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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateUniRule annotation1
Binding sitei39Substrate; via amide nitrogenUniRule annotation1
Binding sitei68Pyridoxal phosphateUniRule annotation1
Binding sitei103SubstrateUniRule annotation1
Binding sitei127Pyridoxal phosphateUniRule annotation1
Binding sitei127SubstrateUniRule annotation1
Binding sitei177Pyridoxal phosphateUniRule annotation1
Binding sitei177SubstrateUniRule annotation1
Binding sitei208Pyridoxal phosphateUniRule annotation1
Binding sitei247Pyridoxal phosphateUniRule annotation1
Binding sitei365SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-205-MONOMER
BRENDAi2.6.1.83 396
UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:aq_273
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422121 – 387LL-diaminopimelate aminotransferaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei239N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_273

Structurei

3D structure databases

ProteinModelPortaliO66630
SMRiO66630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 103Pyridoxal phosphate bindingUniRule annotation2
Regioni236 – 238Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223051
InParanoidiO66630
KOiK10206
OMAiYPHMPTG
OrthoDBiPOG091H09WQ

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019881 DAP-NH2Trfase_DapL_Desulfo
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03540 DapC_direct, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

O66630-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEFSDRLKV LPPYLFAELD RKKQEKIEQG VDVIDLGVGD PDMPTPKPIV
60 70 80 90 100
EAAKKALENP ENHKYPSYVG KYEFRKAVAD WYKRRFDVDL DPNTEVITLI
110 120 130 140 150
GSKEGIAHFP LAFVNPGDIV LCPDPAYPVY RIGAIFAGGT PYTVPLKEEN
160 170 180 190 200
NFLPDLDSIP EDVAKKAKII WINYPNNPTS APPTLEFYKK LVDWAKEYNV
210 220 230 240 250
IIASDNAYSE IYTGQEKPPS ILQVPGAKDV AIEFHSLSKT YNMTGWRIGM
260 270 280 290 300
AVGNKELVAG LGKVKTNVDS GQFGAVQDAG IVALNLPEEE VEKIRDVYRE
310 320 330 340 350
RKKIMTEALE KIGLEIYRSD YTFYLWIKVP EGYTSAEFVG RLIDEAGIVC
360 370 380
TPGNGFGEYG EGYFRISLTV PTERLLEAAE RIKNLKL
Length:387
Mass (Da):43,444
Last modified:August 1, 1998 - v1
Checksum:iEB0DCF52115A0377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06578.1
PIRiB70325
RefSeqiNP_213190.1, NC_000918.1
WP_010880128.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC06578; AAC06578; aq_273
GeneIDi1192864
KEGGiaae:aq_273
PATRICifig|224324.8.peg.227

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06578.1
PIRiB70325
RefSeqiNP_213190.1, NC_000918.1
WP_010880128.1, NC_000918.1

3D structure databases

ProteinModelPortaliO66630
SMRiO66630
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_273

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06578; AAC06578; aq_273
GeneIDi1192864
KEGGiaae:aq_273
PATRICifig|224324.8.peg.227

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223051
InParanoidiO66630
KOiK10206
OMAiYPHMPTG
OrthoDBiPOG091H09WQ

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

BioCyciAAEO224324:G1G15-205-MONOMER
BRENDAi2.6.1.83 396

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019881 DAP-NH2Trfase_DapL_Desulfo
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03540 DapC_direct, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_AQUAE
AccessioniPrimary (citable) accession number: O66630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 1, 1998
Last modified: October 10, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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