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UniProtKB - O66496 (KDSA_AQUAE)
Protein
2-dehydro-3-deoxyphosphooctonate aldolase
Gene
kdsA
Organism
Aquifex aeolicus (strain VF5)
Status
Functioni
Catalytic activityi
- D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-α-D-manno-2-octulosonate-8-phosphate + phosphateEC:2.5.1.55
: 3-deoxy-D-manno-octulosonate biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate. This subpathway is part of the pathway 3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Carbohydrate biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate, the pathway 3-deoxy-D-manno-octulosonate biosynthesis and in Carbohydrate biosynthesis.
Pathwayi: lipopolysaccharide biosynthesis
This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.
GO - Molecular functioni
- 3-deoxy-8-phosphooctulonate synthase activity Source: GO_Central
GO - Biological processi
- keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniRule
- monosaccharide biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | Lipopolysaccharide biosynthesis |
Enzyme and pathway databases
BioCyci | AAEO224324:G1G15-71-MONOMER |
BRENDAi | 2.5.1.55, 396 |
UniPathwayi | UPA00030 UPA00357;UER00474 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-dehydro-3-deoxyphosphooctonate aldolase (EC:2.5.1.55)Alternative name(s): 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase KDO-8-phosphate synthase Short name: KDO 8-P synthase Short name: KDOPS Phospho-2-dehydro-3-deoxyoctonate aldolase |
Gene namesi | Name:kdsA Ordered Locus Names:aq_085 |
Organismi | Aquifex aeolicus (strain VF5) |
Taxonomic identifieri | 224324 [NCBI] |
Taxonomic lineagei | Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Chemistry databases
DrugBanki | DB02992, 1-Deoxy-6-O-Phosphono-1-[(Phosphonomethyl)Amino]-L-Threo-Hexitol DB03248, 2-(Phosphonooxy)Butanoic Acid DB01709, 2-phospho-D-glyceric acid DB03745, Arabinose-5-phosphate DB03937, D-erythrose 4-phosphate DB01819, Phosphoenolpyruvate DB02053, Ribose-5-phosphate DB02433, {[(2,2-Dihydroxy-Ethyl)-(2,3,4,5-Tetrahydroxy-6-Phosphonooxy-Hexyl)-Amino]-Methyl}-Phosphonic Acid |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187099 | 1 – 267 | 2-dehydro-3-deoxyphosphooctonate aldolaseAdd BLAST | 267 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O66496 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O66496 |
Family & Domainsi
Sequence similaritiesi
Belongs to the KdsA family.Curated
Phylogenomic databases
eggNOGi | COG2877, Bacteria |
HOGENOMi | CLU_036666_0_0_0 |
InParanoidi | O66496 |
OMAi | FRGIPTM |
OrthoDBi | 687380at2 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00056, KDO8P_synth, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR006218, DAHP1/KDSA IPR006269, KDO8P_synthase |
PANTHERi | PTHR21057, PTHR21057, 1 hit |
Pfami | View protein in Pfam PF00793, DAHP_synth_1, 1 hit |
TIGRFAMsi | TIGR01362, KDO8P_synth, 1 hit |
i Sequence
Sequence statusi: Complete.
O66496-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKFLVIAGP CAIESEELLL KVGEEIKRLS EKFKEVEFVF KSSFDKANRS
60 70 80 90 100
SIHSFRGHGL EYGVKALRKV KEEFGLKITT DIHESWQAEP VAEVADIIQI
110 120 130 140 150
PAFLCRQTDL LLAAAKTGRA VNVKKGQFLA PWDTKNVVEK LKFGGAKEIY
160 170 180 190 200
LTERGTTFGY NNLVVDFRSL PIMKQWAKVI YDATHSVQLP GGLGDKSGGM
210 220 230 240 250
REFIFPLIRA AVAVGCDGVF METHPEPEKA LSDASTQLPL SQLEGIIEAI
260
LEIREVASKY YETIPVK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC06457.1 |
