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Protein
Submitted name:

Transcriptional regulator (NtrC family)

Gene

ntrC4

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133ADP; via amide nitrogen and carbonyl oxygenCombined sources1
Binding sitei352ADPCombined sources1
Metal bindingi393ZincCombined sources1
Metal bindingi413ZincCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 167ATPPROSITE-ProRule annotation8
Nucleotide bindingi163 – 167ADPCombined sources5
Nucleotide bindingi222 – 231ATPPROSITE-ProRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Metal-bindingCombined sources, Nucleotide-binding, ZincCombined sources

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-125-MONOMER

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator (NtrC family)Imported
Gene namesi
Name:ntrC4Imported
Ordered Locus Names:aq_164Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei524-aspartylphosphatePROSITE-ProRule annotation1
Disulfide bondi328 ↔ 362Combined sources

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi224324.aq_164

Structurei

3D structure databases

ProteinModelPortaliO66551
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66551

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 117Response regulatoryInterPro annotationAdd BLAST115
Domaini132 – 360Sigma-54 factor interactionInterPro annotationAdd BLAST229

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 278Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C1W Bacteria
COG2204 LUCA
HOGENOMiHOG000058489
InParanoidiO66551
KOiK02481
OMAiAFYHRIN
OrthoDBiPOG091H03UM

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011006 CheY-like_superfamily
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
IPR027417 P-loop_NTPase
IPR001789 Sig_transdc_resp-reg_receiver
IPR002078 Sigma_54_int
IPR025662 Sigma_54_int_dom_ATP-bd_1
PfamiView protein in Pfam
PF02954 HTH_8, 1 hit
PF00072 Response_reg, 1 hit
PF00158 Sigma54_activat, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF52172 SSF52172, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50110 RESPONSE_REGULATORY, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

Sequencei

Sequence statusi: Complete.

O66551-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRVLVVDDE ESITSSLSAI LEEEGYHPDT AKTLREAEKK IKELFFPVIV
60 70 80 90 100
LDVWMPDGDG VNFIDFIKEN SPDSVVIVIT GHGSVDTAVK AIKKGAYEFL
110 120 130 140 150
EKPFSVERFL LTIKHAFEEY SKKAPPQEEI EFVGEHPKIL EIKRLIPKIA
160 170 180 190 200
KSKAPVLITG ESGTGKEIVA RLIHRYSGRK GAFVDLNCAS IPQELAESEL
210 220 230 240 250
FGHEKGAFTG ALTRKKGKLE LADQGTLFLD EVGELDQRVQ AKLLRVLETG
260 270 280 290 300
SFTRLGGNQK IEVDIRVISA TNKNLEEEIK KGNFREDLYY RLSVFQIYLP
310 320 330 340 350
PLRERGKDVI LLAEYFLKKF AKEYKKNCFE LSEETKEYLM KQEWKGNVRE
360 370 380 390 400
LKNLIERAVI LCEGEVIKPE DLGLKEKSWR DLSYLLKIKE LKEAKKEFEK
410 420 430 440
IFIEEKLREY DYDLKRTAEE IGIDLSNLYR KIKSLNIRVK SS
Length:442
Mass (Da):50,742
Last modified:August 1, 1998 - v1
Checksum:iF04A1A4091979B90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06509.1
PIRiD70315
RefSeqiNP_213111.1, NC_000918.1
WP_010880049.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC06509; AAC06509; aq_164
GeneIDi1192694
KEGGiaae:aq_164

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06509.1
PIRiD70315
RefSeqiNP_213111.1, NC_000918.1
WP_010880049.1, NC_000918.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZITNMR-A1-121[»]
2JRLNMR-A/B1-121[»]
3DZDX-ray2.40A/B2-369[»]
3E7LX-ray2.25A/B/C/D380-442[»]
4FTHX-ray3.00A/B374-442[»]
ProteinModelPortaliO66551
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_164

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06509; AAC06509; aq_164
GeneIDi1192694
KEGGiaae:aq_164

Phylogenomic databases

eggNOGiENOG4105C1W Bacteria
COG2204 LUCA
HOGENOMiHOG000058489
InParanoidiO66551
KOiK02481
OMAiAFYHRIN
OrthoDBiPOG091H03UM

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-125-MONOMER

Miscellaneous databases

EvolutionaryTraceiO66551

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011006 CheY-like_superfamily
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
IPR027417 P-loop_NTPase
IPR001789 Sig_transdc_resp-reg_receiver
IPR002078 Sigma_54_int
IPR025662 Sigma_54_int_dom_ATP-bd_1
PfamiView protein in Pfam
PF02954 HTH_8, 1 hit
PF00072 Response_reg, 1 hit
PF00158 Sigma54_activat, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF52172 SSF52172, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50110 RESPONSE_REGULATORY, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO66551_AQUAE
AccessioniPrimary (citable) accession number: O66551
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 18, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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