UniProtKB - O65902 (ACAP1_ARATH)
Protein
Cyclase-associated protein 1
Gene
CAP1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Actin monomer binding protein that accelerates the exchange of ADP for ATP. Regulates the pool of unpolymerized ATP-actin. Key intermediate between actin-depolymerizing factor (ADF)-mediated disassembly and the profilin-based nucleation and elongation machinery.3 Publications
GO - Molecular functioni
- actin binding Source: GO_Central
- adenylate cyclase binding Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: TAIR
- actin polymerization or depolymerization Source: GO_Central
- cell morphogenesis Source: GO_Central
- establishment or maintenance of cell polarity Source: GO_Central
- unidimensional cell growth Source: TAIR
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclase-associated protein 1Short name: AtCAP1 Alternative name(s): Adenylyl cyclase-associated protein |
Gene namesi | Name:CAP1 Ordered Locus Names:At4g34490 ORF Names:T4L20.70 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G34490 |
TAIRi | locus:2139539 AT4G34490 |
Subcellular locationi
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: TAIR
Pathology & Biotechi
Disruption phenotypei
Stunted growth and reduced pollen germination and growth.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424560 | 1 – 476 | Cyclase-associated protein 1Add BLAST | 476 |
Proteomic databases
PaxDbi | O65902 |
PRIDEi | O65902 |
PTM databases
iPTMneti | O65902 |
Expressioni
Tissue specificityi
Expressed in roots, cotyledons, leaves, stems, flowers, pollen and shoots. Not detected in siliques.2 Publications
Gene expression databases
ExpressionAtlasi | O65902 baseline and differential |
Genevisiblei | O65902 AT |
Interactioni
GO - Molecular functioni
- actin binding Source: GO_Central
- adenylate cyclase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 3702.AT4G34490.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 316 – 453 | C-CAP/cofactor C-likePROSITE-ProRule annotationAdd BLAST | 138 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 214 – 243 | Pro-richAdd BLAST | 30 | |
Compositional biasi | 253 – 256 | Poly-Ser | 4 |
Domaini
The C-terminal domain (318-476) binds to actin.1 Publication
Sequence similaritiesi
Belongs to the CAP family.Curated
Phylogenomic databases
eggNOGi | KOG2675 Eukaryota ENOG410XPXJ LUCA |
HOGENOMi | HOG000206192 |
InParanoidi | O65902 |
KOi | K17261 |
OMAi | ELEGNKW |
OrthoDBi | 1098760at2759 |
PhylomeDBi | O65902 |
Family and domain databases
Gene3Di | 1.25.40.330, 1 hit 2.160.20.70, 1 hit |
InterProi | View protein in InterPro IPR001837 Adenylate_cyclase-assoc_CAP IPR013912 Adenylate_cyclase-assoc_CAP_C IPR013992 Adenylate_cyclase-assoc_CAP_N IPR017901 C-CAP_CF_C-like IPR016098 CAP/MinC_C IPR036223 CAP_C_sf IPR018106 CAP_CS_N IPR036222 CAP_N_sf IPR006599 CARP_motif |
PANTHERi | PTHR10652 PTHR10652, 1 hit |
Pfami | View protein in Pfam PF08603 CAP_C, 1 hit PF01213 CAP_N, 1 hit |
SMARTi | View protein in SMART SM00673 CARP, 2 hits |
SUPFAMi | SSF101278 SSF101278, 1 hit SSF69340 SSF69340, 1 hit |
PROSITEi | View protein in PROSITE PS51329 C_CAP_COFACTOR_C, 1 hit PS01088 CAP_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O65902-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEDLIKRLE AAVTRLEGIS SNGGGVVSLS RGGDFSSAAG IDIASSDPSI
60 70 80 90 100
LAYEDLISQC VGRALTAAEK IGGPVLDVTK IVAEAFASQK ELLVRIKQTQ
