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Entry version 114 (16 Oct 2019)
Sequence version 4 (01 Jun 2002)
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Protein

Protoheme IX farnesyltransferase, mitochondrial

Gene

COX10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts protoheme IX and farnesyl diphosphate to heme O.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protoheme IX farnesyltransferase, mitochondrial (EC:2.5.1.141By similarity)
Alternative name(s):
Cytochrome c oxidase assembly protein COX10
Heme O synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX10
Ordered Locus Names:At2g44520
ORF Names:F16B22_1, F4I1.50
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G44520

The Arabidopsis Information Resource

More...
TAIRi
locus:2042316 AT2G44520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei131 – 153HelicalSequence analysisAdd BLAST23
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Transmembranei298 – 317HelicalSequence analysisAdd BLAST20
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041256334 – 431Protoheme IX farnesyltransferase, mitochondrialAdd BLAST398

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O64886

PRoteomics IDEntifications database

More...
PRIDEi
O64886

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O64886 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O64886 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G44520.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1380 Eukaryota
COG0109 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006000

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O64886

KEGG Orthology (KO)

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KOi
K02257

Identification of Orthologs from Complete Genome Data

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OMAi
VTNYWFA

Database of Orthologous Groups

More...
OrthoDBi
1260807at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O64886

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13957 PT_UbiA_Cox10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00154 CyoE_CtaB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR016315 Protohaem_IX_farnesylTrfase_mt
IPR000537 UbiA_prenyltransferase

The PANTHER Classification System

More...
PANTHERi
PTHR43448 PTHR43448, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01040 UbiA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001773 COX10, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01473 cyoE_ctaB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O64886-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRRSVVYRF SSRISVSSSL PNPRLIPWSR ELCAVNSFSQ PPVSTESTAK
60 70 80 90 100
LGITGVRSDA NRVFATATAA ATATATTGEI SSRVAALAGL GHHYARCYWE
110 120 130 140 150
LSKAKLSMLV VATSGTGYIL GTGNAAISFP GLCYTCAGTM MIAASANSLN
160 170 180 190 200
QIFEISNDSK MKRTMLRPLP SGRISVPHAV AWATIAGASG ACLLASKTNM
210 220 230 240 250
LAAGLASANL VLYAFVYTPL KQLHPINTWV GAVVGAIPPL LGWAAASGQI
260 270 280 290 300
SYNSMILPAA LYFWQIPHFM ALAHLCRNDY AAGGYKMLSL FDPSGKRIAA
310 320 330 340 350
VALRNCFYMI PLGFIAYDWG LTSSWFCLES TLLTLAIAAT AFSFYRDRTM
360 370 380 390 400
HKARKMFHAS LLFLPVFMSG LLLHRVSNDN QQQLVEEAGL TNSVSGEVKT
410 420 430
QRRKKRVAQP PVAYASAAPF PFLPAPSFYS P
Length:431
Mass (Da):46,475
Last modified:June 1, 2002 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECBEB38647DA9A30
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC003672 Genomic DNA Translation: AAC27454.3
AC004521 Genomic DNA Translation: AAM14960.1
CP002685 Genomic DNA Translation: AEC10432.1
AY045952 mRNA Translation: AAK76626.1
AY114016 mRNA Translation: AAM45064.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E84879
T01579

NCBI Reference Sequences

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RefSeqi
NP_566019.1, NM_130015.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G44520.1; AT2G44520.1; AT2G44520

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819059

Gramene; a comparative resource for plants

More...
Gramenei
AT2G44520.1; AT2G44520.1; AT2G44520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G44520

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003672 Genomic DNA Translation: AAC27454.3
AC004521 Genomic DNA Translation: AAM14960.1
CP002685 Genomic DNA Translation: AEC10432.1
AY045952 mRNA Translation: AAK76626.1
AY114016 mRNA Translation: AAM45064.1
PIRiE84879
T01579
RefSeqiNP_566019.1, NM_130015.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT2G44520.1

Proteomic databases

PaxDbiO64886
PRIDEiO64886

Genome annotation databases

EnsemblPlantsiAT2G44520.1; AT2G44520.1; AT2G44520
GeneIDi819059
GrameneiAT2G44520.1; AT2G44520.1; AT2G44520
KEGGiath:AT2G44520

Organism-specific databases

AraportiAT2G44520
TAIRilocus:2042316 AT2G44520

Phylogenomic databases

eggNOGiKOG1380 Eukaryota
COG0109 LUCA
HOGENOMiHOG000006000
InParanoidiO64886
KOiK02257
OMAiVTNYWFA
OrthoDBi1260807at2759
PhylomeDBiO64886

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O64886

Gene expression databases

ExpressionAtlasiO64886 baseline and differential
GenevisibleiO64886 AT

Family and domain databases

CDDicd13957 PT_UbiA_Cox10, 1 hit
HAMAPiMF_00154 CyoE_CtaB, 1 hit
InterProiView protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR016315 Protohaem_IX_farnesylTrfase_mt
IPR000537 UbiA_prenyltransferase
PANTHERiPTHR43448 PTHR43448, 1 hit
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
PIRSFiPIRSF001773 COX10, 1 hit
TIGRFAMsiTIGR01473 cyoE_ctaB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX10_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O64886
Secondary accession number(s): Q94AL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2002
Last modified: October 16, 2019
This is version 114 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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