HSP70-3

Functionⁱ

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protease binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20543027

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

response to cadmium ion
Source: TAIR
Inferred from expression patternⁱ
- 16502469
response to heat
Source: UniProtKB
Inferred from expression patternⁱ
- 15805473
response to karrikin
Source: TAIR
Inferred from expression patternⁱ
- 20351290
response to virus
Source: UniProtKB
Inferred from expression patternⁱ
- 15805473

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Stress response
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-ATH-3371453 Regulation of HSF1-mediated heat shock response R-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-ATH-3371571 HSF1-dependent transactivation R-ATH-6798695 Neutrophil degranulation R-ATH-72163 mRNA Splicing - Major Pathway R-ATH-8876725 Protein methylation

Reactomeⁱ

R-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-72163 mRNA Splicing - Major Pathway
R-ATH-8876725 Protein methylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock 70 kDa protein 3 Alternative name(s): Heat shock cognate 70 kDa protein 3 Heat shock cognate protein 70-3 Short name: AtHsc70-3 Heat shock protein 70-3 Short name: AtHsp70-3
Gene namesⁱ	Name:HSP70-3 Synonyms:HSC70-3, HSC70-G7 Ordered Locus Names:At3g09440 ORF Names:F11F8, F3L24.33
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT3G09440
TAIRⁱ	locus:2074984 AT3G09440

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000078346	1 – 649	Heat shock 70 kDa protein 3Add BLAST		649

Proteomic databases

PaxDbⁱ	O65719
PRIDEⁱ	O65719

2D gel databases

SWISS-2DPAGEⁱ	O65719
The World-2DPAGE database More...World-2DPAGEⁱ	0003:O65719

PTM databases

iPTMnetⁱ	O65719
SwissPalmⁱ	O65719

Expressionⁱ

Developmental stageⁱ

Down-regulated during seed maturation. Up-regulated during germination.1 Publication

Inductionⁱ

By heat shock and by cold. Up-regulated by virus infection.2 Publications

Gene expression databases

ExpressionAtlasⁱ	O65719 differential
Genevisibleⁱ	O65719 AT

Interactionⁱ

Subunit structureⁱ

Interacts with GDP-mannose 3,5-epimerase and SGT1B (via SGS domain). Binds to the deubiquitinating enzyme AMSH3. Interacts with WPP1.4 Publications

GO - Molecular functionⁱ

protease binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20543027

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	5436, 17 interactors
IntActⁱ	O65719, 3 interactors
STRINGⁱ	3702.AT3G09440.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O65719
SMRⁱ	O65719
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heat shock protein 70 (TC 1.A.33) family. DnaK subfamily. [View classification]Curated

Phylogenomic databases

eggNOGⁱ	KOG0101 Eukaryota COG0443 LUCA
HOGENOMⁱ	HOG000228135
InParanoidⁱ	O65719
KEGG Orthology (KO) More...KOⁱ	K03283
OMAⁱ	MILIKMR
Database of Orthologous Groups More...OrthoDBⁱ	EOG093604KP
PhylomeDBⁱ	O65719

Family and domain databases

Gene3Dⁱ	1.20.1270.10, 1 hit 2.60.34.10, 1 hit
InterProⁱ	View protein in InterPro IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam
PANTHERⁱ	PTHR19375 PTHR19375, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012 HSP70, 1 hit
PRINTSⁱ	PR00301 HEATSHOCK70
SUPFAMⁱ	SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit
PROSITEⁱ	View protein in PROSITE PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O65719-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGKGEGPAI GIDLGTTYSC VGVWQHDRVE IIANDQGNRT TPSYVAFTDS 
        60         70         80         90        100
ERLIGDAAKN QVAMNPINTV FDAKRLIGRR FTDSSVQSDI KLWPFTLKSG 
       110        120        130        140        150
PAEKPMIVVN YKGEDKEFSA EEISSMILIK MREIAEAYLG TTIKNAVVTV 
       160        170        180        190        200
PAYFNDSQRQ ATKDAGVIAG LNVMRIINEP TAAAIAYGLD KKATSVGEKN 
       210        220        230        240        250
VLIFDLGGGT FDVSLLTIEE GIFEVKATAG DTHLGGEDFD NRMVNHFVQE 
       260        270        280        290        300
FKRKNKKDIS GNPRALRRLR TACERAKRTL SSTAQTTIEI DSLFDGIDFY 
       310        320        330        340        350
APITRARFEE LNIDLFRKCM EPVEKCLRDA KMDKNSIDDV VLVGGSTRIP 
       360        370        380        390        400
KVQQLLVDFF NGKELCKSIN PDEAVAYGAA VQAAILSGEG NEKVQDLLLL 
       410        420        430        440        450
DVTPLSLGLE TAGGVMTVLI QRNTTIPTKK EQVFSTYSDN QPGVLIQVYE 
       460        470        480        490        500
GERARTKDNN LLGKFELSGI PPAPRGVPQI TVCFDIDANG ILNVSAEDKT 
       510        520        530        540        550
TGQKNKITIT NDKGRLSKDE IEKMVQEAEK YKSEDEEHKK KVDAKNALEN 
       560        570        580        590        600
YAYNMRNTIR DEKIGEKLAG DDKKKIEDSI EAAIEWLEAN QLAECDEFED 
       610        620        630        640 
KMKELESICN PIIAKMYQGG EAGGPAAGGM DEDVPPSAGG AGPKIEEVD

