fe-4S, 1 hit
PF10531, SLBB, 1 hit
SMARTiView protein in SMART
SM00928, NADH_4Fe-4S, 1 hit
SUPFAMiSSF140490, SSF140490, 1 hit
SSF142019, SSF142019, 1 hit
PROSITEiView protein in PROSITE
PS00644, COMPLEX1_51K_1, 1 hit
PS00645, COMPLEX1_51K_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUOF_AQUAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O66841
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 7, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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