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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
N/A
Organism
Nicotiana tabacum (Common tobacco)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (LOC107828938), Glucose-6-phosphate 1-dehydrogenase (LOC107822069), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, chloroplastic, Glucose-6-phosphate 1-dehydrogenase (LOC107794892), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (LOC107758909), Glucose-6-phosphate 1-dehydrogenase (LOC107831534), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (G6PDHP2), Glucose-6-phosphate 1-dehydrogenase (LOC107828938), Glucose-6-phosphate 1-dehydrogenase (LOC107786177)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (LOC107777046), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107791333), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107799009), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107789656), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107779182)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
OrganismiNicotiana tabacum (Common tobacco)Imported
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Structurei

3D structure databases

ProteinModelPortaliO65856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 284G6PD_NInterPro annotationAdd BLAST179
Domaini287 – 581G6PD_CInterPro annotationAdd BLAST295

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00036

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

O65856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGQLQLNPC SSSSVATTFH NGAHKFCRNF NILPFKAHSL ESSVASTFHN
60 70 80 90 100
GIYSRIQPRK HFEIMSSNGF HLNAVSLLDG SASKSMPEQV PLTELENAET
110 120 130 140 150
TVSITVIGAS GDLAKKKIFT ALFALFYEDC LPENFIVFGY SRTKMSDEEL
160 170 180 190 200
RNMISKTLTC RIDQRENCEA KMDHFLERCF YHSGQYHSED DFAELDYKLK
210 220 230 240 250
AKEGSRVSNR LFYLSIPPNI FVDVVRCASL KASSTSGWTR VIVEKPFGRD
260 270 280 290 300
LESSSELTRC LKKYLTEEQI FRIDHYLGKE LVENLSVLRF SNLVFEPLWS
310 320 330 340 350
RNYIRNVQFI FSEDSGTEGR GGYFDNYGII RDIMQNHLLQ ILALFAMETP
360 370 380 390 400
VSMDAEDIRN EKVKVLRSMR PLQLEDVVLG QYKGHSKGGK LYPAYTDDPT
410 420 430 440 450
VPNGSVTPTF SAAALFINNA RWDGVPFLMK AGKALHTRRA EIRVQFRHVP
460 470 480 490 500
GNLYKRNFGT DLDKATNELV LRLQPDEAIY LKINNKVPGL GMRLDRSDLN
510 520 530 540 550
LLYKAKYRGE IPDAYERLLL DAIEGERRLF IRSDELDAAW ALFTPLLKEL
560 570 580
EEKKIAPELY PYGSRGPVGA HYLAAKHNVR WGDLSGDD
Length:588
Mass (Da):66,801
Last modified:August 1, 1998 - v1
Checksum:i68106BC1E1CF5F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001772 mRNA Translation: CAA04994.1
PIRiT03740
RefSeqiNP_001312522.1, NM_001325593.1
UniGeneiNta.3687

Genome annotation databases

GeneIDi107794892
KEGGinta:107794892

Similar proteinsi

Entry informationi

Entry nameiO65856_TOBAC
AccessioniPrimary (citable) accession number: O65856
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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