Length:649

Mass (Da):71,148

Last modified:August 1, 1998 - v1

Checksum:ⁱ453268ED6E60E152

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	113 – 117	GEDKE → EKIKS in CAA23383 (PubMed:8580968).Curated		5
Sequence conflictⁱ	556	R → T in CAA70111 (Ref. 7) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y17053 mRNA Translation: CAA76606.1 AC011436 Genomic DNA Translation: AAF14038.1 AC016661 Genomic DNA Translation: AAF23276.1 CP002686 Genomic DNA Translation: AEE74767.1 CP002686 Genomic DNA Translation: AEE74768.1 CP002686 Genomic DNA Translation: ANM64320.1 CP002686 Genomic DNA Translation: ANM64321.1 AY050896 mRNA Translation: AAK92833.1 AY096676 mRNA Translation: AAM20310.1 AY102116 mRNA Translation: AAM26685.1 BT001066 mRNA Translation: AAN46823.1 F20026 mRNA Translation: CAA23383.1 AK222065 mRNA Translation: BAD94875.1 Y08903 mRNA Translation: CAA70111.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001189847.1, NM_001202918.1 NP_001319509.1, NM_001337819.1 NP_001319510.1, NM_001337820.1 NP_187555.1, NM_111778.4
UniGeneⁱ	At.22293

Genome annotation databases

EnsemblPlantsⁱ	AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440
GeneIDⁱ	820102
Grameneⁱ	AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440
KEGGⁱ	ath:AT3G09440

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
O65719	Probable mediator of RNA polymerase II transcription subunit 37e		ARATH		651
Uncharacterized protein		EUCGR		742
Uncharacterized protein		AMBTC		657
Uncharacterized protein		AQUCA		656
UPI0005108915		Chinese white pear		656
+751

Protein	Similar proteins		Species	Score	Length
O65719	Probable mediator of RNA polymerase II transcription subunit 37e		ARATH		651
Uncharacterized protein		EUCGR		742
Uncharacterized protein		AMBTC		657
UPI0005108915		Chinese white pear		656
Uncharacterized protein		AQUCA		656
+1084

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y17053 mRNA Translation: CAA76606.1 AC011436 Genomic DNA Translation: AAF14038.1 AC016661 Genomic DNA Translation: AAF23276.1 CP002686 Genomic DNA Translation: AEE74767.1 CP002686 Genomic DNA Translation: AEE74768.1 CP002686 Genomic DNA Translation: ANM64320.1 CP002686 Genomic DNA Translation: ANM64321.1 AY050896 mRNA Translation: AAK92833.1 AY096676 mRNA Translation: AAM20310.1 AY102116 mRNA Translation: AAM26685.1 BT001066 mRNA Translation: AAN46823.1 F20026 mRNA Translation: CAA23383.1 AK222065 mRNA Translation: BAD94875.1 Y08903 mRNA Translation: CAA70111.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001189847.1, NM_001202918.1 NP_001319509.1, NM_001337819.1 NP_001319510.1, NM_001337820.1 NP_187555.1, NM_111778.4
UniGeneⁱ	At.22293

3D structure databases

ProteinModelPortalⁱ	O65719
SMRⁱ	O65719
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	5436, 17 interactors
IntActⁱ	O65719, 3 interactors
STRINGⁱ	3702.AT3G09440.1

PTM databases

iPTMnetⁱ	O65719
SwissPalmⁱ	O65719

2D gel databases

SWISS-2DPAGEⁱ	O65719
The World-2DPAGE database More...World-2DPAGEⁱ	0003:O65719

Proteomic databases

PaxDbⁱ	O65719
PRIDEⁱ	O65719

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440
GeneIDⁱ	820102
Grameneⁱ	AT3G09440.1; AT3G09440.1; AT3G09440 AT3G09440.2; AT3G09440.2; AT3G09440 AT3G09440.3; AT3G09440.3; AT3G09440 AT3G09440.4; AT3G09440.4; AT3G09440
KEGGⁱ	ath:AT3G09440

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT3G09440
TAIRⁱ	locus:2074984 AT3G09440

Phylogenomic databases

eggNOGⁱ	KOG0101 Eukaryota COG0443 LUCA
HOGENOMⁱ	HOG000228135
InParanoidⁱ	O65719
KEGG Orthology (KO) More...KOⁱ	K03283
OMAⁱ	MILIKMR
Database of Orthologous Groups More...OrthoDBⁱ	EOG093604KP
PhylomeDBⁱ	O65719

Enzyme and pathway databases

Reactomeⁱ	R-ATH-3371453 Regulation of HSF1-mediated heat shock response R-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-ATH-3371571 HSF1-dependent transactivation R-ATH-6798695 Neutrophil degranulation R-ATH-72163 mRNA Splicing - Major Pathway R-ATH-8876725 Protein methylation

Reactomeⁱ

R-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-72163 mRNA Splicing - Major Pathway
R-ATH-8876725 Protein methylation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O65719

PROⁱ

PR:O65719

Gene expression databases

ExpressionAtlasⁱ	O65719 differential
Genevisibleⁱ	O65719 AT

Family and domain databases

Gene3Dⁱ	1.20.1270.10, 1 hit 2.60.34.10, 1 hit
InterProⁱ	View protein in InterPro IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam
PANTHERⁱ	PTHR19375 PTHR19375, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012 HSP70, 1 hit
PRINTSⁱ	PR00301 HEATSHOCK70
SUPFAMⁱ	SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 1 hit
PROSITEⁱ	View protein in PROSITE PS00297 HSP70_1, 1 hit PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HSP7C_ARATH
Accessionⁱ	O65719Primary (citable) accession number: O65719 Secondary accession number(s): Q42345, Q56WH5, Q96267
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	August 1, 1998
	Last modified:	May 23, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

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UniProtKB - O65719 (HSP7C_ARATH)

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Heat shock 70 kDa protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cell Wall

Chloroplast

Cytosol

Extracellular region or secreted

Golgi apparatus

Nucleus

Plasma Membrane

Vacuole

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