PIRi | E70308 |
RefSeqi | NP_213056.1, NC_000918.1 WP_010879994.1, NC_000918.1 |
Genome annotation databases
EnsemblBacteriai | AAC06457; AAC06457; aq_085 |
KEGGi | aae:aq_085 |
PATRICi | fig|224324.8.peg.75 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000657 Genomic DNA Translation: AAC06457.1 |
PIRi | E70308 |
RefSeqi | NP_213056.1, NC_000918.1 WP_010879994.1, NC_000918.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FWN | X-ray | 1.94 | A/B | 1-267 | [»] | |
1FWS | X-ray | 1.90 | A/B | 1-267 | [»] | |
1FWT | X-ray | 1.90 | A/B | 1-267 | [»] | |
1FWW | X-ray | 1.85 | A/B | 1-267 | [»] | |
1FX6 | X-ray | 2.06 | A/B | 1-267 | [»] | |
1FXP | X-ray | 1.80 | A/B | 1-267 | [»] | |
1FXQ | X-ray | 1.80 | A/B | 1-267 | [»] | |
1FY6 | X-ray | 1.89 | A/B | 1-267 | [»] | |
1JCX | X-ray | 1.80 | A/B | 1-267 | [»] | |
1JCY | X-ray | 1.90 | A/B | 1-267 | [»] | |
1LRN | X-ray | 2.10 | A/B | 1-267 | [»] | |
1LRO | X-ray | 1.80 | A/B | 1-267 | [»] | |
1LRQ | X-ray | 1.80 | A/B | 1-267 | [»] | |
1PCK | X-ray | 1.80 | A/B | 1-267 | [»] | |
1PCW | X-ray | 1.85 | A/B | 1-267 | [»] | |
1PE1 | X-ray | 1.74 | A/B | 1-267 | [»] | |
1T8X | X-ray | 1.80 | A/B | 1-267 | [»] | |
1T96 | X-ray | 1.85 | A/B | 1-267 | [»] | |
1T99 | X-ray | 1.85 | A/B | 1-267 | [»] | |
1ZHA | X-ray | 1.74 | A/B | 1-267 | [»] | |
1ZJI | X-ray | 2.25 | A/B | 1-267 | [»] | |
2A21 | X-ray | 1.80 | A/B | 1-267 | [»] | |
2A2I | X-ray | 1.95 | A/B | 1-267 | [»] | |
2EF9 | X-ray | 2.00 | A/B | 1-267 | [»] | |
2NWR | X-ray | 1.50 | A/B | 1-267 | [»] | |
2NWS | X-ray | 1.80 | A/B | 1-267 | [»] | |
2NX1 | X-ray | 1.80 | A/B | 1-267 | [»] | |
2NX3 | X-ray | 2.10 | A/B/C/D/E/F/G/H/I/J/K/L | 1-267 | [»] | |
2NXG | X-ray | 1.95 | A/B | 2-264 | [»] | |
2NXH | X-ray | 2.11 | A/B/C/D/E/F/G/H/I/J/K/L | 2-264 | [»] | |
2NXI | X-ray | 2.30 | A/B/C/D/E/F/G/H/I/J/K/L | 2-264 | [»] | |
3E0I | X-ray | 1.70 | A/B | 1-267 | [»] | |
3E12 | X-ray | 1.70 | A/B | 1-267 | [»] | |
SMRi | O66496 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224324.aq_085 |
Chemistry databases
DrugBanki | DB02992, 1-Deoxy-6-O-Phosphono-1-[(Phosphonomethyl)Amino]-L-Threo-Hexitol DB03248, 2-(Phosphonooxy)Butanoic Acid DB01709, 2-phospho-D-glyceric acid DB03745, Arabinose-5-phosphate DB03937, D-erythrose 4-phosphate DB01819, Phosphoenolpyruvate DB02053, Ribose-5-phosphate DB02433, {[(2,2-Dihydroxy-Ethyl)-(2,3,4,5-Tetrahydroxy-6-Phosphonooxy-Hexyl)-Amino]-Methyl}-Phosphonic Acid |
Genome annotation databases
EnsemblBacteriai | AAC06457; AAC06457; aq_085 |
KEGGi | aae:aq_085 |
PATRICi | fig|224324.8.peg.75 |
Phylogenomic databases
eggNOGi | COG2877, Bacteria |
HOGENOMi | CLU_036666_0_0_0 |
InParanoidi | O66496 |
OMAi | FRGIPTM |
OrthoDBi | 687380at2 |
Enzyme and pathway databases
UniPathwayi | UPA00030 UPA00357;UER00474 |
BioCyci | AAEO224324:G1G15-71-MONOMER |
BRENDAi | 2.5.1.55, 396 |
Miscellaneous databases
EvolutionaryTracei | O66496 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00056, KDO8P_synth, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR006218, DAHP1/KDSA IPR006269, KDO8P_synthase |
PANTHERi | PTHR21057, PTHR21057, 1 hit |
Pfami | View protein in Pfam PF00793, DAHP_synth_1, 1 hit |
TIGRFAMsi | TIGR01362, KDO8P_synth, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KDSA_AQUAE | |
Accessioni | O66496Primary (citable) accession number: O66496 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families