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Protein

Heat shock 70 kDa protein 3

Gene

HSP70-3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protease binding Source: UniProtKB

GO - Biological processi

  • response to cadmium ion Source: TAIR
  • response to heat Source: UniProtKB
  • response to karrikin Source: TAIR
  • response to virus Source: UniProtKB

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-72163 mRNA Splicing - Major Pathway
R-ATH-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 3
Alternative name(s):
Heat shock cognate 70 kDa protein 3
Heat shock cognate protein 70-3
Short name:
AtHsc70-3
Heat shock protein 70-3
Short name:
AtHsp70-3
Gene namesi
Name:HSP70-3
Synonyms:HSC70-3, HSC70-G7
Ordered Locus Names:At3g09440
ORF Names:F11F8, F3L24.33
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G09440
TAIRilocus:2074984 AT3G09440

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783461 – 649Heat shock 70 kDa protein 3Add BLAST649

Proteomic databases

PaxDbiO65719
PRIDEiO65719

2D gel databases

SWISS-2DPAGEiO65719
World-2DPAGEi0003:O65719

PTM databases

iPTMnetiO65719
SwissPalmiO65719

Expressioni

Developmental stagei

Down-regulated during seed maturation. Up-regulated during germination.1 Publication

Inductioni

By heat shock and by cold. Up-regulated by virus infection.2 Publications

Gene expression databases

ExpressionAtlasiO65719 differential
GenevisibleiO65719 AT

Interactioni

Subunit structurei

Interacts with GDP-mannose 3,5-epimerase and SGT1B (via SGS domain). Binds to the deubiquitinating enzyme AMSH3. Interacts with WPP1.4 Publications

GO - Molecular functioni

  • protease binding Source: UniProtKB

Protein-protein interaction databases

BioGridi5436, 17 interactors
IntActiO65719, 3 interactors
STRINGi3702.AT3G09440.1

Structurei

3D structure databases

ProteinModelPortaliO65719
SMRiO65719
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
HOGENOMiHOG000228135
InParanoidiO65719
KOiK03283
OMAiMILIKMR
OrthoDBiEOG093604KP
PhylomeDBiO65719

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

O65719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKGEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS
60 70 80 90 100
ERLIGDAAKN QVAMNPINTV FDAKRLIGRR FTDSSVQSDI KLWPFTLKSG
110 120 130 140 150
PAEKPMIVVN YKGEDKEFSA EEISSMILIK MREIAEAYLG TTIKNAVVTV
160 170 180 190 200
PAYFNDSQRQ ATKDAGVIAG LNVMRIINEP TAAAIAYGLD KKATSVGEKN
210 220 230 240 250
VLIFDLGGGT FDVSLLTIEE GIFEVKATAG DTHLGGEDFD NRMVNHFVQE
260 270 280 290 300
FKRKNKKDIS GNPRALRRLR TACERAKRTL SSTAQTTIEI DSLFDGIDFY
310 320 330 340 350
APITRARFEE LNIDLFRKCM EPVEKCLRDA KMDKNSIDDV VLVGGSTRIP
360 370 380 390 400
KVQQLLVDFF NGKELCKSIN PDEAVAYGAA VQAAILSGEG NEKVQDLLLL
410 420 430 440 450
DVTPLSLGLE TAGGVMTVLI QRNTTIPTKK EQVFSTYSDN QPGVLIQVYE
460 470 480 490 500
GERARTKDNN LLGKFELSGI PPAPRGVPQI TVCFDIDANG ILNVSAEDKT
510 520 530 540 550
TGQKNKITIT NDKGRLSKDE IEKMVQEAEK YKSEDEEHKK KVDAKNALEN
560 570 580 590 600
YAYNMRNTIR DEKIGEKLAG DDKKKIEDSI EAAIEWLEAN QLAECDEFED
610 620 630 640
KMKELESICN PIIAKMYQGG EAGGPAAGGM DEDVPPSAGG AGPKIEEVD
Length:649
Mass (Da):71,148
Last modified:August 1, 1998 - v1
Checksum:i453268ED6E60E152
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113 – 117GEDKE → EKIKS in CAA23383 (PubMed:8580968).Curated5
Sequence conflicti556R → T in CAA70111 (Ref. 7) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17053 mRNA Translation: CAA76606.1
AC011436 Genomic DNA Translation: AAF14038.1
AC016661 Genomic DNA Translation: AAF23276.1
CP002686 Genomic DNA Translation: AEE74767.1
CP002686 Genomic DNA Translation: AEE74768.1
CP002686 Genomic DNA Translation: ANM64320.1
CP002686 Genomic DNA Translation: ANM64321.1
AY050896 mRNA Translation: AAK92833.1
AY096676 mRNA Translation: AAM20310.1
AY102116 mRNA Translation: AAM26685.1
BT001066 mRNA Translation: AAN46823.1
F20026 mRNA Translation: CAA23383.1
AK222065 mRNA Translation: BAD94875.1
Y08903 mRNA Translation: CAA70111.1
RefSeqiNP_001189847.1, NM_001202918.1
NP_001319509.1, NM_001337819.1
NP_001319510.1, NM_001337820.1
NP_187555.1, NM_111778.4
UniGeneiAt.22293

Genome annotation databases

EnsemblPlantsiAT3G09440.1; AT3G09440.1; AT3G09440
AT3G09440.2; AT3G09440.2; AT3G09440
AT3G09440.3; AT3G09440.3; AT3G09440
AT3G09440.4; AT3G09440.4; AT3G09440
GeneIDi820102
GrameneiAT3G09440.1; AT3G09440.1; AT3G09440
AT3G09440.2; AT3G09440.2; AT3G09440
AT3G09440.3; AT3G09440.3; AT3G09440
AT3G09440.4; AT3G09440.4; AT3G09440
KEGGiath:AT3G09440

Similar proteinsi

Entry informationi

Entry nameiHSP7C_ARATH
AccessioniPrimary (citable) accession number: O65719
Secondary accession number(s): Q42345, Q56WH5, Q96267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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