110 120 130 140 150
KPDLAGLAGF LKPLNDVTMK ANAMTEGKRS DFFNHLKAAC DSLSALAWIA
160 170 180 190 200
FTGKDCGMSM PIAHVEESWQ MAEFYNNKVL VEYRNKDADH VEWAKALKEL
210 220 230 240 250
YLPGLREYVK SHYPLGPVWN ASGKPASAPA KGPPGAPAPP PAPLFSAESS
260 270 280 290 300
KPSSSSNQKQ GMSAVFQQLS SGAVTSGLRK VTDDMKTKNR ADRSGAVSAV
310 320 330 340 350
EKETRTSKPA FSKTGPPKME LQMGRKWAVE NQIGKKDLVI SECDSKQSVY
360 370 380 390 400
IYGCKDSVLQ IQGKVNNITI DKCTKVGVVF TDVVAAFEIV NCNNVEVQCQ
410 420 430 440 450
GSAPTVSVDN TTGCQLYLNK DSLETAITTA KSSEINVMVP GATPDGDWVE
460 470
HALPQQYNHV FTEGKFETTP VSHSGA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8B7W9 | A0A1P8B7W9_ARATH | Adenylyl cyclase-associated protein | CAP1 ATCAP1, CAP 1, cyclase associated protein 1, At4g34490, T4L20.70 | 543 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014759 mRNA Translation: BAA28621.1 AL023094 Genomic DNA Translation: CAA18828.1 AL161585 Genomic DNA Translation: CAB80166.1 CP002687 Genomic DNA Translation: AEE86385.1 BT029161 mRNA Translation: ABJ17096.1 |
PIRi | T05269 |
RefSeqi | NP_195175.1, NM_119614.6 |
Genome annotation databases
EnsemblPlantsi | AT4G34490.1; AT4G34490.1; AT4G34490 |
GeneIDi | 829600 |
Gramenei | AT4G34490.1; AT4G34490.1; AT4G34490 |
KEGGi | ath:AT4G34490 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014759 mRNA Translation: BAA28621.1 AL023094 Genomic DNA Translation: CAA18828.1 AL161585 Genomic DNA Translation: CAB80166.1 CP002687 Genomic DNA Translation: AEE86385.1 BT029161 mRNA Translation: ABJ17096.1 |
PIRi | T05269 |
RefSeqi | NP_195175.1, NM_119614.6 |
3D structure databases
SMRi | O65902 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT4G34490.1 |
PTM databases
iPTMneti | O65902 |
Proteomic databases
PaxDbi | O65902 |
PRIDEi | O65902 |
Protocols and materials databases
DNASUi | 829600 |
Genome annotation databases
EnsemblPlantsi | AT4G34490.1; AT4G34490.1; AT4G34490 |
GeneIDi | 829600 |
Gramenei | AT4G34490.1; AT4G34490.1; AT4G34490 |
KEGGi | ath:AT4G34490 |
Organism-specific databases
Araporti | AT4G34490 |
TAIRi | locus:2139539 AT4G34490 |
Phylogenomic databases
eggNOGi | KOG2675 Eukaryota ENOG410XPXJ LUCA |
HOGENOMi | HOG000206192 |
InParanoidi | O65902 |
KOi | K17261 |
OMAi | ELEGNKW |
OrthoDBi | 1098760at2759 |
PhylomeDBi | O65902 |
Miscellaneous databases
PROi | PR:O65902 |
Gene expression databases
ExpressionAtlasi | O65902 baseline and differential |
Genevisiblei | O65902 AT |
Family and domain databases
Gene3Di | 1.25.40.330, 1 hit 2.160.20.70, 1 hit |
InterProi | View protein in InterPro IPR001837 Adenylate_cyclase-assoc_CAP IPR013912 Adenylate_cyclase-assoc_CAP_C IPR013992 Adenylate_cyclase-assoc_CAP_N IPR017901 C-CAP_CF_C-like IPR016098 CAP/MinC_C IPR036223 CAP_C_sf IPR018106 CAP_CS_N IPR036222 CAP_N_sf IPR006599 CARP_motif |
PANTHERi | PTHR10652 PTHR10652, 1 hit |
Pfami | View protein in Pfam PF08603 CAP_C, 1 hit PF01213 CAP_N, 1 hit |
SMARTi | View protein in SMART SM00673 CARP, 2 hits |
SUPFAMi | SSF101278 SSF101278, 1 hit SSF69340 SSF69340, 1 hit |
PROSITEi | View protein in PROSITE PS51329 C_CAP_COFACTOR_C, 1 hit PS01088 CAP_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACAP1_ARATH | |
Accessioni | O65902Primary (citable) accession number: O65902 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 11, 2013 |
Last sequence update: | August 1, 1998 | |
Last modified: | September 18, 2019 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names