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UniProtKB - O65719 (HSP7C_ARATH)
Protein
Heat shock 70 kDa protein 3
Gene
HSP70-3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions.
CuratedGO - Molecular functioni
- ATP binding Source: GO_Central
- ATP hydrolysis activity Source: GO_Central
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- mRNA binding Source: TAIR
- protease binding Source: UniProtKB
- protein folding chaperone Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- protein refolding Source: GO_Central
- response to heat Source: UniProtKB
- response to virus Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 70 kDa protein 32 PublicationsShort name: AtHsp70-32 Publications Short name: Heat shock protein 70-32 Publications Alternative name(s): Heat shock cognate 70 kDa protein 31 Publication Short name: AtHsc70-31 Publication Short name: Heat shock cognate protein 70-31 Publication |
Gene namesi | Name:HSP70-32 Publications Synonyms:HSC70-31 Publication, HSC70-G7 Ordered Locus Names:At3g09440Imported ORF Names:F11F8Imported, F3L24.33Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G09440 |
TAIRi | locus:2074984, AT3G09440 |
Subcellular locationi
Nucleus
- Nucleus matrix 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cell Wall
- plant-type cell wall Source: TAIR
Chloroplast
- chloroplast Source: TAIR
Cytosol
- cytosol Source: TAIR
- cytosolic ribosome Source: TAIR
Extracellular region or secreted
- apoplast Source: TAIR
Golgi apparatus
- Golgi apparatus Source: TAIR
Nucleus
- nuclear matrix Source: UniProtKB
Plasma Membrane
- plasma membrane Source: TAIR
Vacuole
- plant-type vacuole Source: TAIR
- vacuole Source: TAIR
Other locations
- cytoplasm Source: GO_Central
- plasmodesma Source: TAIR
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078346 | 1 – 649 | Heat shock 70 kDa protein 3Add BLAST | 649 |
Proteomic databases
PaxDbi | O65719 |
PRIDEi | O65719 |
ProteomicsDBi | 230157 |
2D gel databases
SWISS-2DPAGEi | O65719 |
World-2DPAGEi | 0003:O65719 |
PTM databases
iPTMneti | O65719 |
MetOSitei | O65719 |
SwissPalmi | O65719 |
Expressioni
Developmental stagei
Down-regulated during seed maturation. Up-regulated during germination.1 Publication
Inductioni
By heat shock and by cold. Up-regulated by virus infection.2 Publications
Gene expression databases
ExpressionAtlasi | O65719, baseline and differential |
Genevisiblei | O65719, AT |
Interactioni
Subunit structurei
Interacts with GDP-mannose 3,5-epimerase and SGT1B (via SGS domain). Binds to the deubiquitinating enzyme AMSH3.
Interacts with WPP1.
Interacts with DEK3 (PubMed:25387881).
5 PublicationsGO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protease binding Source: UniProtKB
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 5436, 29 interactors |
IntActi | O65719, 4 interactors |
STRINGi | 3702.AT3G09440.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 619 – 649 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the heat shock protein 70 (TC 1.A.33) family. DnaK subfamily. [View classification]Curated
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
HOGENOMi | CLU_005965_5_1_1 |
InParanoidi | O65719 |
OMAi | NCGQHAG |
OrthoDBi | 288077at2759 |
PhylomeDBi | O65719 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O65719-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGKGEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS
60 70 80 90 100
ERLIGDAAKN QVAMNPINTV FDAKRLIGRR FTDSSVQSDI KLWPFTLKSG
110 120 130 140 150
PAEKPMIVVN YKGEDKEFSA EEISSMILIK MREIAEAYLG TTIKNAVVTV
160 170 180 190 200
PAYFNDSQRQ ATKDAGVIAG LNVMRIINEP TAAAIAYGLD KKATSVGEKN
210 220 230 240 250
VLIFDLGGGT FDVSLLTIEE GIFEVKATAG DTHLGGEDFD NRMVNHFVQE
260 270 280 290 300
FKRKNKKDIS GNPRALRRLR TACERAKRTL SSTAQTTIEI DSLFDGIDFY
