UniProtKB - O66533 (O66533_AQUAE)
Protein
Submitted name:
Cytochrome c peroxidase
Gene
cpx
Organism
Aquifex aeolicus (strain VF5)
Status
Functioni
Cofactori
hemeUniRule annotationNote: Binds 2 heme groups.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 73 | Heme 1 (covalent)UniRule annotation | 1 | |
Binding sitei | 76 | Heme 1 (covalent)UniRule annotation | 1 | |
Metal bindingi | 77 | Iron (heme 1 axial ligand)UniRule annotation | 1 | |
Metal bindingi | 93 | Iron (heme 1 axial ligand)UniRule annotation | 1 | |
Binding sitei | 218 | Heme 2 (covalent)UniRule annotation | 1 | |
Binding sitei | 221 | Heme 2 (covalent)UniRule annotation | 1 | |
Metal bindingi | 222 | Iron (heme 2 axial ligand)UniRule annotation | 1 | |
Metal bindingi | 305 | Iron (heme 2 axial ligand)UniRule annotation | 1 |
GO - Molecular functioni
- cytochrome-c peroxidase activity Source: GO_Central
- electron transfer activity Source: InterPro
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase, PeroxidaseImported |
Biological process | Electron transportARBA annotation, Transport |
Ligand | HemeUniRule annotationARBA annotation, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | AAEO224324:G1G15-107-MONOMER |
Protein family/group databases
PeroxiBasei | 5036, AaeoDiHCcP |
Names & Taxonomyi
Protein namesi | Submitted name: Cytochrome c peroxidaseImported |
Gene namesi | Name:cpxImported Ordered Locus Names:aq_136Imported |
Organismi | Aquifex aeolicus (strain VF5)Imported |
Taxonomic identifieri | 224324 [NCBI] |
Taxonomic lineagei | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex › |
Proteomesi |
|
Subcellular locationi
- Periplasm ARBA annotation
GO - Cellular componenti
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmARBA annotationPTM / Processingi
Post-translational modificationi
Binds 2 heme groups per subunit.UniRule annotation
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 182 | Cytochrome cInterPro annotationAdd BLAST | 132 | |
Domaini | 204 – 330 | Cytochrome cInterPro annotationAdd BLAST | 127 |
Phylogenomic databases
eggNOGi | COG1858, Bacteria |
HOGENOMi | CLU_034652_1_1_0 |
InParanoidi | O66533 |
OMAi | YKFANVG |
OrthoDBi | 52724at2 |
Family and domain databases
Gene3Di | 1.10.760.10, 2 hits |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR004852, Di-haem_cyt_c_peroxidsae IPR026259, MauG/Cytc_peroxidase |
Pfami | View protein in Pfam PF03150, CCP_MauG, 1 hit PF00034, Cytochrom_C, 1 hit |
PIRSFi | PIRSF000294, Cytochrome-c_peroxidase, 1 hit |
SUPFAMi | SSF46626, SSF46626, 2 hits |
PROSITEi | View protein in PROSITE PS51007, CYTC, 2 hits |
i Sequence
Sequence statusi: Complete.
O66533-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKGLLLMAV FAGFVVAKEK IDDKELLKMA RQYFKPLPKV AENPQNPVTP
60 70 80 90 100
EKVKLGKMLY YDPRLSKSGL ISCNTCHNLA RYGVDNLPTS IGHRWAIGPR
110 120 130 140 150
NAPTVYNAAI HIAQFWDGRA KDVEEQALGP IVNPIEMANT EENAVKTLKS
160 170 180 190 200
IPEYVELFKK AFPNEKDPVK YENIGKAIGA FERTLMTPSR FDEFLKGNTK
210 220 230 240 250
ALTEQEKRGL KTFIEVGCVA CHNGPGVGGN MFAKFGMITE YWKVTYPYVL
260 270 280 290 300
VGKPAIKVDF GRFGVTKKEE DMFVFKVPSL RNIEHTYPYF HDGSVWSLED
310 320 330 340 350
AVRIMAKTQL GKELTDQQVK DIVAFLKALT GKIPKHALEV PELPPSTDKT
PKPEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC06485.1 |
PIRi | B70313 |
RefSeqi | NP_213093.1, NC_000918.1 WP_010880031.1, NC_000918.1 |
Genome annotation databases
EnsemblBacteriai | AAC06485; AAC06485; aq_136 |
KEGGi | aae:aq_136 |
PATRICi | fig|224324.8.peg.116 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC06485.1 |
PIRi | B70313 |
RefSeqi | NP_213093.1, NC_000918.1 WP_010880031.1, NC_000918.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 224324.aq_136 |
Protein family/group databases
PeroxiBasei | 5036, AaeoDiHCcP |
Genome annotation databases
EnsemblBacteriai | AAC06485; AAC06485; aq_136 |
KEGGi | aae:aq_136 |
PATRICi | fig|224324.8.peg.116 |
Phylogenomic databases
eggNOGi | COG1858, Bacteria |
HOGENOMi | CLU_034652_1_1_0 |
InParanoidi | O66533 |
OMAi | YKFANVG |
OrthoDBi | 52724at2 |
Enzyme and pathway databases
BioCyci | AAEO224324:G1G15-107-MONOMER |
Family and domain databases
Gene3Di | 1.10.760.10, 2 hits |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR004852, Di-haem_cyt_c_peroxidsae IPR026259, MauG/Cytc_peroxidase |
Pfami | View protein in Pfam PF03150, CCP_MauG, 1 hit PF00034, Cytochrom_C, 1 hit |
PIRSFi | PIRSF000294, Cytochrome-c_peroxidase, 1 hit |
SUPFAMi | SSF46626, SSF46626, 2 hits |
PROSITEi | View protein in PROSITE PS51007, CYTC, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O66533_AQUAE | |
Accessioni | O66533Primary (citable) accession number: O66533 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 1, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |