Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Nitrite reductase (NAD(P)H) large subunit

Gene

nirB

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Ligand4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AAEO224324:G1G15-156-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nitrite reductase (NAD(P)H) large subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nirBImported
Ordered Locus Names:aq_206Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAquifex aeolicus (strain VF5)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224324 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000798 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224324.aq_206

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O66583

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 280Pyr_redox_2InterPro annotationAdd BLAST280
Domaini414 – 462Fer2_BFDInterPro annotationAdd BLAST49
Domaini523 – 587NIR_SIR_ferrInterPro annotationAdd BLAST65
Domaini597 – 750NIR_SIRInterPro annotationAdd BLAST154
Domaini773 – 830NIR_SIR_ferrInterPro annotationAdd BLAST58
Domaini875 – 983NIR_SIRInterPro annotationAdd BLAST109

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107QZF Bacteria
COG0155 LUCA
COG1251 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115024

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O66583

KEGG Orthology (KO)

More...
KOi
K00362

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITTFCEE

Database of Orthologous Groups

More...
OrthoDBi
POG091H0PCN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.390.30, 1 hit
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007419 BFD-like_2Fe2S-bd_dom
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR005117 NiRdtase/SiRdtase_haem-b_fer
IPR036136 Nit/Sulf_reduc_fer_like_dom_sf
IPR006067 NO2/SO3_Rdtase_4Fe4S_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04324 Fer2_BFD, 1 hit
PF01077 NIR_SIR, 2 hits
PF03460 NIR_SIR_ferr, 2 hits
PF07992 Pyr_redox_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 2 hits
SSF55124 SSF55124, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O66583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVVIVGNGI AGTALVEEIL RLSSGKDIRI QVFGDEKFIG YNRVLITEVL
60 70 80 90 100
AGRKTLSEIY IKRWQWYEEK GVRLEIGKKV ERLFPNKKIL VTKDGEFYRY
110 120 130 140 150
DKAIIATGSK PFIPPSIKGV NKKGVFTYRT AKDVFEILDY ARVSKRAVVI
160 170 180 190 200
GGGLLGIEVT KALRDIGLEV FLVHILDTLM EQQLDKTASE LLRKDLEDMG
210 220 230 240 250
IKVLLKKVTE EILGEKKAEG VRFSDGDELL ADFVIIATGI RPNVEVGVNS
260 270 280 290 300
GLKVNKGIVV NDYLETSASD IYAVGECIEH RGKTYGLVAP IMEQVKVCAH
310 320 330 340 350
NVVHGNEKKY TGSLTYAMLK VAGVNLFSAG EINEKDGDEV VAFLDNGRSL
360 370 380 390 400
YRKAVIRNNK IVGTILYGDV RGNNYLLDLI KSGKDISEER PYFLIKHILP
410 420 430 440 450
KGTTGVEELK DNDIVCNCNA VTKGEIVKCI KEGCKTLEEI QERTKASTSC
460 470 480 490 500
GSCIELVEEI LKHYVKEKPK RVNKIEVIKK ELHPFDLEFK KRLEKYFSEG
510 520 530 540 550
ELENIPEEDR DVRLKWYGIF YRKATPGYFM VRIRVPNGRL SYEQAKVVSH
560 570 580 590 600
ISEKFCRGEV EITSRQQLQI RWIKLKDLPE ILEALNRVGL STLQTGMDNV
610 620 630 640 650
RNVTGDPLTG LAEDSLIDTL RLSQEITNIF LGKKKYADLP RKLNVAVLGS
660 670 680 690 700
QTDCINALFN DVCFYLSEKD GKLGFNLYLG GKIGSGGPKK AIDMDMFVEP
710 720 730 740 750
YEVPEVFKAT LDIYSTFGNR ENRSKNRLYF LLQEWGVERF REELEKRLYK
760 770 780 790 800
AIPSKGKDLV NKTGEREGII NLRNGTYAVC VVVPAGKIKA KDFRQIAELA
810 820 830 840 850
RKYGSRELRL SVYQNIYIPN IPEENLNPLL GEEIFEKFST VSSPFTMHLI
860 870 880 890 900
ACAGSDTCSF GVIPNKSDAV RVAKYLSERL KLDIPVRMHW SACAKGCGQH
910 920 930 940 950
GSGDIGFVGT KTKLNGKAVL AVDVFVGGSP TKEGFKVIQG LPLDKVEEAS
960 970 980 990 1000
YLLLNYYLEN RLEGESFADF AHRVGVDKLK VVLTSLLQEG ECKLLKPESI

SK
Length:1,002
Mass (Da):112,414
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93FE6EE7AB2B78AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06543.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C70319

NCBI Reference Sequences

More...
RefSeqi
NP_213143.1, NC_000918.1
WP_010880081.1, NC_000918.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC06543; AAC06543; aq_206

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1192725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aae:aq_206

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224324.8.peg.174

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06543.1
PIRiC70319
RefSeqiNP_213143.1, NC_000918.1
WP_010880081.1, NC_000918.1

3D structure databases

ProteinModelPortaliO66583
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_206

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06543; AAC06543; aq_206
GeneIDi1192725
KEGGiaae:aq_206
PATRICifig|224324.8.peg.174

Phylogenomic databases

eggNOGiENOG4107QZF Bacteria
COG0155 LUCA
COG1251 LUCA
HOGENOMiHOG000115024
InParanoidiO66583
KOiK00362
OMAiITTFCEE
OrthoDBiPOG091H0PCN

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-156-MONOMER

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR007419 BFD-like_2Fe2S-bd_dom
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR005117 NiRdtase/SiRdtase_haem-b_fer
IPR036136 Nit/Sulf_reduc_fer_like_dom_sf
IPR006067 NO2/SO3_Rdtase_4Fe4S_dom
PfamiView protein in Pfam
PF04324 Fer2_BFD, 1 hit
PF01077 NIR_SIR, 2 hits
PF03460 NIR_SIR_ferr, 2 hits
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
SSF55124 SSF55124, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO66583_AQUAE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O66583
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again