310 320 330 340 350
APITRARFEE LNIDLFRKCM EPVEKCLRDA KMDKNSIDDV VLVGGSTRIP
360 370 380 390 400
KVQQLLVDFF NGKELCKSIN PDEAVAYGAA VQAAILSGEG NEKVQDLLLL
410 420 430 440 450
DVTPLSLGLE TAGGVMTVLI QRNTTIPTKK EQVFSTYSDN QPGVLIQVYE
460 470 480 490 500
GERARTKDNN LLGKFELSGI PPAPRGVPQI TVCFDIDANG ILNVSAEDKT
510 520 530 540 550
TGQKNKITIT NDKGRLSKDE IEKMVQEAEK YKSEDEEHKK KVDAKNALEN
560 570 580 590 600
YAYNMRNTIR DEKIGEKLAG DDKKKIEDSI EAAIEWLEAN QLAECDEFED
610 620 630 640
KMKELESICN PIIAKMYQGG EAGGPAAGGM DEDVPPSAGG AGPKIEEVD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 113 – 117 | GEDKE → EKIKS in CAA23383 (PubMed:8580968).Curated | 5 | |
Sequence conflicti | 556 | R → T in CAA70111 (Ref. 7) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y17053 mRNA Translation: CAA76606.1 AC011436 Genomic DNA Translation: AAF14038.1 AC016661 Genomic DNA Translation: AAF23276.1 CP002686 Genomic DNA Translation: AEE74767.1 CP002686 Genomic DNA Translation: AEE74768.1 CP002686 Genomic DNA Translation: ANM64320.1 CP002686 Genomic DNA Translation: ANM64321.1 AY050896 mRNA Translation: AAK92833.1 AY096676 mRNA Translation: AAM20310.1 AY102116 mRNA Translation: AAM26685.1 BT001066 mRNA Translation: AAN46823.1 F20026 mRNA Translation: CAA23383.1 AK222065 mRNA Translation: BAD94875.1 Y08903 mRNA Translation: CAA70111.1 |
RefSeqi | NP_001189847.1, NM_001202918.1 NP_001319509.1, NM_001337819.1 NP_001319510.1, NM_001337820.1 NP_187555.1, NM_111778.4 |
Genome annotation databases
EnsemblPlantsi | AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440 |
GeneIDi | 820102 |
Gramenei | AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440 |
KEGGi | ath:AT3G09440 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y17053 mRNA Translation: CAA76606.1 AC011436 Genomic DNA Translation: AAF14038.1 AC016661 Genomic DNA Translation: AAF23276.1 CP002686 Genomic DNA Translation: AEE74767.1 CP002686 Genomic DNA Translation: AEE74768.1 CP002686 Genomic DNA Translation: ANM64320.1 CP002686 Genomic DNA Translation: ANM64321.1 AY050896 mRNA Translation: AAK92833.1 AY096676 mRNA Translation: AAM20310.1 AY102116 mRNA Translation: AAM26685.1 BT001066 mRNA Translation: AAN46823.1 F20026 mRNA Translation: CAA23383.1 AK222065 mRNA Translation: BAD94875.1 Y08903 mRNA Translation: CAA70111.1 |
RefSeqi | NP_001189847.1, NM_001202918.1 NP_001319509.1, NM_001337819.1 NP_001319510.1, NM_001337820.1 NP_187555.1, NM_111778.4 |
3D structure databases
AlphaFoldDBi | O65719 |
SMRi | O65719 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 5436, 29 interactors |
IntActi | O65719, 4 interactors |
STRINGi | 3702.AT3G09440.1 |
PTM databases
iPTMneti | O65719 |
MetOSitei | O65719 |
SwissPalmi | O65719 |
2D gel databases
SWISS-2DPAGEi | O65719 |
World-2DPAGEi | 0003:O65719 |
Proteomic databases
PaxDbi | O65719 |
PRIDEi | O65719 |
ProteomicsDBi | 230157 |
Genome annotation databases
EnsemblPlantsi | AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440 |
GeneIDi | 820102 |
Gramenei | AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440 |
KEGGi | ath:AT3G09440 |
Organism-specific databases
Araporti | AT3G09440 |
TAIRi | locus:2074984, AT3G09440 |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
HOGENOMi | CLU_005965_5_1_1 |
InParanoidi | O65719 |
OMAi | NCGQHAG |
OrthoDBi | 288077at2759 |
PhylomeDBi | O65719 |
Miscellaneous databases
PROi | PR:O65719 |
Gene expression databases
ExpressionAtlasi | O65719, baseline and differential |
Genevisiblei | O65719, AT |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 1 hit SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HSP7C_ARATH | |
Accessioni | O65719Primary (citable) accession number: O65719 Secondary accession number(s): Q42345, Q56WH5, Q96267 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families